Abstract: The present application provides a single-chain blood coagulation factor VIII including a B region which is partially deleted to contain at least four glycosylation sites, but not a region to be cleaved by furin, or a single-chain blood coagulation factor VIII in which the A or B region has some residues pegylated. A single-chain blood coagulation factor VIII according to the present application not only retains intact therapeutic efficacy and can be easily produced on mass scale because of its single chain form, but also has an increased half-life in vivo through pegylation, thus enhancing convenience for patients as a therapeutic agent for hemophilia A and bringing about a reduction of medical expenses through reduction in production cost.

Abstract: A chimera protein according to the present application has a significantly increased in vivo half-life when administered because of a vWF domain coupled to FVIII, such that when used as a hemophilia A therapeutic agent, convenience for patients can be increased and medical expenses can be reduced.

Abstract: An in-vivo release-sustained recombinant coagulation factor VIII and a method for making it are disclosed. The recombinant coagulation factor VIII has a biocompatible polymer that is conjugated to at least one sugar chain terminus. The in-vivo release-sustained recombinant coagulation factor VIII has a protein surface modified through a method more elaborate and safer than conventional glycoconjugation techniques and enjoys the advantage of decreasing in immunogenicity and increasing in in-vivo sustainability.

Abstract: A chimera protein according to the present application has a significantly increased in vivo half-life when administered because of a vWF domain coupled to FVIII, such that when used as a hemophilia A therapeutic agent, convenience for patients can be increased and medical expenses can be reduced.

Abstract: The present invention relates to a speaker. The speaker comprises a first cabinet 20 with a predetermined inner space 22 defined therein; a second cabinet 30 in which an inner space 32 communicating with the inner space 22 of the first cabinet 20 is defined so that the inner space 22 is closed from the outside when the second cabinet 30 is engaged with the first cabinet 20; and a sound-generating unit 40 provided in the inner spaces 22 and 32 defined by the first and second cabinets 20 and 30 to generate an acoustic signal. The first and second cabinets 20 and 30 can move relatively with respect to each other, whereby an internal volume of the inner spaces 22 and 32 is changed through adjustment of the length D of the inner spaces 22 and 32 between a front end of the first cabinet 20 and a rear end of the second cabinet 30.