Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: A femoral guide for use in implanting a knee prosthesis. The femoral guide includes a cutting guide, and a referencing guide coupled to the cutting guide and adapted for locating a femoral joint line.

Abstract: Disclosed is a modular femoral sizing guide which facilitates the selection and rotational orientation of a femoral prosthetic for a resected femur. The femoral sizing guide has a base which is coupled to the resected femur. An extension portion which is configured to have a pair of feet which are coupled to the posterior surface of the resected femur is rotatably coupled to the base portion. A superstructure having a pair of drilling guides and a stylus is slidably coupled to the base.

Abstract: A modular knee prosthesis includes a femoral stem having a proximal end portion. A femoral component includes a first engagement portion defined thereon wherein the femoral stem is selectively attachable to the first engagement portion of the femoral component. A connecting member includes a first end selectively attachable to the first engagement portion of the femoral component and includes a second engagement portion defined on a second end wherein the femoral stem is selectively attachable to the second engagement portion of the connecting member.

Abstract: Disclosed is a modular femoral sizing guide which facilitates the selection and rotational orientation of a femoral prosthetic for a resected femur. The femoral sizing guide has a base which is coupled to the resected femur. An extension portion which is configured to have a pair of feet which are coupled to the posterior surface of the resected femur is rotatably coupled to the base portion. A superstructure having a pair of drilling guides and a stylus is slidably coupled to the base.

Abstract: A holder for a femoral component. The holder includes a clamp adapted to engage an intercondylar feature of the femoral component and one of medial or lateral surfaces of the femoral component.

Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

Abstract: A modular component for a knee joint prosthesis is disclosed. The modular component includes a tray, a stem and an adapter assembly. The tray includes a support surface and downwardly extending extension having a generally circular shape. The stem includes a main body portion and an upwardly extending extension. The adapter assembly connects the tray and the stem. The adapter assembly includes a first generally cylindrical cavity receiving the downwardly extending extension of the tray and a second generally cylindrical cavity receiving the upwardly extension of the stem.

Abstract: A punch assembly for preparing a tibia bone for a prosthesis includes a static component configured to be supported by the tibia bone and a dynamic component that includes a punch having a stem. The dynamic component is supported for movement relative to the static component along a generally arcuate path to prepare an aperture having an arcuate contour in the tibia bone. A method of preparing a tibial aperture for is also disclosed.

Abstract: A knee implantation system for replacing a portion of a knee joint includes an unicondyler tibial implant configured to replace a portion of a tibia that includes a first member and a second member. The first member has a body portion that includes an articulating surface for replacing only a single superior articulating surface of the tibia. The second member has a textured surface. The second member is removably connected to the body portion and the textured surface is disposed about opposite the articulating surface.

Abstract: A tissue repair device. The tissue repair device includes a tubular shaft having a longitudinal bore for delivering biological material to a soft tissue defect, and an awl having a distal end configured for microfracturing bone underlying the defect. The tubular shaft and the awl are movable relative to one another such that the awl is at least partially positioned within the longitudinal bore of the tubular shaft.

Abstract: A modular tibial component for a knee joint prosthesis. The modular tibial component includes a tray, a stem and an adapter assembly. The tray includes a support surface and downwardly extending extension having a generally circular shape. The stem includes a main body portion and an upwardly extending extension. The adapter assembly connects the tray and the stem. The adapter assembly includes a first generally cylindrical cavity receiving the downwardly extending extension of the tray and a second generally cylindrical cavity receiving the upwardly extension of the stem.

Abstract: An articulating bearing knee including a guide post that in a first orientation allows substantially free varus and valgus distraction, but in another constrains the same. The guide post in includes a superior portion that engages a femoral component of a knee prosthesis in a rotated orientation. When the guide post engages the femoral component it may not distract as if it was not engaged. This allows for a control and constraint of such distraction when the knee is rotated and in a weaker position.

Abstract: A modular tibial component for a knee joint prosthesis. The modular tibial component includes a tray, a stem and an adapter assembly. The tray includes a support surface and downwardly extending extension having a generally circular shape. The stem includes a main body portion and an upwardly extending extension. The adapter assembly connects the tray and the stem. The adapter assembly includes a first generally cylindrical cavity receiving the downwardly extending extension of the tray and a second generally cylindrical cavity receiving the upwardly extension of the stem.

Abstract: An articulating bearing knee including a guide post that in a first orientation allows substantially free varus and valgus distraction, but in another constrains the same. The guide post in includes a superior portion that engages a femoral component of a knee prosthesis in a rotated orientation. When the guide post engages the femoral component it may not distract as if it was not engaged. This allows for a control and constraint of such distraction when the knee is rotated and in a weaker position.

Abstract: A modular tibial component for a knee joint prosthesis. The modular tibial component includes a tray, a stem and an adapter assembly. The tray includes a support surface and downwardly extending extension having a generally circular shape. The stem includes a main body portion and an upwardly extending extension. The adapter assembly connects the tray and the stem. The adapter assembly includes a first generally cylindrical cavity receiving the downwardly extending extension of the tray and a second generally cylindrical cavity receiving the upwardly extension of the stem.