Patents by Inventor Jae-Sung Yi

Jae-Sung Yi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230036788
    Abstract: The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described.
    Type: Application
    Filed: August 30, 2022
    Publication date: February 2, 2023
    Inventors: Anton BENNETT, Jae-Sung YI
  • Patent number: 11458137
    Abstract: The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: October 4, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Anton Bennett, Jae-Sung Yi
  • Publication number: 20200009142
    Abstract: The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described.
    Type: Application
    Filed: September 19, 2019
    Publication date: January 9, 2020
    Inventors: Anton BENNETT, Jae-Sung YI
  • Patent number: 10471059
    Abstract: The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: November 12, 2019
    Assignee: Yale University
    Inventors: Anton Bennett, Jae-Sung Yi
  • Publication number: 20180271864
    Abstract: The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described.
    Type: Application
    Filed: January 26, 2016
    Publication date: September 27, 2018
    Inventors: Anton BENNETT, Jae-Sung YI
  • Patent number: 8837730
    Abstract: An apparatus and a method reduce delay when reproducing digital broadcasting in a mobile terminal. More particularly, the apparatus and method reduce a reproduction delay, from having to stand by until an encrypted stream that matches with a traffic key is received, by receiving the traffic key in advance prior to the encrypted stream when a mobile terminal receives encrypted broadcasting. The apparatus includes a controller. The controller receives and stores a traffic key corresponding to an encrypted channel even when not entering the encrypted channel, and deciphers and reproduces the relevant channel using the stored traffic key when entering the encrypted channel.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: September 16, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Ji-Wuck Jung, Young-Jip Kim, Joon-Ho Park, Jin-Woo Jeon, Jae-Sung Yi
  • Patent number: 8383602
    Abstract: The present invention relates to a new use of TRIM72 as a target for muscle enhancer and heart enhancer, more particularly to a composition for enhancing muscle or heart comprising an expression or action inhibitor of TRIM72 protein. The present invention further relates to a new TRIM mutant protein inducing muscle differentiation and hypertrophy and its gene. The inventors of the present invention have identified that TRIM72 overexpression inhibits myogenesis whereas TRIM72 knockdown enhances myogenesis, and first elucidated that TRIM72 is a negative regulator of skeletal muscle differentiation. Accordingly, the inhibition of TRIM72 acts exclusively on skeletal muscle and heart muscle, but does not affect IGF-I signaling pathway in other tissues.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: February 26, 2013
    Assignee: Korea University Industrial & Academic Collaborative Foundation
    Inventors: Young-Gyu Ko, Jae-Sung Yi, Chang-Seok Lee
  • Publication number: 20110251256
    Abstract: The present invention relates to a new use of TRIM72 as a target for muscle enhancer and heart enhancer, more particularly to a composition for enhancing muscle or heart comprising an expression or action inhibitor of TRIM72 protein. The present invention further relates to a new TRIM mutant protein inducing muscle differentiation and hypertrophy and its gene. The inventors of the present invention have identified that TRIM72 overexpression inhibits myogenesis whereas TRIM72 knockdown enhances myogenesis, and first elucidated that TRIM72 is a negative regulator of skeletal muscle differentiation. Accordingly, the inhibition of TRIM72 acts exclusively on skeletal muscle and heart muscle, but does not affect IGF-I signaling pathway in other tissues.
    Type: Application
    Filed: September 4, 2008
    Publication date: October 13, 2011
    Applicant: KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATIVE FOUNDATION
    Inventors: Young-Gyu Ko, Jae-Sung Yi, Chang-Seok Lee
  • Publication number: 20110069838
    Abstract: An apparatus and a method reduce delay when reproducing digital broadcasting in a mobile terminal. More particularly, the apparatus and method reduce a reproduction delay, from having to stand by until an encrypted stream that matches with a traffic key is received, by receiving the traffic key in advance prior to the encrypted stream when a mobile terminal receives encrypted broadcasting. The apparatus includes a controller. The controller receives and stores a traffic key corresponding to an encrypted channel even when not entering the encrypted channel, and deciphers and reproduces the relevant channel using the stored traffic key when entering the encrypted channel.
    Type: Application
    Filed: September 21, 2010
    Publication date: March 24, 2011
    Applicant: Samsung Electronics Co., Ltd.
    Inventors: Ji-Wuck Jung, Young-Jip Kim, Joon-Ho Park, Jin-Woo Jeon, Jae-Sung Yi