Patents by Inventor Jae-Ick Sim
Jae-Ick Sim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8669078Abstract: Disclosed herein are ammonia-specific 5?-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5?-XMP aminase. The resulting 5?-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5?-XMP into 5?-GMP. Thus, the ammonia-specific 5?-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5?-XMP into 5?-GMP.Type: GrantFiled: December 14, 2006Date of Patent: March 11, 2014Assignee: CJ Cheiljedang CorporationInventors: Jae-Gu Pan, Heung-Chae Jung, Eui-Joong Kim, Han-Seung Lee, Young Hoon Park, Hyoung Suk Kim, Jong-Kwon Han, Jin Nam Lee, Ki-Hoon Oh, Jeong Hwan Kim, Yoon-Suk Oh, Jae Ick Sim, Kuk-Ki Hong, Kyung Oh Choi, Hyun Soo Kim, Min-Ji Baek, Tae Sun Kang
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Patent number: 8551736Abstract: A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed.Type: GrantFiled: January 2, 2009Date of Patent: October 8, 2013Assignee: CJ Cheiljedang Corp.Inventors: Chul Ha Kim, Jong Soo Choi, Jeong Hwan Kim, Hyoung Seok Kim, Jung Gun Kwon, Tae Min Ahn, Soo Youn Hwang, Jae Ick Sim, Min Ji Baek, Na Ra Kwon, Hye Jin Choi
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Publication number: 20110003342Abstract: A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed.Type: ApplicationFiled: January 2, 2009Publication date: January 6, 2011Applicant: CJ CHEILJEDANG CORP.Inventors: Chul Ha Kim, Jong Soo Choi, Jeong Hwan Kim, Hyoung Seok Kim, Jung Gun Kwon, Tae Min Ahn, Soo Youn Hwang, Jae Ick Sim, Min Ji Baek, Na Ra Kwon, Hye Jin Choi
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Patent number: 7741101Abstract: Provided are mutant strains derived from Escherichia sp. GPU1114 (Accession No. KCCM-10536), having cumulative inactivation of deoD, aphA, appA, and hprt genes, and methods of using the same.Type: GrantFiled: January 20, 2006Date of Patent: June 22, 2010Assignee: CJ Cheiljedang CorporationInventors: Young-hoon Park, Hyoung-suk Kim, Jin-nam Lee, Ko-hoon Oh, Jeong-hwan Kim, Yoon-suk Oh, Jae-ick Sim, Kyung-oh Choi
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Patent number: 7662943Abstract: Provided are a promoter including at least one polynucleotide selected from the group consisting of SEQ ID NOS: 1 to 7, an expression cassette including the same, a vector including the expression cassette, a host cell including the vector, and a method of expressing a gene using the host cell.Type: GrantFiled: December 16, 2005Date of Patent: February 16, 2010Assignee: CJ Cheiljedang CorporationInventors: Young-Hoon Park, Hyun-Soo Kim, Hye-Jin Choi, Jin-Ho Lee, Soo-Youn Hwang, Jae-Ick Sim, Tae-Sun Kang, Won-Sik Lee
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Patent number: 7608435Abstract: The invention relates to a microorganism, obtained by treating Corynebacterium ammoniagenes KCCM 10488 producing 5?-Xanthylic acid as parent strain with UV radiation and mutation Derivatives such as N-methyl-N?nitro-N-nitrosoguanidine (NTG), Having a resistance to 5-fluorotryptophan which enhances Biosynthesis of N5-N10-tetrahydrofolate used for transferring Two formyl group during the process of puring biosynthesis, making It possible to accumulate 5?xanthylic acid in culture medium at a high Yield and high concentration rate same period of fermentation.Type: GrantFiled: November 18, 2004Date of Patent: October 27, 2009Assignee: CJ Cheiljedang Corp.Inventors: Young-Hoon Park, Jea-Young Chang, Jin-Nam Lee, Ki-Hoon Oh, Jeong-Hwan Kim, Yoon-Suk Oh, Jae-Ick Sim
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Publication number: 20080318278Abstract: Disclosed herein are ammonia-specific 5?-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5?-XMP aminase. The resulting 5?-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5?-XMP into 5?-GMP. Thus, the ammonia-specific 5?-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5?-XMP into 5?-GMP.Type: ApplicationFiled: December 14, 2006Publication date: December 25, 2008Applicant: CJ CHEILJEDANG CORPORATIONInventors: Jae-Gu Pan, Heung-Chae Jung, Eui-Joong Kim, Han-Seung Lee, Young Hoon Park, Hyoung Suk Kim, Jong-Kwon Han, Jin Nam Lee, Ki-Hoon Oh, Jeong Hwan Kim, Yoon-Suk Oh, Jae Ick Sim, Kuk-Ki Hong, Kyung Oh Choi, Hyun Soo Kim, Min-Ji Baek, Tae Sun Kang
