Abstract: Disclosed is an alpha alumina (?-Al2O3) thin film comprising the lower layer formed on the base material made from cemented carbide; and the ?-Al2O3 thin film layer formed on the lower layer, wherein when the ?-Al2O3 thin film layer is divided, from the total thickness (T) thereof, into a D1 layer which is from an interface layer to 0.15T, a D2 layer which is from 0.15T to 0.4T, and a D3 layer which is from 0.4T to 1T, an S1 (D3 layer grain size/D1 layer grain size) is 2-5.5 and an S2 (D2 layer grain size/D1 layer grain size) is 1.5-4.

Abstract: Provided is a hard film for a cutting tool formed on a surface of a base material, the hard film being comprised of a nano multi-layered structure formed by sequentially stacking a thin layer A, a thin layer B, a thin layer C and a thin layer D or being comprised of a structure formed by repeatedly stacking the nano multi-layered structure at least twice, wherein the thin layer A is comprised of TixAl1-xN (0.5?x?0.7); the thin layer B is comprised of Al1-y-zTiyMezN (0.4?y?0.7, 0<z?0.1 where Me is at least one of Si, Cr, and Nb); the thin layer C is comprised of AlaTi1-aN (0.5?a?0.7); and the thin layer D is comprised of AlbCr1-bN (0.5?b?0.7).

Abstract: The present invention relates to phthalazinone derivatives, including pharmaceutical compositions and for the preparation of phthalazinone derivatives. And more particularly the present invention provided a pharmaceutical composition of phthalazinone derivatives for inhibiting activity of the Poly(ADP-riboside) polymerase enzyme.

Abstract: Provided is a hard film formed on a surface of a base material, the hard film being comprised of a nano multi-layered structure formed by stacking a thin layer A, a thin layer B a thin layer C in order of thin layers A-B-A-C from the base material or being comprised of a structure formed by repeatedly stacking the nano multi-layered structure at least twice, wherein the thin layer A is comprised of Ti1-xAlxN (0.3?x?0.7); the thin layer B is comprised of Al1-yCryN (0.3?y?0.7); and the thin layer C is comprised of MeN (where Me is any one of Nb, V, and Cr).

Abstract: Provided is a hard film for a cutting tool formed on a surface of a base material, the hard film being comprised of a nano multi-layered structure comprising a thin layer A, a thin layer B, a thin layer C and a thin layer D or a structure in which the nano multi-layered structure is repeatedly stacked at least twice, wherein the thin layer A is comprised of Ti1-xAlxN (0.5?x?0.7); the thin layer B is comprised of Al1-y-zTiyCrzN (0.3?y?0.6 and 0<z?0.3); the thin layer B is comprised of MeN (where Me is Nb or V); and the thin layer D is comprised of Al1-a-bTiaSibN (0.3?a?0.7 and 0<b<0.1).

Abstract: A method for hyaluronic acid having a low degradation rate in a subject body includes culturing Streptococcus dysgalactiae strain 9103 (KCTC11818BP) in a medium including a carbon source and a nitrogen source.

Abstract: Provided is a multilayer thin film for a cutting tool, in which micro-scale thin films having a thickness of a few nanometers to tens of nanometers are alternately stacked, having less quality variations and being capable of realizing excellent wear resistance. The multilayer thin film according to the present disclosure is a multilayer thin film for a cutting tool, in which unit thin films which are respectively formed of thin layers A, B, C, and D are stacked more than once, wherein elastic moduluses k of the thin layers satisfy relationships of kA>kB, kD>kC or kC>kB, kD>kA, lattice parameters L of the thin layers satisfy relationships of LA, LC>LB, LD or LB, LD>LA, LC, and a difference between maximum and minimum values of the lattice parameter L is 20% or less.

