Patents by Inventor Jagabandhu Das

Jagabandhu Das has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20110160207
    Abstract: A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.
    Type: Application
    Filed: March 2, 2011
    Publication date: June 30, 2011
    Inventors: Stephen T. Wrobleski, Jagabandhu Das, T.G. Murali Dhar, Alaric J. Dyckman, John Hynes, Katerina Leftheris, James Lin, Shuqun Lin
  • Heterocyclic amide compounds useful as kinase inhibitors
    Patent number: 7935696
    Abstract: A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: May 3, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Stephen T. Wrobleski, Jagabandhu Das, T. G. Murali Dhar, Alaric J. Dyckman, John Hynes, Katerina Leftheris, James Lin, Shuqun Lin
  • 1,6-DIHYDRO-1,3,5,6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
    Publication number: 20100210629
    Abstract: The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 19, 2010
    Inventors: William J. Pitts, James Kempson, Junqing Guo, Jagabandhu Das, Charles M. Langevine, Steven H. Spergel, Scott Hunter Watterson
  • 1,6-dihydro-1,3,5,6-tetraaza--indacene based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7737279
    Abstract: The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: June 15, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: William J. Pitts, James Kempson, Junqing Guo, Jagabandhu Das, Charles M. Langevine, Steven H. Spergel, Scott Hunter Watterson
  • 1-imidazo[4,5-]thieno[3,2-]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7683171
    Abstract: The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5, R6 and R7 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: March 23, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: William J. Pitts, Jagabandhu Das, Yuping Qiu, Steven H. Spergel
  • ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20100016320
    Abstract: The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or —C(?O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.
    Type: Application
    Filed: September 18, 2009
    Publication date: January 21, 2010
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Rulin Zhao, Bang-Chi Chen, Stephen T. Wrobleski
  • Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
    Patent number: 7642257
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: January 5, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, John Hynes, Katerina Leftheris, Shuqun Lin, Stephen T. Wrobleski, Hong Wu
  • Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
    Patent number: 7605273
    Abstract: The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or —C(?O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: October 20, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Rulin Zhao, Bang-Chi Chen, Stephen T. Wrobleski
  • Pyrazole-amine compounds useful as kinase inhibitors
    Patent number: 7592338
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: September 22, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert V. Moquin, Stephen T. Wrobleski
  • 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7557211
    Abstract: The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: July 7, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, James Kempson, William J. Pitts, Steven H. Spergel
  • ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080275092
    Abstract: The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or —C(?O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.
    Type: Application
    Filed: May 12, 2008
    Publication date: November 6, 2008
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Rulin Zhao, Bank-Chi Chen, Stephen T. Wrobleski
  • Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
    Patent number: 7419978
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: September 2, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, John Hynes, Katerina Leftheris, Shuqun Lin, Stephen T. Wrobleski, Hong Wu
  • Pyrazole-amide compounds useful as kinase inhibitors
    Patent number: 7414056
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: August 19, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert V. Moquin, Stephen T. Wrobleski
  • HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080171741
    Abstract: A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.
    Type: Application
    Filed: October 25, 2007
    Publication date: July 17, 2008
    Inventors: Stephen T. Wrobleski, Jagabandhu Das, T.G. Murali Dhar, Alaric J. Dyckman, John Hynes, Katerina Leftheris, James Lin, Shuqun Lin
  • PHENYL-ANILINE SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080167304
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.
    Type: Application
    Filed: March 13, 2008
    Publication date: July 10, 2008
    Inventors: Jagabandhu Das, John Hynes, Katerina Leftheris, Shuqun Lin, Stephen T. Wrobleski, Hong Wu
  • Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
    Patent number: 7396935
    Abstract: The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted pyridyl, ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted C(?O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: July 8, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Rulin Zhao, Bang-Chi Chen, Stephen T. Wrobleski
  • Pyrazole-amine compounds useful as kinase inhibitors
    Patent number: 7390810
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 24, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert V. Moquin, Stephen T. Wrobleski
  • PYRAZOLE-AMINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080108626
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert Moquin, Stephen Wrobleski
  • Thiazolyl-based compounds useful as kinase inhibitors
    Patent number: 7323482
    Abstract: The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z1 m and n are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: January 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Hynes, Hong Wu, Katerina Leftheris, Chunjian Liu, Jagabandhu Das, Robert V. Moquin
  • PYRAZOLE-AMINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080004278
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Application
    Filed: August 2, 2007
    Publication date: January 3, 2008
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert Moquin, Stephen Wrobleski