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Publication number: 20080299620Abstract: Provided are mutant strains derived from Escherichia sp. GPU1114 (Accession No. KCCM-10536), having cumulative inactivation of deoD, aphA, appA, and hprt genes, and methods of using the same.Type: ApplicationFiled: January 20, 2006Publication date: December 4, 2008Applicant: CJ CORP.Inventors: Young-hoon Park, Hyoung-suk Kim, Jin-nam Lee, Ki-hoon Oh, Jeong-hwan Kim, Yoon-suk Oh, Jae-ick Sim, Kyung-oh Choi
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Patent number: 7456010Abstract: The invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 producing 5?-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 which is a mutant strain of Corynebacterium ammoniagenes KCCM 10340 having a resistance to osmotic pressure. In order to obtain mutant strain having enhanced respiratory activity, the present invention adopted Corynebacterium ammoniagenes KCCM 10340 as parent strain and treated it with UV radiation and mutation derivatives such as N-methyl-N?-nitro-n-nitrosoguanidine (NTG) according to ordinary procedure. Therefore, Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 of the present invention makes it possible to overcome growth-standing phase rapidly on early culture and for same period of fermentation, can accumulate 5?-xanthylic acid in culture medium at a high yield and concentration rate.Type: GrantFiled: December 10, 2003Date of Patent: November 25, 2008Assignee: CJ Cheiljedang Corp.Inventors: Young-Hyeon Kwag, Ki-Hoon Oh, Jeong-Hwan Kim, Yoon-Suk Oh, Jae-Ick Sim, Young-Hoon Park, Jea-Young Chang
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Publication number: 20080138859Abstract: Provided are a promoter including at least one polynucleotide selected from the group consisting of SEQ ID NOS: 1 to 7, an expression cassette including the same, a vector including the expression cassette, a host cell including the vector, and a method of expressing a gene using the host cell.Type: ApplicationFiled: December 16, 2005Publication date: June 12, 2008Applicant: CJ CORPORATIONInventors: Young-Hoon Park, Hyun-Soo Kim, Hye-Jin Choi, Jin-Ho Lee, Soo-Youn Hwang, Jae-Ick Sim, Tae-Sun Kang, Won-Sik Lee
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Publication number: 20070141682Abstract: The invention relates to a microorganism, obtained by treating Corynebacterium ammoniagenes KCCM 10488 producing 5?-Xanthylic acid as parent strain with UV radiation and mutation Derivatives such as N-methyl-N?nitro-N-nitrosoguanidine (NTG), Having a resistance to 5-fluorotryptophan which enhances Biosynthesis of N5-N10-tetrahydrofolate used for transferring Two formyl group during the process of puring biosynthesis, making It possible to accumulate 5?xanthylic acid in culture medium at a high Yield and high concentration rate same period of fermentation.Type: ApplicationFiled: November 18, 2004Publication date: June 21, 2007Inventors: Young-Hoon Park, Jea-Young Chang, Jin-Nam Lee, Ki-Hoon Oh, Jeong-Hwan Kim, Yoon-Suk Oh, Jae-Ick Sim
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Patent number: 7217558Abstract: The invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 producing 5?-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 which is a mutant strain of Corynebacterium ammoniagenes KCCM 10340 having a resistance to oligomycin. In order to obtain mutant strain having enhanced respiratory activity, the present invention adopted Corynebacterium ammoniagenes KCCM 10340 as parent strain and treated it with UV radiation and mutation derivatives such as N-methyl-N?-nitro-n-nitrosoguanidine(NTG) according to ordinary procedure. Therefore, Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 of the present invention makes it possible to increase ATP reproducing activity for same period of fermentation and can accumulate 5?xanthylic acid in culture medium at a high yield and concentration rate.Type: GrantFiled: December 10, 2003Date of Patent: May 15, 2007Assignee: CJ CorporationInventors: Young-Hyeon Kwag, Ki-Hoon Oh, Jeong-Hwan Kim, Yoon-Suk Oh, Jae-Ick Sim, Young-Hoon Park, Jea-Young Chang
