Patents by Inventor Jacques Tonnel

Jacques Tonnel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 3-substituted (indol-1-yl)-acetic acid esters
    Patent number: 9828359
    Abstract: The invention relates to an industrial scale process for the preparation of a compound of general formula (I): (Formula (I)) wherein R1, R2 and R3 are as defined herein. The process comprises reacting compounds of general formulae (II) and (III): (formulae (II), (III)) in the presence of a Lewis acid followed by a reduction with triethylsilane.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: November 28, 2017
    Assignee: Atopix Therapeutics Limited
    Inventors: Jacques Tonnel, Sylvie Blanchet, Guillaume Léonard Pierre Dewaele
  • Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-y1)-acetic acid esters
    Patent number: 9102658
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein R1 is C1C6 alkyl or benzyl by reacting a compound of formula (II) wherein R1 is as defined for formula (I) with 2-quinoline carboxaldehyde. The process is suitable for use on an industrial scale.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 11, 2015
    Assignee: Atopix Therapeutics Limited
    Inventors: Jacques Tonnel, Tony Pintus, Alain Burgos
  • Process for the Preparation of (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid Esters
    Publication number: 20140350264
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein R1 is C1C6 alkyl or benzyl by reacting a compound of formula (II) wherein R1 is as defined for formula (I) with 2-quinoline carboxaldehyde. The process is suitable for use on an industrial scale.
    Type: Application
    Filed: December 14, 2012
    Publication date: November 27, 2014
    Inventors: Jacques Tonnel, Tony Pintus, Alain Burgos
  • In situ or one-pot hydrogenation and reductive amination process
    Patent number: 7462742
    Abstract: An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I): and includes: a) the hydrogenation of a nitrile group of the compound of general formula (II): in which R1 to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; and b) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: December 9, 2008
    Assignee: Zach System
    Inventors: Alain Burgos, Jacques Tonnel, Valéry Dambrin, Denis Lucet, Patricia Poirier
  • In situ or one-pot hydrogenation and reductive amination process
    Publication number: 20080125606
    Abstract: An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I): and includes: a) the hydrogenation of a nitrile group of the compound of general formula (II): in which R1 to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; and b) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
    Type: Application
    Filed: January 23, 2007
    Publication date: May 29, 2008
    Applicant: PPG-SIPSY
    Inventors: Alain Burgos, Jacques Tonnel, Valerie Dambrin, Denis Lucet, Patricia Poirier