Patents by Inventor Jakob Felding

Jakob Felding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11702652
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: July 18, 2023
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • Patent number: 11292788
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: April 5, 2022
    Assignee: Immunic AG
    Inventors: Jakob Felding, Hella Kohlhof, Manfred Groppel, Rolf Andreas Muhler, Daniel Vitt, Carine Chevrier, Mirko Zaja, Stefan Tasler
  • Patent number: 11001835
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: May 11, 2021
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • Patent number: 10731151
    Abstract: The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: August 4, 2020
    Assignee: NUEVOLUTION A/S
    Inventors: Henrik Pedersen, Anette Holtmann, Thomas Franch, Alex Haahr Gouliaev, Jakob Felding
  • Patent number: 10669538
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: June 2, 2020
    Assignee: NUEVOLUTION A/S
    Inventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
  • Patent number: 10287576
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 14, 2019
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jakobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæk Jensen, Lene Petersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgard, Alex Haahr Gouliaev, Henrik Pedersen
  • Patent number: 10077440
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: September 18, 2018
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • Patent number: 9688980
    Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 27, 2017
    Assignee: NUEVOLUTION
    Inventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
  • Patent number: 9574189
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: February 21, 2017
    Assignee: Nuevolution A/S
    Inventors: Thomas Franch, Mikkel Dybro Lundorf, Søren Nyboe Jacobsen, Eva Kampmann Olsen, Anne Lee Andersen, Anette Holtmann, Anders Holm Hansen, Anders Malling Sørensen, Anne Goldbech, Daen de Leon, Ditte Kievsmose Kaldor, Frank Abildgaard Sløk, Gitte Nystrup Husemoen, Johannes Dolberg, Kim Birkebæ Jensen, Lene Pedersen, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Søren Neve, Thomas Thisted, Tine Titilola Akinleminu Kronborg, Christian Klarner Sams, Jakob Felding, Per-Ola Freskgård, Alex Haahr Gouliaev, Henrik Pedersen
  • Patent number: 9487775
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: November 8, 2016
    Assignee: NUEVOLUTION A/S
    Inventors: Thomas Franch, Alex Haahr Gouliaev, Per-Ola Freskgard, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Birkebaek Jensen, Kim Birkebaek Jensen, Henrik Pedersen
  • Patent number: 9409931
    Abstract: The present invention relates to a compound according to formula I wherein R1 represents hydrogen, R2 represents hydroxyl and R3 represents hydroxyl; or R1 represents methyl, R2 represents hydroxyl and R3 represents hydrogen; or R1 represents methyl, R2 represents hydrogen and R3 represents hydroxyl; or R1 represents methyl, R2 represents hydrogen and R3 represents hydrogen; or pharmaceutically acceptable hydrates or solvates thereof. The invention further relates to said compounds for use as a medicament, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds and to intermediates for the preparation of said compounds.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: August 9, 2016
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Phillippe S. Baran, Jakob Felding, Yehua Jin, Chien-Hung Yeh
  • Patent number: 9284600
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 15, 2016
    Assignee: Neuvolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schrøder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • Patent number: 9181259
    Abstract: The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(?O)OR7 or C1-4 alkyl optionally substituted with hydroxy or NR8R9; R4 is hydrogen or oxo; R5 and R6 are independently hydrogen, hydroxy, NR8R9, C(?O)R7, C(?O)OR7, C(?O)NR8R9, C1-4 alkyl, wherein said C1-4 alkyl is optionally substituted with hydroxy, NR8R9 or a 5- or 6-membered heterocyclic ring, wherein said 5- or 6-membered heterocyclic ring is optionally substituted with C1-4 alkyl or C(?O)R7; or R5 and R6, together with the carbon atom to which they are attached, form ?CH2 or a 5- or 6-membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with C1-4 alkyl; R7 is hydrogen or C1-4 alkyl; R8 and R9 are independently hydrogen or C1-4 alkyl, or R8 and R9, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring, or a pharmaceutically accep
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 10, 2015
    Assignee: LEO PHARMA A/S
