Patents by Inventor Jaime Camilo TENEB LOBOS

Jaime Camilo TENEB LOBOS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Promoter with an enriched Cytosine-Guanine dinucleotide region, vectors, cellular lines, method for producing recombinant protein
    Patent number: 11618904
    Abstract: The present invention relates to the field of genetic engineering, preferably the expression of recombinant proteins (RP). In particular, the invention relates to a promoter and variants thereof having an equal function and more than 90% sequence identity. The promoter comprises a fragment of 1147 base pairs (bp) of a first promoter, promoter of the ?-actin gene of the Cricetulus griseus genome, enriched in cytosine-guanine dinucleotides (RegCG). The first promoter can be upstream of a second promoter, cytomegalovirus (CMV) promoter. The invention also relates to vectors, transfected cellular lines and a method for producing RP in mammal cells that have been transfected with vectors containing said promoter or variants thereof.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: April 4, 2023
    Assignees: UNIVERSIDAD DE CHILE, BPH S.A., INGENERIA ORBICORP LTDA
    Inventors: Juan Carlos Aguillon Gutierrez, Maria Carmen Molina Sampayo, Roberto Aquiles Zuñiga Olate, Matias Fernando Guitierrez Gonzalez, Norberto Andres Collazo Muñoz, Jaime Camilo Teneb Lobos
  • Human antibody and fragments thereof for use in the treatment of gastric cancer (GC) and other types of tumours expressing the MICA protein (MHC class I chain-related protein A gene)
    Patent number: 11518811
    Abstract: A bivalent, anti-MICA human monoclonal antibody formed by two or more heavy and light chains with a variable immunoglobulin domain neutralises the MICA protein in its soluble state and opsonises tumour cells expressing the antigen, stimulating adaptive immunity in the treatment of gastric cancer or other types of cancer in which the tumour cells express MICA in the soluble form or abundantly on their surface.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: December 6, 2022
    Inventors: María Carmen Molina Sampayo, Juan Carlos Aguillón Gutierrez, Carolina Hager Ribeiro, Roberto Aquiles Zúñiga Olate, Norberto Andrés Collazomuñoz, Lorenzo Leiva Araya, Matías Fernando Gutierrez Gonzalez, Jaime Camilo Teneb Lobos, Alfonso Enrique Romero Trujillo, Bastían Nicolás Jerez Donoso
  • HUMAN ANTIBODY AND FRAGMENTS THEREOF FOR USE IN THE TREATMENT OF GASTRIC CANCER (GC) AND OTHER TYPES OF TUMOURS EXPRESSING THE MICA PROTEIN (MHC CLASS I CHAIN-RELATED PROTEIN A GENE)
    Publication number: 20210139593
    Abstract: A bivalent, anti-MICA human monoclonal antibody formed by two or more heavy and light chains with a variable immunoglobulin domain neutralises the MICA protein in its soluble state and opsonises tumour cells expressing the antigen, stimulating adaptive immunity in the treatment of gastric cancer or other types of cancer in which the tumour cells express MICA in the soluble form or abundantly on their surface.
    Type: Application
    Filed: December 27, 2018
    Publication date: May 13, 2021
    Inventors: María Carmen MOLINA SAMPAYO, Juan Carlos AGUILLÓN GUTIERREZ, Carolina HAGER RIBEIRO, Roberto Aquiles ZÚÑIGA OLATE, Norberto Andrés COLLAZOMUÑOZ, Lorenzo LEIVA ARAYA, Matías Fernando GUTIERREZ GONZALEZ, Jaime Camilo TENEB LOBOS, Alfonso Enrique ROMERO TRUJILLO, Bastián Nicolás JEREZ DONOSO
  • PROMOTER WITH AN ENRICHED CYTOSINE-GUANINE DINUCLEOTIDE REGION, VECTORS, CELLULAR LINES, METHOD FOR PRODUCING RECOMBINANT PROTEIN
    Publication number: 20190309323
    Abstract: The present invention relates to the field of genetic engineering, preferably the expression of recombinant proteins (RP). In particular, the invention relates to a promoter and variants thereof having an equal function and more than 90% sequence identity. The promoter comprises a fragment of 1147 base pairs (bp) of a first promoter, promoter of the ?-actin gene of the Cricetulus griseus genome, enriched in cytosine-guanine dinucleotides (RegCG). The first promoter can be upstream of a second promoter, cytomegalovirus (CMV) promoter. The invention also relates to vectors, transfected cellular lines and a method for producing RP in mammal cells that have been transfected with vectors containing said promoter or variants thereof.
    Type: Application
    Filed: June 9, 2017
    Publication date: October 10, 2019
    Inventors: Juan Carlos AGUILLON GUTIERREZ, Maria Carmen MOLINA SAMPAYO, Roberto Aquiles ZUÑIGA OLATE, Matias Fernando GUITIERREZ GONZALEZ, Norberto Andres COLLAZO MUÑOZ, Jaime Camilo TENEB LOBOS