Patents by Inventor Jaime Masferrer

Jaime Masferrer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer
    Patent number: 7320996
    Abstract: The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitors of the formula I: wherein R1, R2, R3, R4, R5, R6, and R7 are defined herein, in combination with cyclooxygenase inhibitors, in particular cyclooxygenase-2 selective inhibitors.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: January 22, 2008
    Assignees: Sugen, Inc, Pharmacia Corporation
    Inventors: Jaime Masferrer, Parul Doshi, Julie Cherrington
  • Methods using a combination of 3-heteroaryl-2-indolinone and a cyclooxygenase-2 inhibitor for the treatment of neoplasia
    Publication number: 20060252766
    Abstract: The present invention provides methods and compositions useful for treatment or prevention of neoplasia by administering a combination comprising a 3-heteroaryl-2-indolinone compound and a COX-2 selective inhibitor. Further provided are compositions, pharmaceutical compositions, and kits for treatment and prevention of neoplasia.
    Type: Application
    Filed: May 15, 2003
    Publication date: November 9, 2006
    Inventors: Jaime Masferrer, Julie Cherrington, Kathleen Leahy, Ben Zweifel
  • Method of using a cox-2 inhibitor and a topoisomerase II inhibitor as a combination therapy in the treatment of neoplasia
    Publication number: 20060105961
    Abstract: The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia or a neoplasia-related disorder in a mammal using a combination of a COX-2 inhibitor and a topoisomerase II inhibitor.
    Type: Application
    Filed: December 17, 2003
    Publication date: May 18, 2006
    Applicant: Pharmacia Corporation
    Inventor: Jaime Masferrer
  • Combination therapy comprising a Cox-2 inhibitor and an antineoplastic agent
    Publication number: 20050227929
    Abstract: A method for treating or preventing neoplasia or a neoplasia-related disorder in a subject is provided, the method comprising administering to the subject an effective amount of a combination comprising a Cox-2 inhibitor and an antineoplastic agent.
    Type: Application
    Filed: November 15, 2004
    Publication date: October 13, 2005
    Inventor: Jaime Masferrer
  • Combination of a Cox-2 inhibitor and a DNA topoisomerase I inhibitor for treatment of neoplasia
    Publication number: 20050187172
    Abstract: The present invention provides combinations of a Cox-2 inhibitor and a DNA topoisomerase inhibitor and methods of use thereof for preventing and/or treating neoplasia or or a neoplasia-related disorder in a subject.
    Type: Application
    Filed: December 23, 2004
    Publication date: August 25, 2005
    Inventor: Jaime Masferrer
  • Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of neoplasia
    Publication number: 20050085477
    Abstract: The present invention provides compositions and methods for the treatment of neoplasia in a subject. More particularly, the invention provides a combination therapy for the treatment of a neoplasia comprising the administration to a subject of a serotonin modulating agent in combination with a cyclooxygenase-2 selective inhibitor.
    Type: Application
    Filed: August 20, 2004
    Publication date: April 21, 2005
    Inventor: Jaime Masferrer
  • Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent
    Publication number: 20050058725
    Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent.
    Type: Application
    Filed: September 20, 2004
    Publication date: March 17, 2005
    Inventors: John McKearn, Gary Gordon, James Cunningham, Stephen Gately, Alane Koki, Jaime Masferrer
  • Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent
    Publication number: 20050037090
    Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a cyclooxygenase-2 inhibitor and an antineoplastic agent.
    Type: Application
    Filed: September 20, 2004
    Publication date: February 17, 2005
    Inventors: John McKearn, Gary Gordon, James Cunningham, Stephen Gately, Alane Koki, Jaime Masferrer
  • Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist
    Publication number: 20040127470
    Abstract: The present invention relates to a novel method of preventing and/or treating neoplasia disorders in a subject that is in need of such prevention or treatment by administering to the subject at least one Cox-2 inhibitor in combination with an EGF receptor antagonist. Compositions, pharmaceutical compositions and kits are also described.
    Type: Application
    Filed: August 29, 2003
    Publication date: July 1, 2004
    Applicant: Pharmacia Corporation
    Inventor: Jaime Masferrer
  • Uroguanylin and cyclooxygenase-2 inhibitor combinations for inhibition of intestinal cancer
    Publication number: 20040121961
    Abstract: Disclosed is a method of retarding the development of polyps and prevention, inhibition and treatment of cancer in the intestine of a subject by administration of a composition comprising a peptide with the active domain of uroguanylin or any agonist peptide or compound binding to the guanylate cyclase receptor GC-C in the intestine in combination with a naturally occurring, derived from a naturally occurring, or a chemically synthesized cycloogenase-2 inhibitor, preferably a selective cyclooxygenase-2 inhibitor.
    Type: Application
    Filed: January 21, 2004
    Publication date: June 24, 2004
    Inventor: Jaime Masferrer
  • Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
    Publication number: 20030220384
    Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula I.
    Type: Application
    Filed: August 23, 2002
    Publication date: November 27, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Karen Seibert, Jaime Masferrer, Gary B. Gordon
  • Combination therapy for the treatment of cancer
    Publication number: 20030216410
    Abstract: The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitors in combination with cyclooxygenase inhibitors, in particular cyclooxygenase-2 selective inhibitors.
    Type: Application
    Filed: August 15, 2002
    Publication date: November 20, 2003
    Applicant: Pharmacia Corporation
    Inventors: Jaime Masferrer, Parul Doshi, Julie Cherrington
  • Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
    Patent number: 6469040
    Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula I. wherein A, R2 and R3 are as described in the specification.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: October 22, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Karen Seibert, Jaime Masferrer, Gary B Gordon
  • Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
    Patent number: 6025353
    Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating angiogenic disorders.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: February 15, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Jaime Masferrer, Amiram Raz
  • Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
    Patent number: 5972986
    Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula I. ##STR1## wherein A, R.sup.2 and R.sup.3 are as described in the specification.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: October 26, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Karen Seibert, Jaime Masferrer, Gary B Gordon