Patents by Inventor Jaechul Shim

Jaechul Shim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 9-aminocarbonylsubstituted derivatives of glycylcyclines
    Patent number: 8101590
    Abstract: This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): where Q, R4, R5, R6 and R10 and A are defined in the specification are useful as chemical intermediates.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: January 24, 2012
    Assignee: Wyeth LLC
    Inventors: Phaik-Eng Sum, Tarek Suhayl Mansour, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini, Jaechul Shim
  • Processes for the 3,3-dialkylation of 4-chromanones
    Patent number: 7671220
    Abstract: The present invention relates to methods for the preparation of 3,3-dialky 4-chromanones, and particularly to the preparation of 6-fluoro-3,3-dimethyl-2,3-dihydro-4H-chromen-4-one and 3,3-dimethyl-2,3-dihydro-4H-chromen-4-one. In some embodiments, the processes include reaction of a 4-chromanone compound with an alkyl halide in the presence of a metal alkoxide at low temperature.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: March 2, 2010
    Assignee: Wyeth
    Inventors: Ayako Yamashita, Emily B. Norton, Jaechul Shim, Cilien S. Hanna
  • 9-Aminocarbonylsubstituted derivatives of glycylcyclines
    Publication number: 20070049564
    Abstract: This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): where Q, R4, R5, R6 and R10 and A are defined in the specification are useful as chemical intermediates.
    Type: Application
    Filed: August 31, 2006
    Publication date: March 1, 2007
    Applicant: Wyeth
    Inventors: Phaik-Eng Sum, Tarek Mansour, David How, Darrin Hopper, Matthew Vera, Joshua Sabatini, Jaechul Shim
  • Processes for the 3,3-dialkylation of 4-chromanones
    Publication number: 20060183924
    Abstract: The present invention relates to methods for the preparation of 3,3-dialky 4-chromanones, and particularly to the preparation of 6-fluoro-3,3-dimethyl-2,3-dihydro-4H-chromen-4-one and 3,3-dimethyl-2,3-dihydro-4H-chromen-4-one. In some embodiments, the processes include reaction of a 4-chromanone compound with an alkyl halide in the presence of a metal alkoxide at low temperature.
    Type: Application
    Filed: February 15, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventors: Ayako Yamashita, Emily Norton, Jaechul Shim, Cilien Hanna
  • Amino acid-derived diaminopropanols
    Patent number: 6063963
    Abstract: The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized.The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: May 16, 2000
    Assignee: Pharm-Eco Laboratories, Inc.
    Inventors: Biman Pal, Siya Ram, Bing Cai, Yesh P. Sachdeva, Jaechul Shim, Salah A. Zahr, Emile Al-Farhan, Richard Gabriel
  • Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors
    Patent number: 5631405
    Abstract: The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized.This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: Pharm-Eco Laboratories, Incorporated
    Inventors: Biman Pal, Siya Ram, Bing Cai, Yesh P. Sachdeva, Jaechul Shim, Salah A. Zahr, Emile Al-Farhan, Richard L. Gabriel
  • Method forming protease inhibitor synthetic intermediates
    Patent number: 5618966
    Abstract: The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized.This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: April 8, 1997
    Assignee: Pharm-Eco Laboratories, Incorporated
    Inventors: Biman Pal, Siya Ram, Bing Cai, Yesh P. Sachdeva, Jaechul Shim, Salah A. Zahr, Emile Al-Farhan, Richard Gabriel
  • Amino acid-derived diaminopropanols
    Patent number: 5599994
    Abstract: The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized.The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 4, 1997
    Assignee: Pharm-Eco Laboratories, Inc.
    Inventors: Biman Pal, Siya Ram, Yesh P. Sachdeva, Jaechul Shim, Salah A. Zahr, Emile Al-Farhan, Richard L. Gabriel
  • Method preparing amino acid-derived diaminopropanols
    Patent number: 5475138
    Abstract: The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized.This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: December 12, 1995
    Assignee: Pharm-Eco Laboratories Incorporated
    Inventors: Biman Pal, Siya Ram, Bing Cai, Yesh P. Sachdeva, Jaechul Shim, Salah A. Zahr, Emile Al-Farhan, Richard Gabriel