Patents by Inventor Jaehoon Yu

Jaehoon Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10308684
    Abstract: The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: June 4, 2019
    Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Jaehoon Yu, Soonsil Hyun, Yan Lee, Seonju Lee
  • Publication number: 20180339016
    Abstract: The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
    Type: Application
    Filed: September 19, 2016
    Publication date: November 29, 2018
    Inventors: Jaehoon Yu, Yan Lee, Soonsil Hyun, Seo Yeon Kim, Sun Mi Jin, Yunhwa Choi, Doyeon Jo, Seonju Lee
  • Publication number: 20170342108
    Abstract: The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.
    Type: Application
    Filed: November 27, 2015
    Publication date: November 30, 2017
    Inventors: Jaehoon Yu, Soonsil Hyun, Yan Lee, Seonju Lee
  • Publication number: 20160229894
    Abstract: The present invention relates to an ?-helical cell-penetrating peptide multimer, a preparation method thereof and the use thereof, and more particularly, to a peptide multimer comprising a plurality of amphipathic peptides, a method for preparing the peptide multimer, a composition for preventing or treating HIV, which comprises the peptide multimer as an active ingredient, and a composition for intracellular delivery of a biologically active substance, which comprises the peptide multimer and the biologically active substance.
    Type: Application
    Filed: October 17, 2014
    Publication date: August 11, 2016
    Applicant: Seoul National University R&DB Foundation
    Inventors: Jaehoon Yu, Yan Lee, Soonsil Hyun, Sangmok Jang
  • Publication number: 20120270771
    Abstract: The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically, the apolipoprotein A-1 mimic peptides of the present invention were manufactured by modifying hydrophilic or hydrophobic face of existing 4F amphipathic peptides to produce Apo A-I mimic peptides which specifically bind with cholesterol ester to allow high density lipoprotein content to increase, and the peptide of which phenylalanine in hydrophobic face of 4F is substituted with 2-naphthylalanine has superior cholesterol efflux capability and cognitive function for lipids to the existing 4F peptides, among the mimic peptides. Thus, the Apo A-I mimic peptides of the present invention can be used as Apo A-I mimic peptides and as a therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia.
    Type: Application
    Filed: September 30, 2009
    Publication date: October 25, 2012
    Applicant: SNU R&DB FOUNDATION
    Inventor: Jaehoon Yu
  • Patent number: 8084399
    Abstract: The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and hydrophobic face. The method of the present invention provides a screening method of an amphiphilic peptide which is specific to hairpin RNA. So, the peptide selected by the method of the present invention can be effectively used for the study of hairpin RNA functions and for the production of a novel drug using an artificial peptide binding to a hairpin RNA target.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: December 27, 2011
    Assignee: SNU R&DB Foundation
    Inventors: Jaehoon Yu, Jeffrey Kieft, Su Jin Lee
  • Publication number: 20110230367
    Abstract: The present invention relates to an amphiphilic peptide capable of promoting target miRNA production and a method for regulating the production of target miRNA using the same. In detail, the amphiphilic peptide of the present invention binds strongly and specifically to hairpin-shaped target miRNA. The specific binding affinity induces the Dicer enzyme activity, therefore specifically increase the production of target miRNA. The present invention can be effectively used for regulating the amount of target miRNA produced in vivo, for the study of miRNA functions and for producing therapeutic drug for target miRNA related disease.
    Type: Application
    Filed: November 23, 2009
    Publication date: September 22, 2011
    Applicant: SNU R&DB FOUNDATION
    Inventors: Jaehoon Yu, Vic Narry Kim, Soonsil Hyun
  • Patent number: 7999070
    Abstract: The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and nucleotide sequence and the investigation of functions of RNA using the selected peptides, and is very useful for the production of a new drug using synthetic peptide having more powerful and specific binding capacity to RNA than those of natural peptides.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: August 16, 2011
    Assignee: Seoul National University Industry Foundation
    Inventor: Jaehoon Yu
  • Patent number: 7799830
    Abstract: The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewer side-effects by showing no hormone properties, even when administered for a long period of time, and thus which can be used for neurodegenerative disease including dementia.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: September 21, 2010
    Assignees: Korea Institute of Science and Technology, Scigenic Co., Ltd.
    Inventors: Dong-Jin Kim, Kye-Jung Shin, Jaehoon Yu, Hee-Sul Lee
  • Publication number: 20100173796
    Abstract: The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and hydrophobic face. The method of the present invention provides a screening method of an amphiphilic peptide which is specific to hairpin RNA. So, the peptide selected by the method of the present invention can be effectively used for the study of hairpin RNA functions and for the production of a novel drug using an artificial peptide binding to a hairpin RNA target.
    Type: Application
    Filed: August 12, 2009
    Publication date: July 8, 2010
    Applicant: SNU R&DB Foundation
    Inventors: Jaehoon YU, Jeffrey Kieft, Su Jin Lee
  • Patent number: 7663081
    Abstract: The present invention provides a digital imaging photodetector with a gas electron multiplier. The digital imaging photodetector comprises a gas electron multiplier detector. The gas electron multiplier detector includes a photoelectric converter for converting incident light into photoelectrons or Compton electrons; a gas electron multiplier (GEM) for receiving the photoelectrons or Compton electrons from the photoelectric converter and multiplying them; and a readout unit for receiving an electrical signal indicating a position where an electron cloud multiplied in the gas electron multiplier arrives on an anode, recognizing coordinates of the electron cloud based on the received signal, and outputting the coordinates of the electron cloud.
