Patents by Inventor Jae-Ryeon Ryu

Jae-Ryeon Ryu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting a substance having an activity to inhibit HIV infection using immunoassay and variant protein used for said method
    Patent number: 6294341
    Abstract: The present invention relates to a method for detecting a substance having an activity to inhibit HIV infection rapidly, economically and safely. The present invention uses the characteristics that if a function of transmembrane protein gp41 of HIV is inhibited, HIV infection is also inhibited, and therefore the function of gp41 depends on the interaction between two helical structures of gp41. The method of the present invention is to detect a substance to inhibit HIV infection by an immunoassay using the interaction between the variant protein Trx-N, which is prepared by binding the N-terminal helical domain of gp41 to Trx (thioredoxin) and the variant protein GST-C, which is prepared by binding the C-terminal helical domain of gp41 with GST-C (Glutathione S-transferase). This immunoassay can be used for automatic detection of the substance to inhibit the activity of gp41 can be carried out by the method.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: September 25, 2001
    Assignee: Korea Institute of Science and Technology
    Inventors: Yeon Gyu Yu, Sung-Hou Kim, Jae-Ryeon Ryu