    Inventors: Morten Dahl Sørensen, Romano Di Fabio, Alfonso Pozzan, Maria Pia Catalani, Haakon Bladh, Jakob Felding
  • Patent number: 9109248
    Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: August 18, 2015
    Assignee: Nuevolution A/S
    Inventors: Per-Ola Freskgard, Thomas Franch, Alex Haahr Gouliaev, Mikkel Dybro Lundorf, Jakob Felding, Eva Kampmann Olsen, Anette Holtmann, Soeren Nyboe Jakobsen, Christian Klarner Sams, Sanne Schroeder Glad, Kim Birkebaek Jensen, Henrik Pedersen
  • Publication number: 20150018345
    Abstract: The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(?O)OR7 or C1-4 alkyl optionally substituted with hydroxy or NR8R9; R4 is hydrogen or oxo; R5 and R6 are independently hydrogen, hydroxy, NR8R9, C(?O)R7, C(?O)OR7, C(?O)NR8R9, C1-4 alkyl, wherein said C1-4 alkyl is optionally substituted with hydroxy, NR8R9 or a 5- or 6-membered heterocyclic ring, wherein said 5- or 6-membered heterocyclic ring is optionally substituted with C1-4 alkyl or C(?O)R7; or R5 and R6, together with the carbon atom to which they are attached, form ?CH2 or a 5- or 6-membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with C1-4 alkyl; R7 is hydrogen or C1-4 alkyl; R8 and R9 are independently hydrogen or C1-4 alkyl, or R8 and R9, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring, or a pharmaceutically accep
    Type: Application
    Filed: February 20, 2013
    Publication date: January 15, 2015
    Inventors: Morten Dahl Sørensen, Romano Di Fabio, Alfonso Pozzan, Maria Pia Catalani, Haakon Bladh, Jakob Felding
  • Patent number: 8932992
    Abstract: The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: January 13, 2015
    Assignee: Nuevolution A/S
    Inventors: Henrik Pedersen, Alex Haahr Gouilaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Sløk, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Nørregaard-Madsen, Michael Anders Godskesen, Sanne Schrøder Glad, Thomas Thisted, Per-Ola Freskgård, Anette Holtmann
  • Patent number: 8829190
    Abstract: The present invention relates to a compound according to formula (I), wherein X and Y are either C and N or N and C; Z is CH2, CH2—CH2, CH2—NH, or NH; R1 is halogen, or R1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkyl, alkoxycarbonyl, aryl, all of which are optionally substituted; R2 is hydrogen, or R2 is alkyl, cycloalkyl, alkoxy, heterocycloalkyl, aryl, heteroaryl, alkoxycarbonyl, aminocarbonyl, amino, all of which are optionally substituted; A is aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl, all of which are optionally substituted; and pharmaceutically acceptable salts, hydrates, or solvates hereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments, in particular for the treatment of dermal diseases.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: September 9, 2014
    Assignee: Leo Pharma A/S
    Inventors: Jakob Felding, Morten Dahl Sørensen
  • Patent number: 8808984
    Abstract: The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: August 19, 2014
    Assignee: Neuvolution A/S
    Inventors: Henrik Pedersen, Anette Holtmann, Thomas Franch, Alex Haahr Gouliaev, Jakob Felding
  • Patent number: 8497380
    Abstract: The present invention relates to a compound according to formula: (1); wherein X1, X2, X3, X4 and X5 independently of each other represent —CH— or N; or X3, X4 and X5 independently of each other represent —CH— or N, and X1 and X2 independently of each other represent C and form part of an additional 6-membered aromatic ring; R1 represents hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, or alkylcarbonyl, all of which are optionally substituted; R2 and R3 independently represent hydrogen, —CH2, —C(O)NR—R?, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, haloalkyl, hydroxyalkyl, heterocycloalkenyl, alkylaryl, alkylalkoxycarbonyl, aikylcarbonyloxy, or alkoxyalkyl, all of which are optionally substituted; R11 represents hydrogen, halogen, cyano, amino, alkoxy or alkylamino, X1-X5 represent —CH— or N, including N-oxides, enantiomers and diastereomers; and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to methods of treating dermal disease.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: July 30, 2013
    Assignee: Leo Pharma A/S
    Inventors: Jakob Felding, Simon Feldbæk Nielsen
  • Patent number: 8350026
    Abstract: The invention relates to compounds of general formula (I) wherein W, D, E, G, J, L, R1, R2, R3, R4, R5 and Y are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer and skin and eye diseases.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: January 8, 2013
    Assignee: Leo Pharma A/S
    Inventors: Jakob Felding, Xifu Liang, Anne Marie Horneman, Tina Dahlerup Poulsen, Jens Christian Højland Larsen