Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.

Abstract: According to the present disclosure, there is provided a cell stimulation and culture platform using a ultrasonic hologram, including a culture vessel in which a culture well with an open lower portion is formed; a transmission sheet which is installed to cover a lower surface of the culture vessel and where a biological sample is seated; a platform body that is filled with a liquid medium and an open upper end is covered by the transmission sheet; an ultrasonic transducer that is installed inside the platform body in a state of being spaced apart from the biological sample; and an ultrasonic hologram lens that is installed on the ultrasonic transducer, and spatially modulates the phase of the ultrasonic waves using a surface structure designed to have different height distributions to focus the ultrasonic waves in a set pattern shape on a target surface on which the biological sample is located.

Abstract: An imaging system according to an embodiment may include an ultrasonic oscillation part configured to apply ultrasonic waves to a sample, an image acquisition part configured to acquire a plurality of images of the sample deformed by the ultrasonic waves, and a computation part configured to compute a deformation rate on the basis of a change in thickness of the sample from the plurality of images, in which the computation part computes an elastic modulus of the sample on the basis of intensity of the ultrasonic waves and the deformation rate of the sample.

Abstract: Disclosed is a mobile autoscope system including: a user terminal device including a camera configured to capture an image of a capture target; and a mobile autoscope detachably mounted on the user terminal device, and configured to emit each of spectral light, ultraviolet (UV) light, or white light to the capture target, wherein the user terminal device is configured to capture the capture target during the emission of spectral light, UV light, or white light to generate a spectral image, a UV excitation fluorescence image, or a three-dimensional (3D) shape image.

Abstract: An imaging system according to an embodiment may include an ultrasonic oscillation part configured to apply ultrasonic waves to a sample, an image acquisition part configured to acquire a plurality of images of the sample deformed by the ultrasonic waves, and a computation part configured to compute a deformation rate on the basis of a change in thickness of the sample from the plurality of images, in which the computation part computes an elastic modulus of the sample on the basis of intensity of the ultrasonic waves and the deformation rate of the sample.

Abstract: Disclosed are an ultrasound imaging system for analysis of a body composition and an operation method of an ultrasound imaging system which is designed for analysis of a body composition. An ultrasound imaging system may include: a scan device into which an object is insertable; an ultrasonic probe connected to a part of the scan device; a controller configured to control the ultrasonic probe to emit a transmission ultrasonic signal to the object at multiple positions at the scan device, and receive a reflection ultrasonic signal reflected from the object; and an image processor configured to generate multiple 2D ultrasound images based on reflection ultrasonic signals received at the multiple positions at the scan device, respectively, and generate a 3D ultrasound image based on the multiple 2D ultrasound images.

Abstract: A probe includes a working channel, at least one optical element provided in the working channel and configured to acquire a spectral image of surface information of an object, and an ultrasonic transducer arranged in the working channel and configured to acquire an ultrasonic image of depth information of the target and move with respect to the at least one optical element.

Abstract: According to the present disclosure, there is provided a cell stimulation and culture platform using a ultrasonic hologram, including a culture vessel in which a culture well with an open lower portion is formed; a transmission sheet which is installed to cover a lower surface of the culture vessel and where a biological sample is seated; a platform body that is filled with a liquid medium and an open upper end is covered by the transmission sheet; an ultrasonic transducer that is installed inside the platform body in a state of being spaced apart from the biological sample; and an ultrasonic hologram lens that is installed on the ultrasonic transducer, and spatially modulates the phase of the ultrasonic waves using a surface structure designed to have different height distributions to focus the ultrasonic waves in a set pattern shape on a target surface on which the biological sample is located.

Abstract: Disclosed are a bladder monitoring apparatus which accurately determines a bladder status of a subject based on an ultrasonic image and a posture of the subject and a method for controlling the bladder monitoring apparatus. The bladder monitoring apparatus includes a processor, a memory configured to operably connected to the processor and store at least one code executed by the processor, and a transceiver configured to receive a reflection ultrasonic signal from a subject and a posture sensing signal obtained by sensing a posture of the subject based on a sensor, and the memory may store a code which is executed by the processor to cause the processor to determine the bladder status of the subject by applying the machine learning-based learning model to an ultrasonic image generated from the reflection ultrasonic signal and posture information generated based on the posture sensing signal.

