Abstract: The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

Abstract: A method for manufacturing an engine intake manifold assembly is provided. The method includes forming a top, middle, and bottom section of the manifold assembly in an injection molding process, each including cavities defined with positive draft angles, the cavities defining a plurality of internal passageways in an assembled state of the manifold assembly. The top, middle, and bottom sections are joined to form the manifold assembly through vibration welding or ultrasonic welding. An engine intake manifold assembly having top, middle, and bottom sections joined through vibration welding or ultrasonic welding is also provided.