Abstract: The present invention provides methods for treating a PCSK9-mediated disease or a PCSK9-mediated condition. Specifically, the invention relates to methods comprising the administration of a proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody or antigen binding protein, in the absence of a statin, to a subject in need thereof.

Abstract: The terminal portion of a prefabricated skirt is connected to a casing of a thruster body in the vicinity of an end wall thereof using a method including positioning the terminal portion of the skirt with circumferential clearance around the casing of the thruster body in the vicinity of the end wall; keeping the skirt in position relative to the casing of the thruster body; closing both ends of an annular space between the terminal portion of the skirt and the casing of the thruster body; injecting elastomer into the annular space; and curing the elastomer.

Abstract: The present invention provides methods for treating a PCSK9-mediated disease or a PCSK9-mediated condition. Specifically, the invention relates to methods comprising the administration of a proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody or antigen binding protein, in the absence of a statin, to a subject in need thereof.

Abstract: The present invention provides methods for treating a PCSK9-mediated disease or a PCSK9-mediated condition. Specifically, the invention relates to methods comprising the administration of a proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody or antigen binding protein, in the absence of a statin, to a subject in need thereof.

Abstract: The terminal portion of a prefabricated skirt is connected to a casing of a thruster body in the vicinity of an end wall thereof using a method including positioning the terminal portion of the skirt with circumferential clearance around the casing of the thruster body in the vicinity of the end wall; keeping the skirt in position relative to the casing of the thruster body; closing both ends of an annular space between the terminal portion of the skirt and the casing of the thruster body; injecting elastomer into the annular space; and curing the elastomer.

Abstract: A crosslinkable elastomer composition includes a mixture (a) of an elastomer composition based on an ethylene-propylene-diene terpolymer elastomer and (b) between 2 and 14 wt. %, in relation to the total weight of the composition, of an amphiphilic statistical or block copolymer of a saturated or unsaturated hydrocarbonated C2-C4 polymer functionalized by a polar functional group including a maleic anhydride group.

Abstract: The present invention provides methods for treating a PCSK9-mediated disease or a PCSK9-mediated condition. Specifically, the invention relates to methods comprising the administration of a proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody or antigen binding protein, in the absence of a statin, to a subject in need thereof.

Abstract: A plurality of substrates (10) are disposed in alternation and in contact with layers (12) which constitute sources of metal-based composition, each layer comprising a majority phase formed by the metal-based composition and a minority phase suitable for forming a structure for retaining and draining the metal-based composition when it is in the molten state. The batch is heated to a temperature greater than the melting temperature of the metal-based composition such that the metal-based composition in the molten state can migrate from each source through the adjacent surface of the, or each, substrate adjacent to the source towards the inside of the substrate. The invention seeks in particular to incorporate a silicon-based composition in a thermostructural composite material, in particular a carbon-carbon composite material for siliciding purposes.

Abstract: A reaction gas containing methyltrichlorosilane (MTS) and hydrogen is injected into the infiltration chamber (30) in which the substrate is placed and where predetermined infiltration temperature and pressure conditions obtain. The gas entering the infiltration chamber is preheated (by plates 46) so as to bring it up to temperature before coming into contact with the substrate. The residual gas containing the remainder of the reaction gas together with gaseous reaction products is extracted from the chamber. Infiltration is performed at a temperature lying in the range 960.degree. C. to 1050.degree. C., and preferably in the range 1000.degree. C. to 1030.degree. C., under a total pressure of not more than 25 kPa, and preferably equal to 7 kPa to 12 kPa, and the concentration of silicon-containing species in the residual gas is lowered at the outlet from the infiltration chamber, e.g. by injecting an inert gas (via 70).

Abstract: A material is impregnated with an aqueous solution containing precursors of a glass-containing phosphate base modified at least by the presence of zinc oxide, then dried and heat treated to form an internal oxidation protection constituted by the modified phosphate glass-containing base. The precursors are introduced into the aqueous solution so as to form a glass-containing base in which the molar ratio between the glass modifying oxides, comprising zinc oxide, and the glass forming oxides, principally comprising or consisting of phosphoric anhydride, is sufficiently high, in particular at least 0.6, preferably 0.9, to confer a resistance to corrosion by moisture on the glass-containing phosphate base.

Abstract: Each friction face of a brake disk (10) is masked (plates 40, 46) to isolate and seal the exterior from liquids, and the disk is immersed in a bath (30) of impregnating composition containing at least one substance which can form a protective layer against oxidation. Impregnation is effected by establishing a pressure difference between the pressure at the exterior of the exposed surfaces of the immersed brake disk (10) and the pressure inside the internal open pore space of the brake disk, without completely evacuating the latter, to force the impregnating composition to penetrate into the internal open pore space of the disk to a certain depth from the exposed surfaces, to form an internal oxidation protection. The pressure difference is adjusted depending on the desired depth of penetration of the impregnating composition into the internal open pore space.

Abstract: The process is particularly well suited to the manufacture of composite materials, where a fibrous reinforcement texture is to be impregnated by a densifying matrix, and comprises the steps of:preparing a slurry containing a solid charge in the form of finely divided particles dispersed in a carrier liquid, which preferably contains an organic compound,placing a substrate inside an enclosure,creating a vacuum inside the enclosure, andcausing the slurry to pass through the substrate by means of a pressure difference.Uniformity of charge integration is ensured by forcing the slurry to pass through the substrate several times, in successively opposite directions. The concentration of solid charge in the slurry can be determined as a function of an intended charge percentage by volume in said substrate.

Abstract: The manufacture of a refractory composite material protected against corrosion and comprising fibrous reinforcement densified by a matrix, comprises a step of forming, either within the matrix or at its surface, at least one continuous layer constituted by a ternary silicon-boron-carbon system obtained by chemical vapor deposition or infiltration. The elements silicon and boron are thereby distributed uniformly, with the boron content in the Si-B-C system being not less than 5% in atom percentage.