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Publication number: 20060154346Abstract: The invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 producing 5?-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 which is a mutant strain of Corynebacterium ammoniagenes KCCM 10340 having a resistance to oligomycin. In order to obtain mutant strain having enhanced respiratory activity, the present invention adopted Corynebacterium ammoniagenes KCCM 10340 as parent strain and treated it with UV radiation and mutation derivatives such as N-methyl-N?-nitro-n-nitrosoguanidine(NTG) according to ordinary procedure. Therefore, Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 of the present invention makes it possible to increase ATP reproducing activity for same period of fermentation and can accumulate 5?xanthylic acid in culture medium at a high yield and concentration rate.Type: ApplicationFiled: December 10, 2003Publication date: July 13, 2006Inventors: Young-Hyeon Kwag, Ki-Hoon Oh, Jeong-Hwan Kim, Yoon-Suk Oh, Jae-Ick Sim, Young-Hoon Park, Jea-Young Chang
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Publication number: 20060094084Abstract: The invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 producing 5?-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 which is a mutant strain of Corynebacterium ammoniagenes KCCM 10340 having a resistance to osmotic pressure. In order to obtain mutant strain having enhanced respiratory activity, the present invention adopted Corynebacterium ammoniagenes KCCM 10340 as parent strain and treated it with UV radiation and mutation derivatives such as N-methyl-N?-nitro-n-nitrosoguanidine (NTG) according to ordinary procedure. Therefore, Corynebacterium ammoniagenes CJXSP 0201 KCCM 10448 of the present invention makes it possible to overcome growth-standing phase rapidly on early culture and for same period of fermentation, can accumulate 5?-xanthylic acid in culture medium at a high yield and concentration rate.Type: ApplicationFiled: December 10, 2003Publication date: May 4, 2006Inventors: Young-Hyeon Kwag, Ki-Hoon Oh, Jeong-Hwan Kim, Yoon-Suk Oh, Jae-Ick Sim, Young-Hoon Park, Jea-Young Chang
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Patent number: 6821768Abstract: The invention relates to microorganism producing 5′-xanthylic acid. A 3,4-dehydro-DL-proline resistant Corynebacterium ammoniagenes CJXPK001 strain is provided for producing 5′-xanthylic acid. It is a mutant strain of Corynebacterium ammoniagenes KFCC 10743 having a lower resistance to 3,4-dehydro-DL-proline. The mutant strain is not affected by osmotic pressure caused by accumulated, highly concentrated solute in a culture medium, and it can produce 5′-xanthylic acid at a high yield and concentration rate.Type: GrantFiled: December 19, 2002Date of Patent: November 23, 2004Assignee: CJ CorporationInventors: Jeong-Hwan Kim, Young-Hyeon Kwag, Jang-Hee Park, Eun-Sung Koh, Yoon-Suk Oh, Jea-Young Chang, Kwang-Ho Lee, Jae-Ick Sim, Jong-Kwon Han, Young-Hoon Park
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Publication number: 20030148498Abstract: The invention relates to microorganism producing 5′-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXPK001 which is a mutant strain of Corynebacterium ammoniagenes KFCC 10743 having a resistance to 3,4-dehydro-DL-proline.Type: ApplicationFiled: December 19, 2002Publication date: August 7, 2003Inventors: Jeong-Hwan Kim, Young-Hyeon Kwag, Jang-Hee Park, Eun-Sung Koh, Yoon-Suk Oh, Jea-Young Chang, Kwang-Ho Lee, Jae-Ick Sim, Jong-Kwon Han, Young-Hoon Park