Patents by Inventor Jakob Busch-Petersen

Jakob Busch-Petersen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CATHEPSIN C INHIBITORS
    Publication number: 20120142668
    Abstract: Disclosed are 4-amino-2-butenamides of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease.
    Type: Application
    Filed: August 11, 2010
    Publication date: June 7, 2012
    Inventors: Niall Anderson, Ann M. Bullion, Neysa Nevins, Michael R. Palovich, Steven L. Sollis, Michael D. Wall, Jakob Busch-Petersen, Brian Evans, Huijie Li
  • INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
    Publication number: 20120040958
    Abstract: The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 16, 2012
    Inventors: Jeffrey Charles Boehm, Jakob Busch-Petersen, Wei Fu, Qi Jin, Jeffrey K. Kerns, Huijie Li, Guoliang Lin, Xichen Lin, Christopher E. Neipp
  • IL-8 receptor antagonists
    Patent number: 8097626
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (Il-8).
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: January 17, 2012
    Assignee: GlaxoSmithKline LLC
    Inventor: Jakob Busch-Petersen
  • Indole carboxamides as IKK2 inhibitors
    Patent number: 8071584
    Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: December 6, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Charles Boehm, Jakob Busch-Petersen, Wei Fu, Qi Jin, Jeffrey K. Kerns, Huijie Li, Guoliang Lin, Xichen Lin, Christopher E. Neipp
  • IL-8 receptor antagonists
    Patent number: 8044075
    Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 25, 2011
    Assignee: GlaxoSmithKline
    Inventors: Gregory L. Adams, James A. Brackley, III, Jakob Busch-Petersen, Jianghe Deng, Wei Fu, Huijie Li, Jack J. Taggart, Feng Wang, Yonghui Wang, Katherine Louisa Widdowson, Hongyi Yu
  • IL-8 RECEPTOR ANTAGONISTS
    Publication number: 20110105563
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: January 12, 2011
    Publication date: May 5, 2011
    Inventor: Jakob BUSCH-PETERSEN
  • IL-8 RECEPTOR ANTAGONISTS
    Publication number: 20110059937
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Inventor: Jakob Busch-Petersen
  • IL-8 receptor antagonists
    Patent number: 7893089
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: February 22, 2011
    Assignee: GlaxoSmithKline, LLC
    Inventor: Jakob Busch-Petersen
  • IL-8 Receptor Antagonists
    Publication number: 20100298387
    Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: December 5, 2007
    Publication date: November 25, 2010
    Inventors: Gregory L. Adams, James A. Brackley, III, Jakob Busch-Petersen, Jianghe Deng, Wei Fu, Huijie Li, Jack J. Taggart, Feng Wang, Yonghui Wang, Katherine Louisa Widdowson, Hongyi Yi
  • METHOD OF TREATMENT
    Publication number: 20100256157
    Abstract: This invention relates to the use of a sulfonamide substituted diphenyl urea compound to treat cystic fibrosis, or the symptoms associated with cystic fibrosis.
    Type: Application
    Filed: March 19, 2010
    Publication date: October 7, 2010
    Inventors: Jakob Busch-Petersen, Thomas B. LEONARD, Michael R. Palovich, Henry M. Sarau, Aili L. Lazaar, Katherine L. Widdowson
  • INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
    Publication number: 20100130468
    Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: March 20, 2008
    Publication date: May 27, 2010
    Inventors: Jeffrey Charles Boehm, Jakob Busch-Petersen, Wei Fu, Qi Jin, Jeffrey K. Kerns, Huijie Li, Guoliang Lin, Xichen Lin, Christopher E. Neipp
  • IL-8 receptor antagonists
    Patent number: 7709485
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: May 4, 2010
    Assignee: GlaxoSmithkline LLC
    Inventors: Jakob Busch-Petersen, Michael R Palovich, Katherine L. Widdowson
  • IL-8 Receptor Antagonists
    Publication number: 20090298810
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (II-8).
    Type: Application
    Filed: April 20, 2007
    Publication date: December 3, 2009
    Inventor: Jakob Busch-Petersen
  • Method of Treatment
    Publication number: 20090281110
    Abstract: This invention relates to the use of sulfonamide substituted diphenyl urea compounds to treat endometriosis.
    Type: Application
    Filed: June 22, 2007
    Publication date: November 12, 2009
    Inventors: Jakob Busch-Petersen, Jeffery D. Bray, Nicholas J. Laping, Eugene T. Grygielko, Richard M. Goodman
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20090258858
    Abstract: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
    Type: Application
    Filed: October 28, 2005
    Publication date: October 15, 2009
    Inventors: Jakob Busch-Petersen, Jeffrey Charles Boehm, Huijie Li, John J. Taggart, Hong Xing Yan
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 7579361
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: August 25, 2009
    Assignee: Glaxo Group Limited
    Inventors: Jakob Busch-Petersen, Michael R. Palovich, Zehong Wan, Hongxing Yan, Chongjie Zhu
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 7579345
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: August 25, 2009
    Assignee: Glaxo Group Limited
    Inventors: Jakob Busch-Petersen, Christopher E. Neipp, Michael R. Palovich
  • Muscarinic acetylcholine receptor antagonists
    Patent number: 7576096
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: August 18, 2009
    Assignee: Glaxo Group Limited
    Inventors: Jakob Busch-Petersen, Michael R. Palovich, Zehong Wan, Hongxing Yan, Chongjie Zhu
  • IL-8 Receptor Antagonists
    Publication number: 20090170871
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: June 22, 2007
    Publication date: July 2, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jakob Busch-Petersen, Christopher S. Brook, Richard M. Goodman, Edward C. Webb
  • IL-8 RECEPTOR ANTAGONISTS
    Publication number: 20090093492
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: October 9, 2007
    Publication date: April 9, 2009
    Inventors: Jakob Busch-Petersen, Michael R. Palovich, Katherine L. Widdowson