Abstract: Provided is a biofeedback device using an electrocardiogram, and the biofeedback device using an electrocardiogram may include: a signal acquisition unit acquiring an electrocardiogram signal of a user from an electrocardiograph; an analysis unit analyzing the acquired electrocardiogram signal and providing a state diagnosis result of the user as an analysis result; and a control unit controlling at least one stimulation unit among a plurality of stimulation units for state control of the user based on the state diagnosis result, and a stimulation corresponding to the at least one stimulation unit may be provided to the user by the control of the control unit.

Abstract: Provided is an electrocardiogram lead guide system. The electrocardiogram lead guide system may include: an electrocardiograph attached to a part of a body of a patient and acquiring posture information and electrocardiogram signals using a plurality of sensors; and a user terminal providing guide information for guiding the attachment direction of the electrocardiograph based on the posture information.

Abstract: A novel process for preparing risedronate sodium hemipentahydrate represented by the following formula 1 using 2-(3-pyridyl)-1-hydroxyethane-1,1-bisphosphonic acid (risedronic acid) and an aqueous solution of risedronate sodium is disclosed.

Abstract: Disclosed herein is a novel method for preparing lercanidipine hydrochloride which is highly effective for treating hypertension. The method comprises the steps of reacting 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with a substituted chlorophosphate derivative to obtain a substituted phosphonoester derivative, and reacting the substituted phosphonoester derivative with 2, N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol. According to the preparation method, since little by-products are formed, the yield is improved, as compared to cases of conventional methods. In addition, the method involves simple isolation and purification processes of lercanidipine, thus realizing a high-quality product. Furthermore, the method has advantages of low preparation costs, substantial waste-free environmental-friendly process and applicability to industrial mass-production.

Abstract: A novel process for preparing risedronate sodium hemipentahydrate represented by the following formula 1 using 2-(3-pyridyl)-1-hydroxyethane-1,1-bisphosphonic acid (risedronic acid) and an aqueous solution of risedronate sodium is disclosed.