Abstract: An ampule, a method of manufacturing the same and apparatus for the performance of such method is disclosed. The ampule comprises a hollow compartment for receiving medicaments or drugs which can be dispensed by means of a syringe. The wall bounding the hollow compartment is formed of a carrier layer composed of aluminum foil free of pores and having an inner layer formed of a heat sealable material which can be sterilized and does not react with the filled material. At the outside of the carrier layer there is provided a marked penetration or puncture location at which there can be pierced the wall by means of the needle of the syringe without damaging such needle.