    Type: Grant
    Filed: November 23, 2006
    Date of Patent: February 16, 2010
    Inventors: Chang Hie Hahn, Il-Gon Kim, Won-Jeong Kim, Jaehoon Yu
  • Publication number: 20090261265
    Abstract: An array gas electron multiplier (GEM) digital imaging radiation detector and a control method thereof are disclosed. The array gas electron multiplier (GEM) digital imaging radiation detector includes an array GEM detector. The array GEM detector includes: an ionized electron generation unit for generating ionized electrons in internal filling gas by incident X-rays or gamma rays or by incident charged particles; a gas electron multiplication unit for multiplying the ionized electrons of the ionized electron generation unit in filling gas inside hole of a gas electron multiplier (GEM), through electron avalanche effect, using the GEM, to form electron clouds; a readout for detecting and outputting coordinates of the electron clouds as the readout receives positions through electrical signals, in which the positions of the electron clouds, being multiplied and formed in the gas electron multiplication unit, reach output electrodes.
    Type: Application
    Filed: February 24, 2006
    Publication date: October 22, 2009
    Inventors: Chang Hie Hahn, Ii-Gon Kim, Seongtae Park, Jaehoon Yu
  • Publication number: 20080318797
    Abstract: The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and nucleotide sequence and the investigation of functions of RNA using the selected peptides, and is very useful for the production of a new drug using synthetic peptide having more powerful and specific binding capacity to RNA than those of natural peptides.
    Type: Application
    Filed: July 14, 2006
    Publication date: December 25, 2008
    Inventor: Jaehoon YU
  • Publication number: 20080283725
    Abstract: The present invention provides a digital imaging photodetector with a gas electron multiplier. The digital imaging photodetector comprises a gas electron multiplier detector. The gas electron multiplier detector includes a photoelectric converter for converting incident light into photoelectrons or Compton electrons; a gas electron multiplier (GEM) for receiving the photoelectrons or Compton electrons from the photoelectric converter and multiplying them; and a readout unit for receiving an electrical signal indicating a position where an electron cloud multiplied in the gas electron multiplier arrives on an anode, recognizing coordinates of the electron cloud based on the received signal, and outputting the coordinates of the electron cloud.
    Type: Application
    Filed: November 23, 2006
    Publication date: November 20, 2008
    Inventors: Chang Hie Hahn, Il-Gon Kim, Won-Jeong Kim, Jaehoon Yu
  • Patent number: 7101841
    Abstract: The present invention relates to carbohydrate-specific peptides, which have a strong affinity and preparation method thereof. Particularly, the present invention relates to carbohydrate-specific peptides, which have been developed to have an increased strong affinity to carbohydrates by the multiple combinations of peptides having carbohydrates-specific amino acid sequences and preparation method thereof. Carbohydrate-specific peptides of the present invention have a very strong affinity under micromol, so that they can shut off recognition between cells transferred by specific carbohydrates, which means they can be used for the treatment of diseases mediated by recognition between cells and used as a diagnostic kit which diagnoses diseases by confirming the existence of any specific carbohydrate.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: September 5, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Jaehoon Yu, Miyun Kwon, Sunjoo Jeong
  • Patent number: 7022839
    Abstract: The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol, of formula 1, their preparation and their use. Because of their heterodmieric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, they can be effectively used as an antiviral agent, an antibacterial agent or an anticancer drugs.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: April 4, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Jaehoon Yu, Jongkook Lee, Miyun Kwon, Kye-Jung Shin
  • Patent number: 7005539
    Abstract: The present invention relates to ferulic acid dimers and their pharmaceutically acceptable salts, preparation method and use thereof for treating dementia, which have excellent effect on the learning and memory-retention ability in vivo, thus it can be use for dementia.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: February 28, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Jaehoon Yu, Kye-Jung Shin, Dong-Jin Kim, Kyung-Sik Lee
  • Publication number: 20050222055
    Abstract: The present invention relates to novel oxazolidinone derivatives represented as following compound I and a process for the preparation thereof. The compounds of the present invention have wide antibacterial spectrums superior antibacterial activity and low toxicity. Therefore, it can be expected to use as novel antibacterial agent. wherein, R1 is alkylcarboxyl group or —CH2R2 (wherein, R2 is OH, argido group, —OR3 (wherein, R3 is C1-4 alkyl, methansulfonyl, p-toluensulfonyl, carboxyl, C1-4 alkylcarboxyl, C1-4 alkylcarbonyl, benzyloxycarbonyl, or imidazolylcarbonyl), or —NHR4).
    Type: Application
    Filed: July 4, 2002
    Publication date: October 6, 2005
    Inventors: Jaehoon Yu, Jongkook Lee, Miyun Kwon, Ae Pae, Hun Koh
  • Publication number: 20050203180
    Abstract: The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewer side-effects by showing no hormone properties, even when administered for a long period of time, and thus which can be used for neurodegenerative disease including dementia.
    Type: Application
    Filed: June 25, 2002
    Publication date: September 15, 2005
    Applicant: Korea Institute Of Science And Technology
    Inventors: Dong-Jin Kim, Kye-Jung Shin, Jaehoon Yu, Hee-Sul Lee
  • Publication number: 20050009765
    Abstract: The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol of formula 1, their preparation and their use. Because of their heterodimeric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, the can be effectively used as an antiviral agent, an antibacterial agent or an anti cancer drugs.
    Type: Application
    Filed: December 5, 2001
    Publication date: January 13, 2005
    Inventors: Jaehoon Yu, Jongkook Lee, Miyun Kwon, Kye-Jung Shin