Patents by Inventor Jagdish Desai

Jagdish Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents
    Publication number: 20060111411
    Abstract: The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
    Type: Application
    Filed: October 26, 2005
    Publication date: May 25, 2006
    Inventors: Alan Cooper, Hugh Zhu, James Wang, Jagdish Desai, Gerald Shipps, Patrick Curran, D. Allen Annis, Huw Nash, Viyyoor Girijavallabhan
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20050059672
    Abstract: Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
    Type: Application
    Filed: August 4, 2004
    Publication date: March 17, 2005
    Inventors: Hugh Zhu, Alan Cooper, Jagdish Desai, James Wang, Dinanath Rane, Ronald Doll, F. Njoroge, Viyyoor Girijavallabhan
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20040122018
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 24, 2004
    Applicant: Schering Corporation
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Farnesyl protein transferase inhibitors
    Patent number: 6740661
    Abstract: Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: May 25, 2004
    Assignee: Schering Corporation
    Inventors: Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Alan K. Mallams, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Adriano Afonso, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang, Jay Weinstein
  • Treatment of malaria with farnesyl protein transferase inhibitors
    Publication number: 20040087592
    Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.
    Type: Application
    Filed: October 21, 2003
    Publication date: May 6, 2004
    Inventors: William T. Windsor, Patricia C. Weber, James J-S. Wang, Corey O. Strickland, F. George Njoroge, Timothy J. Guzi, Viyyoor M. Girijavallabhan, Johan A. Ferreira, Jagdish A. Desai, Alan B. Cooper, Michael Gelb
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20030229099
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: February 27, 2002
    Publication date: December 11, 2003
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Treatment of malaria with farnesyl protein transferase inhibitors
    Publication number: 20030092705
    Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.
    Type: Application
    Filed: January 18, 2002
    Publication date: May 15, 2003
    Applicant: Schering Corporation
    Inventors: William T. Windsor, Patricia C. Weber, James J-S Wang, Corey O. Strickland, F. George Njoroge, Timothy J. Guzi, Viyyoor M. Girijavallabhan, Johan A. Ferreira, Jagdish A. Desai, Alan B. Cooper, Michael Gelb
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20020198216
    Abstract: The present invention discloses novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: August 28, 2001
    Publication date: December 26, 2002
    Inventors: F. George Njoroge, Bancha Vibulbhan, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Hugh Y. Zhu, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Farnesyl protein transferase inhibitors
    Publication number: 20020103207
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: December 20, 2001
    Publication date: August 1, 2002
    Inventors: Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Alan K. Mallams, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Adriano Afonso, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang, Jay Weinstein
  • Farnesyl protein transferase inhibitors
    Patent number: 6372747
    Abstract: Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: April 16, 2002
    Assignee: Schering Corporation
    Inventors: Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6225322
    Abstract: Novel compounds of formula are disclosed. Also disclosed is a method of inhibiting farnesyl protein transferase function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Also disclosed is a method of effecting an anti-allergic response by administering the compounds.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: May 1, 2001
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Jagdish A. Desai, Anil K. Saksena, Viyyoor M. Girijavallabhan, James J-S Wang
  • Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
    Patent number: 5925648
    Abstract: Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 20, 1999
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, James J-S Wang, Raymond G. Lovey, Jagdish A. Desai, Anil K. Saksena, Viyyoor M. Girijavallabhan, Ronald J. Doll
  • Antifungal 2-azolylmethyl-3-difluorobenzyloxy-2,3-dihydrofluoro-benzo(B) thiophens
    Patent number: 4695579
    Abstract: 2-Azolylmethyl-3-difluorobenzyloxy-2,3-dihydro-5- and 6-fluorobenzo[b]thiophen antifungally compounds, especially 2-(1H-imidazolylmethyl-3-(2',6'-difluorobenzyloxy)-2,3-dihydro-5-fluoroben zo[b]thiophene, pharmaceutical compositions containing them and their use in treating fungal infections in animals including humans are disclosed.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: September 22, 1987
    Assignee: Schering Corporation
    Inventors: Dinanath F. Rane, Jagdish A. Desai, Russell E. Pike