Patents by Inventor Jadwiga Kaleta

Jadwiga Kaleta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydropyrimidine derivatives as cysteine protease inhibitors
    Publication number: 20040024000
    Abstract: Ditiydropyrimidine derivatives are disclosed, which can be used to inhibit cysteine protease activity.
    Type: Application
    Filed: April 11, 2003
    Publication date: February 5, 2004
    Inventors: Rajeshwar Singh, Andhe V.N. Reddy, Nian E. Zhou, Qizhu Ding, George Thomas, Jadwiga Kaleta, Ronald G. Micetich
  • Cysteine protease inhibitors
    Patent number: 6635621
    Abstract: This invention relates to derivatives of alpha-amino acid amides, to pharmaceutical compositions containing such compounds, and to their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins. A compound of formula (I) is described or a pharmaceutically acceptable salt, hydrate or solvate thereof. Pharmaceutically acceptable salts of the compounds of this invention include the sodium, potassium, magnesium, calcium, hydrogen chloride, tartaric acid, succinic acid, fumaric acid and p-toluenesulfonic acid salts.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: October 21, 2003
    Assignee: Naeja Pharmaceutical Inc.
    Inventors: Rajeshwar Singh, Nian Zhou, Andhe V. N. Reddy, George Thomas, Qizhu Ding, Jadwiga Kaleta, Ronald George Micetich, Mark Whittaker
  • Substituted azetidin-2-ones as cysteine protease inhibitors
    Patent number: 6569847
    Abstract: This invention relates to substituted azetidin-2-ones and to pharmaceutical compositions containing such compounds. Their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins is also described. The invention includes a compound of formula (I), Y represents —C(O)— or —S(O2)—; R represents an allyl (ie CH2═CHCH2—) group or a radical. R1 represents —OCOR5, —OR5, —SR5, —S(O)R5, or —S(O)2R5; R2 represents a radical. R3 represents —OR5 or R5; or a pharmaceutically acceptable salt, hydrate or solvate thereof.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: May 27, 2003
    Assignee: NAEJA Pharmaceuticals Inc.
    Inventors: Rajeshwar Singh, Andhe V. Narender Reddy, Jadwiga Kaleta, Ronald G. Micetich, Mark Whittaker, Philip Huxley
  • 3-Substituted-4-oxa-1-azabicyclo ?3,2,0!heptan-7-one as cysteine protease inhibitors
    Patent number: 5925633
    Abstract: The use of certain 3-substituted-4-oxa-1-azabicyclo?3,2,0! heptan-7-one derivatives of general formula I, ##STR1## or physiologically acceptable salts thereof or isomers thereof, as active ingredients for the preparation of pharmaceutical composition and treatment of different diseases associated with deregulation of cysteine proteases is disclosed.
    Type: Grant
    Filed: March 6, 1996
    Date of Patent: July 20, 1999
    Assignee: Synphar Laboraties, Inc.
    Inventors: Rajeshwar Singh, Nian E. Zhou, Deqi Guo, Jadwiga Kaleta, Ronald George Micetich
  • 6-substituted amino-4-oxa-1-azabicyclo ?3,2,0! heptan-7-one derivatives as cysteine protease inhibitors
    Patent number: 5905076
    Abstract: Novel 6-substituted amino-4-oxa-1-azabicyclo?3,2,0!heptan-7-one compounds, as well as the pharmaceutically acceptable salts thereof and diastereoisomers thereof, of formula I, ##STR1## are disclosed, which exhibit excellent cysteine protease inhibitory activity and may be used for treatment of different diseases such as muscular dystrophy, arthritis, myocardial infarction, Alzheimer's disease, bacterial infection, common cold, osteroporosis and cancer metastasis.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: May 18, 1999
    Assignee: National Research Council of Canada
    Inventors: Rajeshwar Singh, Nian E. Zhou, Degi Guo, Alan Cameron, Jadwiga Kaleta, Enrico Purisima, Robert Menard, Ronald George Micetich