Abstract: Provided is a hard film for a cutting tool formed on a surface of a base material, the hard film being comprised of a nano multi-layered structure formed by sequentially stacking a thin layer A, a thin layer B, a thin layer C and a thin layer D or being comprised of a structure formed by repeatedly stacking the nano multi-layered structure at least twice, wherein the thin layer A is comprised of TixAl1-xN (0.5?x?1.7); the thin layer B is comprised of Al1-y-zTiyMezN (0.4?y?0.7, 0<z?0.1 where Me is at least one of Si, Cr, and Nb); the thin layer C is comprised of AlaTi1-aN (0.5?a?0.7); and the thin layer D is comprised of AlbCr1-bN (0.5?b?0.7).

Abstract: Provided is a hard film for a cutting tool formed on a surface of a base material, the hard film being comprised of a nano multi-layered structure comprising a thin layer A, a thin layer B, a thin layer C and a thin layer D or a structure in which the nano multi-layered structure is repeatedly stacked at least twice, wherein the thin layer A is comprised of Ti1-xAlxN (0.5?x?0.7); the thin layer B is comprised of Al1-y-zTiyCrzN (0.3?y?0.6 and 0<z?0.3); the thin layer B is comprised of MeN (where Me is Nb or V); and the thin layer D is comprised of Al1-a-bTiaSibN (0.3?a?0.7 and 0<b<0.1).

Abstract: Provided is a hard film formed on a surface of a base material, the hard film being comprised of a nano multi-layered structure formed by stacking a thin layer A, a thin layer B a thin layer C in order of thin layers A-B-A-C from the base material or being comprised of a structure formed by repeatedly stacking the nano multi-layered structure at least twice, wherein the thin layer A is comprised of Ti1-xAlxN (0.3?x?0.7); the thin layer B is comprised of Al1-yCryN (0.3?y?0.7); and the thin layer C is comprised of MeN (where Me is any one of Nb, V, and Cr).

Abstract: Provided is a Streptococcus dysgalactiae ID9103 strain having accession number KCTC11818BP, and a method of producing hyaluronic acid by culturing the strain to produce hyaluronic acid having an average molecular weight of 10,000,000 Da or more.

Abstract: Provided is a Streptococcus dysgalactiae ID9103 strain having accession number KCTC11818BP, and a method of producing hyaluronic acid by culturing the strain to produce hyaluronic acid having an average molecular weight of 10,000,000 Da or more.

Abstract: The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method.

Abstract: The present invention discloses a multi-layer hard film for an indexable insert. The multi-layer hard film for the indexable insert provided by the present invention is formed by sequentially depositing a base layer, an intermediate layer and a top layer with different composition ratios and film structures individually on the indexable insert, thus minimizing a delamination and tool wear which may occur in high speed machining.

Abstract: Disclosed are a novel 5-membered heterocycle derivatives of Formula I, a tautomer, pharmaceutically acceptable salt, prodrug thereof and a pharmaceutical use thereof. The 5-membered heterocycle derivatives of Formula I, a tautomer, pharmaceutically acceptable salt, prodrug thereof and compositions containing them are useful for treating a tumor.

Abstract: The present invention relates to a method for preparing low molecular weight hyaluronic acid from high molecular weight hyaluronic acid which is produced by Streptococcus sp. ID9102 (KCTC11395BP). The method of the invention for lowering a molecular weight of high molecular hyaluronic acid has a convenient process without the inconvenience of reprocessing for the removal of input materials, or requiring pH treatment, various reaction catalysts, and complicated additional treatment conditions as in a conventional method. The inventive method for lowering the molecular weight has an advantage in that according to a change of a reaction condition using activated carbon, the molecular weight of low molecular weight hyaluronic acid can be variously adjusted. The low molecular weight hyaluronic acid produced by the method of the invention can be produced in accordance with the standards of cosmetics or foods as well as medical supplies.

Abstract: The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method.

Abstract: The present invention discloses a multi-layer hard film for an indexable insert. The multi-layer hard film for the indexable insert provided by the present invention is formed by sequentially depositing a base layer, an intermediate layer and a top layer with different composition ratios and film structures individually on the indexable insert, thus minimizing a delamination and tool wear which may occur in high speed machining.

Abstract: The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient.

Abstract: The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient.