Patents by Inventor Jae Gyun Oh

Jae Gyun Oh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Decoy peptides inhibiting protein phosphatase 1-medicated dephosphorylation of phospholamban
    Patent number: 10479816
    Abstract: The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2-X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: November 19, 2019
    Assignee: BETHPHAGEN INC.
    Inventors: Woo Jin Park, Roger J. Hajjar, Jae Gyun Oh
  • Decoy Peptides Inhibiting Protein Phosphatase 1-Medicated Dephosphorylation of Phospholamban
    Publication number: 20190112338
    Abstract: The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2-X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
    Type: Application
    Filed: December 18, 2018
    Publication date: April 18, 2019
    Inventors: Woo Jin PARK, Roger J. HAJJAR, Jae Gyun OH
  • Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban
    Patent number: 10208085
    Abstract: The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2—X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: February 19, 2019
    Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Woo Jin Park, Roger J. Hajjar, Jae Gyun Oh
  • DECOY PEPTIDES INHIBITING PROTEIN PHOSPHATASE 1-MEDIATED DEPHOSPHORYLATION OF PHOSPHOLAMBAN
    Publication number: 20150166603
    Abstract: The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2—X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
    Type: Application
    Filed: July 5, 2013
    Publication date: June 18, 2015
    Inventors: Woo Jin Park, Roger J. Hajjar, Jae Gyun Oh
  • Composition for Prevention or Treatment of Heart Failure
    Publication number: 20110245179
    Abstract: Provided are a composition for preventing or treating heart failure and a method for screening an agent for treating heart failure. The present disclosure demonstrates for the first time that administration of PKC? inhibitor provides inotropic effect by increasing myocardial contractility. Thus, the present disclosure will contribute greatly to the prevention or treatment of heart failure. Also, since the present disclosure is based on the change in calcium sensitivity in cardiac myocytes unlike the existing inotropic agents, it can enhance the myocardial contractility without increasing oxygen demand or the risk of arrhythmia.
    Type: Application
    Filed: September 17, 2009
    Publication date: October 6, 2011
    Inventors: Woo Jin Park, Jae Gyun Oh
  • Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban
    Patent number: RE48636
    Abstract: The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2—X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: July 13, 2021
    Assignee: BETHPHAGEN INC.
    Inventors: Woo Jin Park, Jae Gyun Oh