Patents by Inventor Jagadish Ghosh

Jagadish Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Chk2 inhibitor patient selection
    Publication number: 20080125358
    Abstract: The present invention contemplates a method to identify subjects that either have a tumor, or are at risk for tumor development, that are responsive to various inhibitors of an activated-Chk2 protein. Such Chk2 inhibitors may comprise a benzimidazole core structure, and derivatives thereof. Other Chk2 inhibitors may comprise nucleic acids, such as silencing interference RNA's specific for a Chk2 expression. Other Chk2 inhibitors may comprises proteins, such as antibodies. For example, the present invention contemplates that when a Chk2 inhibitor is administered during, or after, ionizing radiation tumor cell apoptosis is increased.
    Type: Application
    Filed: October 26, 2006
    Publication date: May 29, 2008
    Inventors: Dario Altieri, Takehiko Dohi, Jagadish Ghosh
  • Colorectal cancer therapies
    Publication number: 20060204980
    Abstract: Methods related to the targeted treatment of p53+ colorectal cancer cells, and methods of screening for new anti-tumor agents, are described.
    Type: Application
    Filed: December 21, 2005
    Publication date: September 14, 2006
    Inventors: Dario Altieri, Jagadish Ghosh