Patents by Inventor Jae-Kyu Roh

Jae-Kyu Roh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of neurodegenerative diseases by targeting miRNA
    Patent number: 9301969
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: April 5, 2016
    Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Jae-Kyu Roh, Sang Kun Lee, Man Ho Kim, Kon Chu, Keun-Hwa Jung, Soon-Tae Lee
  • METHOD AND PHARMACEUTICAL COMPOSITION COMPRISING ADIPOSE STEM CELL EXTRACT FOR TREATING OR PREVENTING NEUROLOGIC DISEASE
    Publication number: 20150209390
    Abstract: The present disclosure provides adipose cell extracts and its use. The composition comprising the present extracts and method can be used advantageously for a stem cell-based, noninvasive therapy for treating neurologic disease such as stroke and HD. Also, in contrast to the stem cell transplantation, the present method or composition enables the repeated treatments, due to the convenient administration, thus leading to a more efficient prevention and/or curing of the disease of interest.
    Type: Application
    Filed: January 23, 2015
    Publication date: July 30, 2015
    Applicant: SNU R&DB FOUNDATION
    Inventors: Kon CHU, Jae-Kyu ROH, Manho KIM, Sang Kun LEE, Keun-Hwa JUNG, Soon-Tae LEE, Daejong JEON, Wooseok IM, Jae-Jun BAN
  • TREATMENT OF NEURODEGENERATIVE DISEASES BY TARGETING MIRNA
    Publication number: 20130184331
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.
    Type: Application
    Filed: September 9, 2011
    Publication date: July 18, 2013
    Applicant: SNU R&DB FOUNDATION
    Inventors: Jae-Kyu Roh, Sang Kun Lee, Man Ho Kim, Kon Chu, Keun-Hwa Jung, Soon-Tae Lee