Patents by Inventor Jakob Felding

Jakob Felding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 11702652
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: July 18, 2023
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation
    Patent number: 11292788
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: April 5, 2022
    Assignee: Immunic AG
    Inventors: Jakob Felding, Hella Kohlhof, Manfred Groppel, Rolf Andreas Muhler, Daniel Vitt, Carine Chevrier, Mirko Zaja, Stefan Tasler
  • Method for the synthesis of a bifunctional complex
    Patent number: 11001835
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: May 11, 2021
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation
    Publication number: 20210061796
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 4, 2021
    Applicant: Immunic AG
    Inventors: Jakob FELDING, Hella KOHLHOF, Manfred GROPPEL, Rolf Andreas MUHLER, Daniel VITT, Carine CHEVRIER, Mirko ZAJA, Stefan TASLER
  • Method for synthesising templated molecules
    Patent number: 10731151
    Abstract: The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: August 4, 2020
    Assignee: NUEVOLUTION A/S
    Inventors: Henrik Pedersen, Anette Holtmann, Thomas Franch, Alex Haahr Gouliaev, Jakob Felding
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20200216836
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: January 15, 2020
    Publication date: July 9, 2020
    Applicant: NUEVOLUTION A/S
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JAKOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PETERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex Haahr GOULIAEV, Henrik PEDERSEN
  • Templated molecules and methods for using such molecules
    Patent number: 10669538
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: June 2, 2020
    Assignee: NUEVOLUTION A/S
    Inventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20190330618
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: January 22, 2019
    Publication date: October 31, 2019
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JAKOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PETERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex GOULIAEV, Henrik PEDERSEN
  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 10287576
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 14, 2019
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX
    Publication number: 20190136227
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Application
    Filed: August 7, 2018
    Publication date: May 9, 2019
    Inventors: Per-Ola FRESKGARD, Thomas FRANCH, Alex Haahr GOULIAEV, Mikkel Dybro LUNDORF, Jakob FELDING, Eva Kampmann OLSEN, Anette HOLTMANN, Soeren Nyboe JAKOBSEN, Christian Klarner SAMS, Sanne Schroeder GLAD, Kim Birkebaek JENSEN, Henrik PEDERSEN
  • Method for the synthesis of a bifunctional complex
    Patent number: 10077440
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: September 18, 2018
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
    Publication number: 20170247688
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Application
    Filed: December 12, 2016
    Publication date: August 31, 2017
    Applicant: NUEVOLUTION A/S
    Inventors: Thomas FRANCH, Mikkel Dybro LUNDORF, Søren Nyboe JACOBSEN, Eva Kampmann OLSEN, Anne Lee ANDERSEN, Anette HOLTMANN, Anders Holm HANSEN, Anders Malling SØRENSEN, Anne GOLDBECH, Daen de LEON, Ditte Kievsmose KALDOR, Frank Abildgaard SLØK, Gitte Nystrup HUSEMOEN, Johannes DOLBERG, Kim Birkebæk JENSEN, Lene PEDERSEN, Mads NØRREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schrøder GLAD, Søren NEVE, Thomas THISTED, Tine Titilola Akinleminu KRONBORG, Christian Klarner SAMS, Jakob FELDING, Per-Ola FRESKGARD, Alex Haahr GOULIAEV, Henrik PEDERSEN
  • TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES
    Publication number: 20170198283
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Application
    Filed: October 13, 2016
    Publication date: July 13, 2017
    Inventors: Henrik PEDERSEN, Alex Haahr GOUILAEV, Thomas FRANCH, Christian Klarner SAMS, Eva Kampmann OLSEN, Frank Abilgaard SLOK, Gitte Nystrup HUSEMOEN, Jakob FELDING, Lene HYLDTOFT, Mads NORREGAARD-MADSEN, Michael Anders GODSKESEN, Sanne Schroder GLAD, Thomas THISTED, Per-Ola FRESKGARD, Anette HOLTMANN
  • Templated molecules and methods for using such molecules
    Patent number: 9688980
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 27, 2017
    Assignee: NUEVOLUTION
    Inventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
  • Enzymatic encoding methods for efficient synthesis of large libraries
    Patent number: 9574189
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: February 21, 2017
    Assignee: Nuevolution A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jacobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæ Jensen, Lene Pedersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgård, Alex Haahr Gouliaev, Henrik Pedersen
  • Method for the synthesis of a bifunctional complex
    Patent number: 9487775
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: November 8, 2016
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Alex Haahr Gouliaev, Per-Ola Freskgard, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Birkebaek Jensen, Kim Birkebaek Jensen, Henrik Pedersen
  • 3-O-acyl-ingenol analogues
    Patent number: 9409931
    Abstract: The present invention relates to a compound according to formula I wherein R1 represents hydrogen, R2 represents hydroxyl and R3 represents hydroxyl; or R1 represents methyl, R2 represents hydroxyl and R3 represents hydrogen; or R1 represents methyl, R2 represents hydrogen and R3 represents hydroxyl; or R1 represents methyl, R2 represents hydrogen and R3 represents hydrogen; or pharmaceutically acceptable hydrates or solvates thereof. The invention further relates to said compounds for use as a medicament, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds and to intermediates for the preparation of said compounds.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: August 9, 2016
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Phillippe S. Baran, Jakob Felding, Yehua Jin, Chien-Hung Yeh
  • NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II
    Publication number: 20160207930
    Abstract: The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD3 or halogen; R3 is selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)haloalkyl and (C1-4)hydroxyalkyl; R4 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R5 and R6 are independently selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4) hydroxyalkyl and (C1-4)haloalkyl and X and Y are independently selected from the group consisting of CH and N. The invention furthermore relates to intermediates for the preparation of said compounds, to their use in therapy, and to pharmaceutical compositions comprising said compounds.
    Type: Application
    Filed: August 15, 2014
    Publication date: July 21, 2016
    Applicant: LEO PHARMA A/S
    Inventors: Haakan BLADH, Jakob FELDING, Ding ZHOU, Zhen-wei CAI, Morten Dahl SØRENSEN
  • METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX
    Publication number: 20160083720
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Application
    Filed: July 8, 2015
    Publication date: March 24, 2016
    Inventors: Per-Ola FRESKGARD, Thomas FRANCH, Alex Haahr GOULIAEV, Mikkel Dybro LUNDORF, Jakob FELDING, Eva Kampmann OLSEN, Anette HOLTMANN, Soeren Nyboe JAKOBSEN, Christian Klarner SAMS, Sanne Schroeder GLAD, Kim Birkebaek JENSEN, Henrik PEDERSEN
  • Method for the synthesis of a bifunctional complex
    Patent number: 9284600
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 15, 2016
    Assignee: Neuvolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schrøder Glad, Kim Birkebaek Jensen, Henrik Pedersen