Patents by Inventor Jake REDER

Jake REDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTORS TARGETING TIM-1
    Publication number: 20230355673
    Abstract: The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
    Type: Application
    Filed: December 12, 2022
    Publication date: November 9, 2023
    Inventors: Terrance A. STADHEIM, Joana M. MURAD, Jake REDER, Henry C. MARSH, Li-Zhen HE, Tibor KELER
  • Chimeric antigen receptors targeting TIM-1
    Patent number: 11541076
    Abstract: The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: January 3, 2023
    Assignees: CELDARA MEDICAL, LLC, CELLDEX THERAPEUTICS, INC.
    Inventors: Terrance A. Stadheim, Joana M. Murad, Jake Reder, Henry C. Marsh, Jr., Li-Zhen He, Tibor Keler
  • CELLULAR BASED THERAPIES TARGETING DISEASE-ASSOCIATED MOLECULAR MEDIATORS OF FIBROTIC, INFLAMMATORY AND AUTOIMMUNE CONDITIONS
    Publication number: 20200369773
    Abstract: The invention provides chimeric antigen receptors (CARs), nucleic acid sequences encoding a CAR, vectors comprising a nucleic acid sequence encoding a CAR, cells expressing a CAR, pharmaceutical compositions comprising a cell expressing a CAR, wherein the CAR binds to a target molecule expressed on disease-associated macrophages or over- or aberrantly-expressed in fibrosis. The invention further provides vectors encoding a CAR and a fibrotic disease-modulatory molecule (FDMM), and cells expressing both a CAR and an FDMM. The invention also provides methods of treating a subject using a CAR, a nucleic acid sequence, a vector or vectors, or a CAR-expressing cell, a cell expressing both a CAR and an FDMM, or a pharmaceutical composition, and to methods of generating a CAR-expressing cell or a cell expressing both a CAR and an FDMM.
    Type: Application
    Filed: August 20, 2018
    Publication date: November 26, 2020
    Inventors: Michael Whitfield, Patricia Pioli, Charles Sentman, Jake Reder, Joana Murad, Yolanda Nesbeth
  • CHIMERIC ANTIGEN RECEPTORS TARGETING TIM-1
    Publication number: 20190336534
    Abstract: The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
    Type: Application
    Filed: January 12, 2018
    Publication date: November 7, 2019
    Inventors: Terrance A. STADHEIM, Joana M. MURAD, Jake REDER, Henry C. MARSH, JR., Li-Zhen HE, Tibor KELER