Abstract: A lighting structure for mounting a strip of LED's comprising a base member (10) having a channel (15) formed therein for receiving the strip (54) of LED's, a first member (22) of an attachment system extending along a portion of the base member (10), and a cover (34) having a second portion (42, 46) of an attachment system, said second portion (42, 46) of said attachment system mating with the first portion (22) of the attachment system to retain the cover (34) and base member (10) together and at least partially overlapping the channel to permit retention of the strip of LED's therein.

Abstract: A lighting structure for mounting a strip of LED's comprising a base member (10) having a channel (15) formed therein for receiving the strip (54) of LED's, a first member (22) of an attachment system extending along a portion of the base member (10), and a cover (34) having a second portion (42, 46) of an attachment system, said second portion (42, 46) of said attachment system mating with the first portion (22) of the attachment system to retain the cover (34) and base member (10) together and at least partially overlapping the channel to permit retention of the strip of LED's therein.

Abstract: The present invention relates to a method to treat a genetic disease in an individual caused by at least one frame shift or at least one non sense mutation in the human dystrophin gene comprising at least the step of bringing into contact at least one meganuclease enzyme, which recognizes and cuts a target site in the human dystrophin gene, with the genome of said individual under conditions wherein said at least one meganuclease recognizes and cleaves its target site in the human dystrophin gene. Said method applies also to a set of meganuclease enzymes, which each recognizes and cuts a different target site. The present invention also relates to a kit comprising, at least one meganuclease enzyme as defined above and medicament comprising said meganuclease.

Abstract: This invention relates to a dump valve for a liquid retaining tank having an outlet with a valve seat disposed over the outlet and a valve member displaceable between an open position spaced from the valve to release the liquid from the tank and a closed position for contacting the valve seat to seal the outlet, with an actuator to move the valve member between the open and closed positions. The valve member includes spaced upper and lower plates with deformable material there between to contact the valve seat. The upper plate also including stopper pins.

Abstract: The present invention relates to a method to treat a genetic disease in an individual caused by at least one frame shift or at least one non sense mutation in the human dystrophin gene comprising at least the step of bringing into contact at least one meganuclease enzyme, which recognizes and cuts a target site in the human dystrophin gene, with the genome of said individual under conditions wherein said at least one meganuclease recognizes and cleaves its target site in the human dystrophin gene. Said method applies also to a set of meganuclease enzymes, which each recognizes and cuts a different target site. The present invention also relates to a kit comprising, at least one meganuclease enzyme as defined above and medicament comprising said meganuclease.

Abstract: A method for obtaining cell populations derived from the muscular tissue and their use for preparing cell therapy products includes culturing cells previously removed by biopsy from skeletal muscular tissues, identifying the different types of cells present at different stages of culture, selecting the culture stage on the basis of the required cell population and collecting the selected culture stage for preparing a cell therapy product. The invention also concerns cell populations derived from muscular tissue obtained by implementing the method whereof the dominant cell type is CD34+, CD15+ or CD56+ or Class 1+HLA, or comprises a doubly negative CD56?/CD15? cell type or may comprise more minority CD10+, Stro-1+ and CD 117+ cell types.

Abstract: Methods of pretreating healthy donor's myoblast cultures with growth or trophic factors on transplantation into subjects suffering from myopathic conditions such as muscular dystrophy. Compositions comprising myoblasts and fusion-promoting metalloproteases can be transplanted. Alternatively, myoblasts can be transplanted along with an agent inducing the expression of a fusion-promoting metalloprotease, or a composition comprising genetically-modified myoblasts capable of expressing a fusion-promoting metalloprotease can be transplanted.

Abstract: The invention relates to methods and materials for enhancing muscle mass or for the treatment of muscle disease in a subject, comprising introducing a cell which has a lower than normal level of myostatin signalling, into the subject.

Abstract: A programmable traffic light unit includes traffic signal means for producing a traffic signal, a signal control input for receiving a control signal from an intersection traffic controller, and a logic module coupled to the traffic signal means and the signal control input. The control signal is configured to control the timing of the traffic signal. The logic module is configured to control the traffic signal, and is also configured to configure the traffic signal from a programming command received over the signal control input.

Abstract: A method for obtaining cell populations derived from the muscular tissue and their use for preparing cell therapy products includes culturing cells previously removed by biopsy from skeletal muscular tissues, identifying the different types of cells present at different stages of culture, selecting the culture stage on the basis of the required cell population and collecting the selected culture stage for preparing a cell therapy product. The invention also concerns cell populations derived from muscular tissue obtained by implementing the method whereof the dominant cell type is CD34+, CD15+ or CD56+ or Class 1+ HLA, or comprises a doubly negative CD56?/CD15? cell type or may comprise more minority CD10+, Stro-1+ and CD117+ cell types.

Abstract: The present invention relates to a method for preconditioning healthy donor's myoblasts in vitro before transplantation thereof in compatible patients suffering of recessive myopathies, particularly of muscular dystrophy. This in vitro preconditioning improves the success of the transplantation while not requiring an in vivo preconditioning of the patient's muscle by irradiation or by administering muscular toxin. The invention further relates to compositions comprising such preconditioned myoblasts. The preconditioning comprises pre-treating the transplanted myoblasts with human fibroblast growth factor (bFGF). The transplantation is made with the whole culture along with bFGF. A concentration of 100 ng/ml bFGF improved the myoblasts fusion by a four fold average.

Abstract: A method for obtaining cell populations derived from the muscular tissue and their use for preparing cell therapy products includes culturing cells previously removed by biopsy from skeletal muscular tissues, identifying the different types of cells present at different stages of culture, selecting the culture stage on the basis of the required cell population and collecting the selected culture stage for preparing a cell therapy product. The invention also concerns cell populations derived from muscular tissue obtained by implementing the method whereof the dominant cell type is CD34+, CD15+ or CD56+ or Class 1+ HLA, or comprises a doubly negative CD56−/CD15− cell type or may comprise more minority CD10+, Stro-1+ and CD117+ cell types.

Abstract: Telephone Device for the Deaf (TDD transitive) for a computing system and method of encoding and decoding TDD signals are described. The apparatus includes a sound card enabled to transmit and receive TDD coded Frequency Keying modulated audio signals. In extracting characters from a received audio signal, the sound card is used to sample the received audio signal. In extracting data bits from the received audio signal, groups of samples representing portions of the received signal are correlated against two frequencies.