Patents by Inventor Jagath Rajapakse

Jagath Rajapakse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High sensitivity temporal focusing widefield multiphoton endoscope capable of deep imaging
    Patent number: 9867525
    Abstract: An imaging system is provided that includes a pulsed light source providing pulsed light and is applicable to both microscopes and endoscopes. One or more optical elements with certain dispersive properties are positioned to receive the pulsed light and apply selective dispersive properties to shift the focal plane according to the user and to produce two photon (2p) wide field uniform illumination and 2p wide field structured illumination for the purpose of improving the optical axial resolution and rejection of background signal. An imaging element receives the signal arising from the 2p wide field uniform illumination and 2p wide field structured illumination and produces a respective 3D resolved image of a sample.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: January 16, 2018
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, NATIONAL UNIVERSITY OF SINGAPORE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Yan Seng Elijah Yew, Heejin Choi, Vijay Raj Singh, Daekeun Kim, Jagath Rajapakse, Hanry Yu, Colin J. R. Sheppard, Peter T. C. So
  • HIGH SENSITIVITY TEMPORAL FOCUSING WIDEFIELD MULTIPHOTON ENDOSCOPE CAPABLE OF DEEP IMAGING
    Publication number: 20140128743
    Abstract: An imaging system is provided that includes a pulsed light source providing pulsed light and is applicable to both microscopes and endoscopes. One or more optical elements with certain dispersive properties are positioned to receive the pulsed light and apply selective dispersive properties to shift the focal plane according to the user and to produce two photon (2p) wide field uniform illumination and 2p wide field structured illumination for the purpose of improving the optical axial resolution and rejection of background signal. An imaging element receives the signal arising from the 2p wide field uniform illumination and 2p wide field structured illumination and produces a respective 3D resolved image of a sample.
    Type: Application
    Filed: April 2, 2012
    Publication date: May 8, 2014
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NANYANG TECHNOLOGICAL UNIVERSITY, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Yan Seng Elijah Yew, Heejin Choi, Vijay Raj Singh, Daekeun Kim, Jagath Rajapakse, Hanry Yu, Colin J.R. Sheppard, Peter T.C. So
  • Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
    Patent number: 6903132
    Abstract: Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: June 7, 2005
    Assignees: Agouron Pharmaceuticals, Inc., Pfizer Inc.
    Inventors: Mark B. Anderson, Lance Christopher Christie, Quyen-Quyen Thuy Do, Jun Feng, Yufeng Hong, Haitao Li, Ved P. Pathak, Ranjan Jagath Rajapakse, Eric T. Sun, Eileen Valenzuela Tompkins
  • Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
    Publication number: 20040014787
    Abstract: Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
    Type: Application
    Filed: June 11, 2003
    Publication date: January 22, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: Mark B. Anderson, Lance Christopher Christie, Quyen-Quyen Thuy Do, Jun Feng, Yufeng Hong, Haitao Li, Ved P. Pathak, Ranjan Jagath Rajapakse, Eric T. Sun, Eileen Valenzuela Tompkins
  • Non-peptide antagonists of GLP-1 receptor and methods of use
    Patent number: 6469021
    Abstract: Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding to the GLP-1 receptor and/or prevent activation of the receptor by bound GLP-1. The invention further relates to a method of inhibiting the binding of GLP-1 to the GLP-1 receptor and a method of inhibiting the activation of the GLP-1 receptor. Intermediate compounds useful for making non-peptide GLP-1 receptor antagonists are also described.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: October 22, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Larry Kenneth Truesdale, Richard A. Bychowski, Javier Gonzalez, Atsuo Kuki, Ranjan Jagath Rajapakse, Min Teng, Dan Kiel, Daljit S. Dhanoa, Yufeng Hong, Tso-sheng Chou, Anthony L. Ling, Michael David Johnson, Vlad Edward Gregor