Abstract: A removable lid for selectively sealing a storage vessel is provided, the storage vessel including a base and a continuous sidewall. The removable lid comprises a main body having a bottom surface and a top surface. A tab is movably secured to the main body and the tab is selectively movable between a first position and a second position. A gasket is secured to the bottom surface, and a vent is formed in the gasket. The vent includes an aperture extending from an outer gasket side to an inner gasket side and the vent further includes a vent seal. A sealing protrusion is disposed on the tab. The sealing protrusion includes a sealing face disposed on a distal end of the sealing protrusion, wherein when the tab is disposed in the first position, the sealing face contacts the vent seal and forms a seal with the vent seal to retard fluid flow across the gasket.

Abstract: A retractable instrument in accordance with the disclosure advantageously has a simple construction and fewer pieces or sub-assemblies than known retractable instruments. The retractable instrument includes a barrel that encloses a tool holder. The tool holder has an extension, and a tool extending from the distal end of the extension. A valve selectively covers the tool to protect the tool from environmental conditions. A biasing element is disposed between the valve and the tool holder, the biasing element biases the valve away from the tool holder. A movable closure assembly retains the valve on the extension and selectively allows the lid to open and close. The closure assembly includes a closure ring and a retention ring connected by one or more closure arms. The retention ring is disposed on the tool holder and the retention ring is prevented from sliding off of the tool holder by a retention stop.

Abstract: A retractable instrument in accordance with the disclosure advantageously has a simple construction and fewer pieces or sub-assemblies than known retractable instruments. The retractable instrument includes a barrel that encloses a tool holder. The tool holder has an extension, and a tool extending from the distal end of the extension. A valve selectively covers the tool to protect the tool from environmental conditions. A biasing element is disposed between the valve and the tool holder, the biasing element biases the valve away from the tool holder. A movable closure assembly retains the valve on the extension and selectively allows the lid to open and close. The closure assembly includes a closure ring and a retention ring connected by one or more closure arms. The retention ring is disposed on the tool holder and the retention ring is prevented from sliding off of the tool holder by a retention stop.

Abstract: A retractable instrument in accordance with the disclosure advantageously has a simple construction and fewer pieces or sub-assemblies than known retractable instruments. The retractable instrument includes a barrel that encloses a tool holder. The tool holder has an extension, and a tool extending from the distal end of the extension. A valve selectively covers the tool to protect the tool from environmental conditions. A biasing element is disposed between the valve and the tool holder, the biasing element biases the valve away from the tool holder. A movable closure assembly retains the valve on the extension and selectively allows the lid to open and close. The closure assembly includes a closure ring and a retention ring connected by one or more closure arms. The retention ring is disposed on the tool holder and the retention ring is prevented from sliding off of the tool holder by a retention stop.

Abstract: A valve includes a first valve portion made from a first material, the first valve portion including a body, a door, and an inner hinge pivotably connecting the body to the door, the body including a first opening at a first end and a second opening at a second end opposite the first end, and a circumferential recess disposed in the second end, wherein the inner hinge pivotably connects the door to the body at the first end and a second valve portion made from a second material, the second valve portion including an inner seal disposed in the circumferential recess, the inner seal including a circumferential ridge extending inwardly, the second valve portion further including a door seal disposed on the first end of the body.

Abstract: A valve includes a first valve portion made from a first material, the first valve portion including a body, a door, and an inner hinge pivotably connecting the body to the door, the body including a first opening at a first end and a second opening at a second end opposite the first end, and a circumferential recess disposed in the second end, wherein the inner hinge pivotably connects the door to the body at the first end and a second valve portion made from a second material, the second valve portion including an inner seal disposed in the circumferential recess, the inner seal including a circumferential ridge extending inwardly, the second valve portion further including a door seal disposed on the first end of the body.

Abstract: A valve includes a first valve portion made from a first material, the first valve portion including a body, a door, and an inner hinge pivotably connecting the body to the door, the body including a first opening at a first end and a second opening at a second end opposite the first end, and a circumferential recess disposed in the second end, wherein the inner hinge pivotably connects the door to the body at the first end and a second valve portion made from a second material, the second valve portion including an inner seal disposed in the circumferential recess, the inner seal including a circumferential ridge extending inwardly, the second valve portion further including a door seal disposed on the first end of the body.

Abstract: A retractable instrument in accordance with the disclosure advantageously has a simple construction and fewer pieces or sub-assemblies than known retractable instruments. The retractable instrument includes a barrel that encloses a tool holder. The tool holder has an extension, and a tool extending from the distal end of the extension. A valve selectively covers the tool to protect the tool from environmental conditions. A biasing element is disposed between the valve and the tool holder, the biasing element biases the valve away from the tool holder. A movable closure assembly retains the valve on the extension and selectively allows the lid to open and close. The closure assembly includes a closure ring and a retention ring connected by one or more closure arms. The retention ring is disposed on the tool holder and the retention ring is prevented from sliding off of the tool holder by a retention stop.

