Abstract: A tooth extraction tool to sever through a periodontal ligament for atraumatic extraction of a tooth in humans is provided. The tool includes an elongated handle with two ends. The tool further includes a blade attached to one end of the elongated handle. The blade flexes to adapt to the shape of the periodontal ligament when the blade is vertically moved between the alveolar bone and the tooth to be extracted along selected tooth surfaces. The vertical movement of the blade relays an axial force to sever the periodontal ligament.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: The present invention relates, in general to agents that modulate the pharmacological activity of siRNAs. In addition, the invention relates generally to methods and systems for use in assessing the efficacy and safety of a pharmaceutical composition for use in the treatment or prophylaxis of a disease.

Abstract: A precision handling system including a gripper, a flexure, and a ball transfer. The gripper includes a first jaw and a second jaw configured to provide a gripping force therebetween for gripping and moving an object. The flexure is coupled to the gripper and configured to provide compliance in at least one direction. The ball transfer is coupled to the gripper. The ball transfer includes a ball configured to engage the object to transfer the gripping force thereto and configured to spherically rotate to allow the object to move with respect to the first jaw.

Abstract: A non-oriented electrical steel sheet according to an embodiment of the present invention includes: in wt %, C at 0.004 wt % or less (excluding 0 wt %), Si at 2.5 to 4.0 wt %, P at 0.1 wt % or less (excluding 0 wt %), Al at 0.3 to 2.0 wt %, N at 0.003 wt % or less (excluding 0 wt %), S at 0.003 wt % or less (excluding 0 wt %), Mn at 0.15 to 2.5 wt %, Cr at 0.5 wt % (excluding 0 wt %), and the balance including Fe and other impurities unavoidably added thereto; satisfies the following Equation 1; and has an average grain size of 20 ?m or less. [Mn]?1450×[S]?0.8??[Equation 1] (In Equation 1, [Mn] and [S] represent a content (wt %) of Mn and S, respectively.).

Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.

Abstract: The present invention relates, in general to agents that modulate the pharmacological activity of siRNAs. In addition, the invention relates generally to methods and systems for use in assessing the efficacy and safety of a pharmaceutical composition for use in the treatment or prophylaxis of a disease.

Abstract: A heat exchange module, comprising an array of microchannels, where the array of microchannels extends in a first direction, and are separated from one another by a first sidewall. The array of microchannels is over a cold plate. A first array of fluid distribution channels is stacked over the array of microchannels and extend in a second direction that is substantially orthogonal to the first direction. The first array of fluid distribution channels extends from the first manifold and terminate between a first manifold and a second manifold. A second array of fluid distribution channels is stacked over the array of microchannels. The first array of fluid distribution channels and the second array of the fluid distribution channels are fluidically coupled to the microchannel array. A wall extends into the microchannel array below a second sidewall separating ones of the first array and ones of the second array of fluid distribution channels.

Abstract: A refrigerator is provided having at least one internal refrigerated compartment in which a plurality of refrigeration zones are provided, wherein an environment in each refrigeration zone may be independently controlled using a user interface configured to receive a zone selection input from a user indicating one of the plurality of refrigeration zones in which the user desires to adjust the environment; a plurality of lights provided in the internal refrigerated compartment and disposed proximate to each of the plurality of refrigeration zones, wherein groups of the plurality of lights may be separately controlled for visually identifying each of the refrigeration zones; and a controller configured to receive a zone selection input from the user interface, identify a group of the plurality of lights that are disposed proximate the selected refrigeration zone, and control the identified group of the plurality of lights to visually confirm the selected refrigeration zone.

Abstract: The present invention relates, in general to agents that modulate the pharmacological activity of siRNAs. In addition, the invention relates generally to methods and systems for use in assessing the efficacy and safety of a pharmaceutical composition for use in the treatment or prophylaxis of a disease.

Abstract: The present invention relates to methods of inhibiting the expression of an AGT gene in a subject, as well as methods for treating subjects having an AGT-associated disorder, e.g., hypertension, using RNAi agents, e.g., double stranded RNAi agents, targeting the AGT gene. The invention also relates to methods of decreasing blood pressure levels in a subject using such RNAi agents to inhibit expression of an AGT gene.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: A non-contact handler includes an upper body portion and a lower body portion movably coupled to the upper body portion. The lower body portion includes a non-contact puck configured to lift an object and a plurality of containment fences extending downward from the puck. The plurality of containment fences are arranged around a periphery of the object to be lifted.

