Abstract: The present invention relates to methods for treating metastatic triple negative breast cancer in a human patient which has been identified as having a PD-L1 enriched tumor comprising administering, as monotherapy, an anti-PD-1 antibody or antigen binding fragment thereof (e.g., pembrolizumab) in specific amounts to the patient about every three or six weeks, wherein the PD-L1 enriched tumor is a tumor identified as having a CPS score of ?10.

Abstract: The floatable umbrella with self-ballasting member includes an umbrella that is selectively attached to an umbrella float. An umbrella weight is selectively attached to a distal end of the umbrella so as to form a ballasting capability for the umbrella when said umbrella is partially submerged within a body of water. A tether is selectively attached to the umbrella float. The tether includes a wristband on a distal end, which is adapted to engage a wrist of an end user. The tether may optionally include a tether float as well as a magnet release that separates between the tether float and the wristband.