Abstract: A writing instrument has a barrel, a flag dispenser partially inserted into the barrel, and a rotating or sliding cover that engages with and covers the flag dispenser. In different positions, the rotating or sliding cover enables various functions of the flag dispenser. For example, the cover may be moved into a position to enable withdrawal of tape flags by a user. The cover may also be configured to move into a position that covers and protects the tape flags. In refillable embodiments of the writing instrument, the cover may also be removed to enable a flip cover portion of the flag dispenser to be opened to provide access to a tape flag chamber.

Abstract: In one embodiment of a writing instrument with a tape flag dispenser, a writing instrument has a body portion, a writing tip, and a flag dispenser that can be attached to and detached from the body portion. The flag dispenser holds a supply of tape flags, such as a folded stack of tape flags, which can be removed through an opening in the dispenser. The flag dispenser can be, for example, a cap that covers the writing tip or an attachment that affixes to an end of the body portion. In another embodiment, a writing instrument has a body portion, a writing tip, a flag dispenser integrally incorporated into the body portion, a containing section housed in the flag dispenser, and an opening in the containing section through which tape flags can be issued.

Abstract: A writing instrument has a barrel, a flag dispenser partially inserted into the barrel, and a rotating or sliding cover that engages with and covers the flag dispenser. In different positions, the rotating or sliding cover enables various functions of the flag dispenser. For example, the cover may be moved into a position to enable withdrawal of tape flags by a user. The cover may also be configured to move into a position that covers and protects the tape flags. In refillable embodiments of the writing instrument, the cover may also be removed to enable a flip cover portion of the flag dispenser to be opened to provide access to a tape flag chamber.

Abstract: A writing instrument has a barrel, a flag dispenser partially inserted into the barrel, and a rotating or sliding cover that engages with and covers the flag dispenser. In different positions, the rotating or sliding cover enables various functions of the flag dispenser. For example, the cover may be moved into a position to enable withdrawal of tape flags by a user. The cover may also be configured to move into a position that covers and protects the tape flags. In refillable embodiments of the writing instrument, the cover may also be configured to move into a position that allows a user to replace or replenish the tape flags.

Abstract: A valve includes a first valve portion made from a first material, the first valve portion including a body, a door, and an inner hinge pivotably connecting the body to the door, the body including a first opening at a first end and a second opening at a second end opposite the first end, and a circumferential recess disposed in the second end, wherein the inner hinge pivotably connects the door to the body at the first end and a second valve portion made from a second material, the second valve portion including an inner seal disposed in the circumferential recess, the inner seal including a circumferential ridge extending inwardly, the second valve portion further including a door seal disposed on the first end of the body.

Abstract: In one embodiment of a writing instrument with a tape flag dispenser, a writing instrument has a body portion, a writing tip, and a flag dispenser that can be attached to and detached from the body portion. The flag dispenser holds a supply of tape flags, such as a folded stack of tape flags, which can be removed through an opening in the dispenser. The flag dispenser can be, for example, a cap that covers the writing tip or an attachment that affixes to an end of the body portion. In another embodiment, a writing instrument has a body portion, a writing tip, a flag dispenser integrally incorporated into the body portion, a containing section housed in the flag dispenser, and an opening in the containing section through which tape flags can be issued.

Abstract: In one embodiment of a writing instrument with a tape flan dispenser, a writing instrument has a body portion, a writing tip, and a flag dispenser chat can be attached to and detached from the body portion. The flag dispenser holds a supply of tape flags, such as a folded stack of tape flags, which can be removed through an opening in the dispenser. The flag dispenser can be, for example, a cap that covers the writing tip or an attachment that affixes to an end of the body portion. In another embodiment, a writing instrument has a body portion, a writing tip, a flag dispenser integrally incorporated into the body portion, a containing section housed in the flag dispenser, and an opening in the containing section through which tape flags can be issued.

Abstract: The invention pertains to bioconjugation systems comprising sterically constrained cis-diols and borates.

Abstract: The invention pertains to bioconjugation systems comprising sterically constrained cis-diols and borates.

Abstract: Disclosed herein are writing instruments with tape flag dispensers. In one of various embodiments, a writing instrument has a barrel, a flag dispenser partially inserted into the barrel, and a rotating cover that engages with and covers the flag dispenser. In another embodiment, a writing instrument includes a barrel, a flag dispenser partially inserted into the barrel, and a sliding cover that engages with and covers the flag dispenser. In different positions, the rotating or sliding cover enables various functions of the flag dispenser. For example, the cover may be moved into a position to enable withdrawal of tape flags by a user. The cover may also be configured to move into a position that covers and protects the tape flags. In refillable embodiments of the writing instrument, the cover may also be configured to move into a position that allows a user to replace or replenish the tape flags.

Abstract: Disclosed herein are writing instruments with tape flag dispensers. In one of the various embodiments, a writing instrument has a body portion, a writing tip, and a flag dispenser that can be attached to and detached from the body portion. The flag dispenser holds a supply of tape flags, such as a folded stack of tape flags, which can be removed through an opening in the dispenser. The flag dispenser can be, for example, a cap that covers the writing tip or an attachment that affixes to an end of the body portion. In another embodiment, a writing instrument has a body portion, a writing tip, a flag dispenser integrally incorporated into the body portion, a containing section housed in the flag dispenser, and an opening in the containing section through which tape flags can be issued.