Patents by Inventor Jacquin C. Niles

Jacquin C. Niles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers
    Patent number: 9125931
    Abstract: In vitro SELEX has been used to discover high affinity RNA aptamers interacting with the tetracycline repressor protein in a tetracycline-dependent manner. Using in silico RNA folding predictions to guide the design of both aptamer truncations and mutants, minimized tetracycline repressor protein high affinity binding aptamers have been defined. Using one such aptamer, inducible post-transcriptional regulation in vivo has been demonstrated that is predicated on a direct interaction between a tetracycline repressor protein and a RNA aptamer element. These aptamer components can be integrated in any organism to inducibly regulate RNA translation of a gene of interest.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: September 8, 2015
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Brian J. Belmont, Stephen J. Goldfless, Michael A. Marletta, Jacquin C. Niles
  • Post-Transcriptional Regulation Of RNA-Related Processes Using Encoded Protein-Binding RNA Aptamers
    Publication number: 20110245326
    Abstract: In vitro SELEX has been used to discover high affinity RNA aptamers interacting with the tetracycline repressor protein in a tetracycline-dependent manner. Using in silico RNA folding predictions to guide the design of both aptamer truncations and mutants, minimized tetracycline repressor protein high affinity binding aptamers have been defined. Using one such aptamer, inducible post-transcriptional regulation in vivo has been demonstrated that is predicated on a direct interaction between a tetracycline repressor protein and a RNA aptamer element. These aptamer components can be integrated in any organism to inducibly regulate RNA translation of a gene of interest.
    Type: Application
    Filed: April 6, 2010
    Publication date: October 6, 2011
    Inventors: Brian J. Belmont, Stephen J. Goldfless, Michael A. Marletta, Jacquin C. Niles