Abstract: Antibody-mediated rejection (ABMR) is one of the main obstacles to successful transplantation, including ABO blood group-incompatible (ABOi) transplantation. C4d deposition is a marker of ABMR and is also found in most ABOi allograft tissues. Described herein are anti-C4d CAR Tregs that suppress ABMR in ABOi allografts. Anti-C4d CAR Tregs prepared by retroviral transduction of CAR into CD62L +CD4 +CD25 +Tregs, expressed Foxp3, CD25, CTLA-4, LAP, and GITR to similar extents as non-transduced Tregs. Anti-C4d CAR Tregs were activated by specific binding to C4d and suppressed in vitro T cell proliferation as well as non-transduced Tregs. Furthermore, adoptive transfer of anti-C4d CAR Tregs significantly prolonged mouse ABOi heart allograft survival (P<0.05).

Abstract: Provided are a wireless power transmission device and an operating method therefor, the device confirming an optimum phase adjustment degree for each antenna by applying a reference signal to at least one from among a plurality of patch antennas and sequentially applying a plurality of phase electric signals to each of the remaining antennas, when an RF wave is formed using electric signals from a plurality of power sources.

Abstract: An electric device and its control method are disclosed. The electric device includes: a display unit; a receiving unit configured to receive paper; a sensing unit configured to detect at least one of a state of the received paper and a state of user's handwriting input to the received paper; and a controller configured to display a result value calculated based on the detection of the sensing unit on the display unit. A state of paper or a state of handwriting input to the paper is detected and a corresponding result value is displayed on the display unit, thus improving emotional quality of the electric device.

Abstract: The invention provides an isolated tissue specific glucose responsive promoter having a polymerase binding domain 3? to at least one tripartite transcription factor binding cis element having a hepatocyte nuclear factor-1 (HNF-1) element, a CAAT/enhancer binding protein (C/EBP) response element and a glucose-response element (GRE). The promoter can include a second or third tripartite transcription factor binding cis element. A host cell including the tissue specific glucose responsive promoter of the invention also are provided. Further provided is a method of treating or preventing diabetes.