Patents by Inventor Jaime Juan Benitez-Marzan

Jaime Juan Benitez-Marzan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOADING NUCLEIC ACIDS ONTO SUBSTRATES
    Publication number: 20230405544
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Application
    Filed: March 22, 2023
    Publication date: December 21, 2023
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula, Michael W. Hunkapiller, Erik Miller, Satwik Kamtekar
  • Loading nucleic acids onto substrates
    Patent number: 11642643
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 9, 2023
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
  • METHODS AND COMPOSITIONS FOR DELIVERY OF MOLECULES AND COMPLEXES TO REACTION SITES
    Publication number: 20220364168
    Abstract: The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in loading of polymerase enzyme complexes into a predetermined number of reaction sites, including nanoscale wells.
    Type: Application
    Filed: April 12, 2022
    Publication date: November 17, 2022
    Inventors: Jaime Juan Benitez-Marzan, Natasha Popovich, Lei Sun, Satwik Kamtekar, Keith Bjornson, Jeremiah Hanes, Karl Voss, Erik Miller, Thomas Linsky, Leewin Chern
  • Methods and compositions for delivery of molecules and complexes to reaction sites
    Patent number: 11332787
    Abstract: The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in loading of polymerase enzyme complexes into a predetermined number of reaction sites, including nanoscale wells.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 17, 2022
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jaime Juan Benitez-Marzan, Natasha Popovich, Lei Sun
  • NUCLEIC ACID SEQUENCING CARTRIDGES, PACKAGED DEVICES, AND SYSTEMS
    Publication number: 20210215607
    Abstract: Provided herein are cartridges, packaged devices, and systems for improved nucleic acid sequencing. The cartridges, devices, and systems include a highly multiplexed optical chip comprising a plurality of nanoscale reaction regions that is configured to perform and report nucleic acid sequencing reactions. The chips are, in some embodiments, packaged for use in analytical nucleic acid sequencing reactions. The chips may be attached to a printed circuit board, may be surrounded by a protective enclosure, may include a flow cell, and may include optical features to minimize or block photobleaching of the sequencing reagents and background fluorescent signals. Also provided are analytical systems for nucleic acid sequencing that comprise the disclosed cartridges and packaged devices.
    Type: Application
    Filed: January 14, 2021
    Publication date: July 15, 2021
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Russell BERMAN, Jaime Juan BENITEZ-MARZAN, Natasha POPOVICH, Aaron RULISON, Ravi SAXENA
  • LOADING NUCLEIC ACIDS ONTO SUBSTRATES
    Publication number: 20210069664
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 11, 2021
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
  • Loading nucleic acids onto substrates
    Patent number: 10814299
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: October 27, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
  • METHODS AND COMPOSITIONS FOR DELIVERY OF MOLECULES AND COMPLEXES TO REACTION SITES
    Publication number: 20200002765
    Abstract: The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in loading of polymerase enzyme complexes into a predetermined number of reaction sites, including nanoscale wells.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 2, 2020
    Inventors: Jaime Juan Benitez-Marzan, Natasha Popovich, Lei Sun, Satwik Kamtekar, Keith Bjornson, Jeremiah Hanes, Karl Voss, Erik Miller, Thomas Linsky, Leewin Chern
  • LOADING NUCLEIC ACIDS ONTO SUBSTRATES
    Publication number: 20170136433
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Application
    Filed: November 17, 2016
    Publication date: May 18, 2017
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula, Yufeng Qian