Abstract: A method and a system to place secondary content in predetermined slots in a graphical user interface based on a predicted revenue yield is provided. In example embodiments, in response to a request for primary content, a plurality of pieces of secondary content are identified. A graphical user interface (GUI) is identified that has at least one available slot to be populated with secondary content. For each respective piece of secondary content, a revenue yield is calculated based on a position of slots in the GUI. The revenue yields are analyzed according to a combinatorial optimization algorithm. Finally, instructions to place the plurality of the secondary content in the slots are generated.