Patents by Inventor Jaime Tomas Navarro

Jaime Tomas Navarro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
    Patent number: 6617457
    Abstract: The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: September 9, 2003
    Assignee: Esteve Quimica, S.A.
    Inventors: Montserrat Monsalvatje Llagostera, Marti Bartra Sanmarti, Jaime Tomas Navarro, Salvador Puig Torres
  • Polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it
    Patent number: 5872125
    Abstract: It comprises the new polymorphs I and II of Lesopitron dihydrochloride, characterized by their infrared spectra and their X-ray diffraction patterns. They are obtained by crystallization of Lesopitron dihydrochloride. It also comprises the forms I-hydrate and II-hydrate, which are obtained from the corresponding polymorphs, which have a water content from 3 to 6% and from 1.5 to 2.5%, respectively. These products are used in human medicine mainly due to their pharmacological activity over the central nervous system.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: February 16, 1999
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Pilar Lupon-Roses, Jaime Tomas-Navarro, Salvador Puig-Torres, Jordi Frigola-Constansa