Patents by Inventor Jacques Simiand

Jacques Simiand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5468750
    Abstract: A compound of formula ##STR1## in which A represents S;R.sub.1 is selected from the group consisting of OH, (C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy, benzyloxy, phenyl, benzyl (C.sub.1 -C.sub.4)alkyl NZ.sub.1 Z.sub.2, and NZ.sub.1 Z.sub.2 ;R.sub.2 is selected from the group consisting of OH, SH, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, and NZ.sub.1 Z.sub.2 ;R.sub.3 is selected from the group consisting of H, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkoxy, phenyl, and benzyl;B is selected from the group consisting of phenyl; pyridyl; phenyl substituted by one or more groups selected from halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, CF.sub.3, CH.sub.2 NZ.sub.1 Z.sub.2, and NZ.sub.1 Z.sub.2 wherein Z.sub.1 and Z.sub.2 are selected, independently of each other, from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, formyl, and benzyl or --NZ.sub.1 Z.sub.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: November 21, 1995
    Assignee: Elf Sanofi
    Inventors: Andre Bachy, Laurent Fraisse, Peter Keane, Etienne Mendes, Jean-Claude Vernieres, Jacques Simiand
  • Patent number: 5360799
    Abstract: Compounds of formula ##STR1## in which R.sub.1 represents OH, (C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy, benzyloxy, benzyl, phenyl, (C.sub.1 -C.sub.4)alkylNZ.sub.1 Z.sub.2 or NZ.sub.1 Z.sub.2 ; R.sub.2 represents OH, SH, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio or NZ.sub.1 Z.sub.2 ; R.sub.3 represents H, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkoxy, phenyl or benzyl; A represents N and R represents H or (C.sub.1 -C.sub.4)alkyl which can be substituted by phenyl or NZ.sub.1 Z.sub.2 ; B represents phenyl which is coupled to the pyridyl ring and is optionally substituted by one or more groups chosen from halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, CF.sub.3, CH.sub.2 NZ.sub.1 Z.sub.2 or NZ.sub.1 Z.sub.2 ; and Z.sub.1 and Z.sub.2 represent, independently of each other, H, (C.sub.1 -C.sub.6) alkyl, formyl or benzyl, or they form with the nitrogen atom to which they are attached an optionally substituted saturated heterocycle and their salts.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: November 1, 1994
    Assignee: Elf Sanofi
    Inventors: Andre Bachy, Laurent Fraisse, Peter Keane, Etienne Mendes, Jean-Claude Vernieres, Jacques Simiand
  • Patent number: 5270341
    Abstract: The invention concerns a method of treatment and prophylaxis of depression and stress by means of a phenylethanolaminotetralin of formula (I) ##STR1## wherein A is a (C.sub.1 -C.sub.4)alkylene radical and R represents a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, or a pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 4, 1991
    Date of Patent: December 14, 1993
    Assignee: Elf Sanofi
    Inventors: Peter-Eugene Keane, Alberto Bianchetti, Jacques Simiand, Tiziano Croci
  • Patent number: 5026716
    Abstract: A method of treatment of anxiety and depression in mammals is described which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine derivative of formula I ##STR1## wherein Alk represents a straight or branched (C.sub.1 -C.sub.4)alkylene chain and R is selected from the group consisting of cyano, acetyl, (C.sub.3 -C.sub.7)cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: June 25, 1991
    Assignee: Sanofi
    Inventors: Alberto Bianchetti, Gerard Le Fur, Jacques Simiand, Philippe Soubrie
  • Patent number: 4835163
    Abstract: The present invention concerns new derivatives of 4-oxo-1,4-dihydro-quinoline 3-carboxamide, answering to the following general formula: ##STR1## in which: R.sub.1 represents a linear or branched lower alkyl radical, containing from 1 to 5 carbon atoms; an alkenyl or alkynyl radical containing from 2 to 5 carbon atoms; or a cycloalkyl radical containing from 3 to 5 carbon atoms,R.sub.2 represents an alkyl radical containing from 1 to 4 carbon atoms, n is equal to 1 or 2,X represents a hydrogen, a halogen, a lower alkoxy or alkyl group.The invention also concerns their application as medicaments and the compositions containing them.
    Type: Grant
    Filed: January 15, 1987
    Date of Patent: May 30, 1989
    Assignee: Sanofi
    Inventors: Jean-Claude Verniere, Jacques Simiand, Peter E. Keane
  • Patent number: 4788188
    Abstract: The present invention relates to new quinolylglycinamide derivatives corresponding to the following general formula: ##STR1## The invention also relates to a process for preparing these compounds and their therapeutic application as a psychotropic agent.
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: November 29, 1988
    Assignee: Sanofi (S.A.)
    Inventors: Jean-Claude Vernieres, Etienne Mendes, Michel Morre, Peter Keane, Jacques Simiand
  • Patent number: 4283420
    Abstract: The chemical compounds of the invention are useful as the active compound in drugs because of their anticonvulsant and/or antianoxic activity. They have the general formula ##STR1## wherein Z is a hydroxyl group; a group--OM wherein M is an alkali metal atom or an equivalent atom fraction of an alkaline-earth metal or an amino group such as --NH.sub.2, and R is a linear or branched alkyl group containing from 1 to 9 carbon atoms, and optionally substituted by one or more halogen atoms; a linear or branched alkenyl or alkynyl, alkoxyalkyl, or acylalkyl group containing from 2 to 9 carbon atoms and optionally substituted by one or more halogen atoms; an aryl or arylalkyl or aryloxyalkyl group comprising at least one aromatic radical and an alkyl chain having from 1 to 4 carbon atoms.
    Type: Grant
    Filed: April 18, 1979
    Date of Patent: August 11, 1981
    Assignee: Labaz
    Inventors: Charles Pigerol, Jean-Claude Vernieres, Pierre Eymard, Jacques Simiand, Madeleine Broll, Jean-Yves Lacolle
  • Patent number: 4115401
    Abstract: Prostaglandin derivatives corresponding to the general formula: ##STR1## wherein R.sub.1 represents hydrogen, methyl or ethyl, R.sub.2, R.sub.3 and R.sub.4, which are the same or different, each represent hydrogen or methyl and R is selected from the groups consisting of: ##STR2## in which R.sub.5 represents hydrogen, methyl or ethyl, R.sub.6 represents methyl, ethyl or acetyl and R.sub.7 and R.sub.8, when they are different, each represent hydrogen or a branched- or straight-chain alkyl group having from 1 to 7 carbon atoms or R.sub.7 and R.sub.8, when they are identical, each represent hydrogen or a straight-chain alkyl group having from 1 to 3 carbon atoms with the provisos that:When both R.sub.7 and R.sub.8 represent hydrogen, R.sub.5 is methyl or ethyl,When R.sub.5 represents methyl and R.sub.2, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 all represent hydrogen then R.sub.1 is ethyl,The said prostaglandin derivatives being in the form of a mixture of isomers or of an individual isomer.
    Type: Grant
    Filed: March 31, 1977
    Date of Patent: September 19, 1978
    Assignee: Labaz
    Inventors: Souli Nanthavong, Charles Pigerol, Pierre Eymard, Jacques Simiand