Abstract: Disclosed are an ultrasound imaging system for analysis of a body composition and an operation method of an ultrasound imaging system which is designed for analysis of a body composition. An ultrasound imaging system may include: a scan device into which an object is insertable; an ultrasonic probe connected to a part of the scan device; a controller configured to control the ultrasonic probe to emit a transmission ultrasonic signal to the object at multiple positions at the scan device, and receive a reflection ultrasonic signal reflected from the object; and an image processor configured to generate multiple 2D ultrasound images based on reflection ultrasonic signals received at the multiple positions at the scan device, respectively, and generate a 3D ultrasound image based on the multiple 2D ultrasound images.

Abstract: A smart screw according to an embodiment may comprise: a screw main body which penetrates an artificial joint including a shell disposed on a hip joint of an object and a liner disposed on the inner surface of the shell and is then inserted into the hip joint; a transducer including a coupling layer that senses a sound wave signal reflected from the liner, a piezo-electric layer formed to determine a frequency of the sound wave signal, and a sound absorbing layer for absorbing the sound wave signal; and a processing module for generating a sound wave signal toward the liner and receiving the sound wave signal sensed by the coupling layer, measuring the thickness of the liner on the basis of the received sound wave signal, and transferring data about the measured thickness of the liner to the outside.

Abstract: A multispectral imaging device in accordance with one embodiment comprises: an illumination unit for emitting LED lighting to the skin for skin illumination; and a detection unit for causing light reflected from the skin to be incident on a camera, wherein the illumination unit is arranged on the outer side of the detection unit, so that a path of the LED lighting emitted from the illumination unit is formed on the outer side of the detection unit, and a path of the light reflected from the skin is formed on the inner side of the detection unit.

Abstract: A smart screw according to an embodiment may comprise: a screw main body which penetrates an artificial joint including a shell disposed on a hip joint of an object and a liner disposed on the inner surface of the shell and is then inserted into the hip joint; a transducer including a coupling layer that senses a sound wave signal reflected from the liner, a piezo-electric layer formed to determine a frequency of the sound wave signal, and a sound absorbing layer for absorbing the sound wave signal; and a processing module for generating a sound wave signal toward the liner and receiving the sound wave signal sensed by the coupling layer, measuring the thickness of the liner on the basis of the received sound wave signal, and transferring data about the measured thickness of the liner to the outside.

Abstract: Disclosed is a position indicating apparatus including a main body, a first arm connected to one side of the main body based on a symmetric axis of the main body, a second arm connected to another side of the main body based on the symmetric axis, a first light radiator connected to one end of the first arm to radiate a light, and a second light radiator connected to one end of the second arm to radiate a light, wherein the light radiated from the first light radiator and the light radiated from the second light radiator meet and form an intersection of line.

Abstract: A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.

Abstract: A probe includes a working channel, at least one optical element provided in the working channel and configured to acquire a spectral image of surface information of an object, and an ultrasonic transducer arranged in the working channel and configured to acquire an ultrasonic image of depth information of the target and move with respect to the at least one optical element.

Abstract: Provided are a mobile multispectral imaging device, a user terminal for acquiring a multispectral image, a spectral image analysis server, and a method thereof. A mobile multispectral imaging device, according to an embodiment of the present invention, is for taking spectral images for respective wavelengths by using a photographing unit of a user terminal. The mobile multispectral imaging device comprises: an optical system, positioned in a place corresponding to the photographing unit of the user terminal, which irradiates light to an object to be photographed, collects the light reflected from the object to be photographed, and transfers the light to the photographing unit; and a filter wheel, which is provided with a plurality of optical filters spaced apart from one another and positions one of the plurality of optical filters in an optical path according to rotation, wherein the plurality of optical filters filter an irradiated light in a specific wavelength.

Abstract: The present invention provides a mobile-based spectrum imaging device and a method for controlling the same. A mobile-based spectrum imaging device according to an embodiment of the present invention may comprise: an optical fiber for emitting, in a beam form, light which has been collected from a light source; a linear filter which is movably installed, divides the light emitted from the optical fiber into particular wavelength bands, and makes the divided light have a wavelength band changing according to the incidence location of the light; and a control unit for controlling the location of the linear filter such that the location of incident light is changed on the linear filter.