Abstract: The present invention relates to a high strength synthetic bone for bone replacement for increasing compressive strength and facilitating blood circulation, and a manufacturing method therefor, and provides the high strength synthetic bone for bone replacement in which calcium sulfate hemihydrate (CSH) and NaCl, in a particle state, penetrate into the pores of a porous inorganic material such as ?-tricalcium phosphate (?-TCP) and a wet treatment is performed on the same such that the CSH penetrated into the pores is combined with moisture so as to form a hydrated crystal of calcium sulfate dihydrate (CSD) to expand the volume thereof in the pores, thereby preventing the escape of a filler by physical force.