Abstract: A method of issuing blockchain-based digital certificates associated with a gemstone comprising receiving from a user a plurality of gemstone records, each record of the plurality of gemstone records comprising a characteristic indicator associated with a gemstone, receiving from the user meta-information related to the plurality of gemstone records, applying a hashing function to each record of the plurality of gemstone records, generating a plurality of fingerprints, generating a hash tree from the plurality of fingerprints, the hash tree comprising a root hash, recording to a digital certificate gemstone smart contract deployed at a digital certificate gemstone smart contract address on a first blockchain network the root hash and the received meta-information, and signing the digital certificate gemstone smart contract with an issuer signature.

Abstract: An oriented electrical steel sheet according to an exemplary embodiment of the present invention includes C: 0.01% or less (excluding 0%), Si: 2.0%-4.0%, Mn: 0.01%-0.20%, acid soluble Al: 0.040% or less (excluding 0%), N: 0.008% (excluding 0%), S: 0.008% (excluding 0%), Se: 0.0001-0.008%, Cu: 0.002-0.1%, Ni: 0.005-0.1%, Cr: 0.005-0.1%, P: 0.005%-0.1% and Sn: 0.005%-0.20%, one or more among Sb: 0.0005%-0.10%, Ge: 0.0005%-0.10%, As: 0.0005%-0.10%, Pb: 0.0001%-0.10%, Bi: 0.0001%-0.10% and Mo: 0.001-0.1% as wt %, and consisting of the balance of Fe and other inevitable impurities, and after final secondary recrystallization, a magnetic flux density B8 is 1.92 Tesla or more.

Abstract: A non-oriented electrical steel sheet according to an embodiment of the present invention includes: in wt %, C at 0.004 wt % or less (excluding 0 wt %), Si at 2.5 to 4.0 wt %, P at 0.1 wt % or less (excluding 0 wt %), Al at 0.3 to 2.0 wt %, N at 0.003 wt % or less (excluding 0 wt %), S at 0.003 wt % or less (excluding 0 wt %), Mn at 0.15 to 2.5 wt %, Cr at 0.5 wt % (excluding 0 wt %), and the balance including Fe and other impurities unavoidably added thereto; satisfies the following Equation 1; and has an average grain size of 20 ?m or less. [Mn]?1450×[S]?0.8??[Equation 1] (In Equation 1, [Mn] and [S] represent a content (wt %) of Mn and S, respectively.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: A blockchain-based rough gemstone planning method including receiving a gemstone record including gemstone scan information and a smart contract, receiving a plurality of virtual derivative gemstones that may be derived from a gemstone associated with the received gemstone record and a plurality of virtual derivative gemstone records comprising meta-information about the virtual derivative gemstones, recording the plurality of virtual derivative gemstone records to a meta-information database, generating a plurality of derivative smart contracts associated with the plurality of virtual derivative gemstone records, sending the virtual derivative gemstone records and the derivative smart contracts, receiving price information for the plurality of virtual derivative gemstone records, and identifying a subset of the plurality of virtual derivative gemstone records that may be derived from the gemstone associated with received gemstone record responsive to the received price information received.

Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.

Abstract: The disclosed computer-implemented method may include (1) receiving a video with scenes, (2) creating an encoded video having an overall bitrate by (a) determining, for each of the scenes, a rate-distortion model, (b) determining, for each of the scenes, a downsampling-distortion model, (c) using the rate-distortion models of the scenes to determine, for each of the scenes, a per-scene bitrate that satisfies the overall bitrate, (d) determining, for each of the scenes, a per-scene resolution for the scene based on the rate-distortion model of the scene and the downsampling-distortion model of the scene, and (e) creating, for each of the scenes, an encoded scene having the per-scene bitrate of the scene and the per-scene resolution of the scene, and (3) streaming the encoded video at the overall bitrate by streaming the encoded scene of one of the scenes. Various other methods, systems, and computer-readable media are also disclosed.