Patents by Inventor Jakob Magolan

Jakob Magolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY PHENYL COMPOUNDS
    Publication number: 20240317660
    Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted.
    Type: Application
    Filed: June 23, 2022
    Publication date: September 26, 2024
    Applicant: McMaster University
    Inventors: Jakob Magolan, Xiong Zhang, Nicholas Jentsch, Mathew Piotrowski, Meghan Fragis, Jarrod Johnson, Lauren Irwin
  • Synthetic antibacterial compounds and uses thereof
    Patent number: 12011422
    Abstract: Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: June 18, 2024
    Assignee: McMaster University
    Inventors: Eric Brown, Omar M Elhalfawy, Nick Jentsch, Xiong Zhang, Jakob Magolan
  • PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS
    Publication number: 20240150269
    Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (1) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (1).
    Type: Application
    Filed: September 26, 2023
    Publication date: May 9, 2024
    Applicant: McMaster University
    Inventors: Jakob Magolan, Nicholas Jentsch, Xiong Zhang, Mathew Piotrowski, Patrick Darveau, Meghan Fragis, Jarrod Johnson, Nicole Ritchie, Arnav Kaul
  • Processes for the preparation of ortho-allylated hydroxy aryl compounds
    Patent number: 11795127
    Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: October 24, 2023
    Assignee: McMaster University
    Inventors: Jakob Magolan, Nicholas Jentsch, Xiong Zhang, Mathew Piotrowski, Patrick Darveau, Meghan Fragis, Jarrod Johnson, Nicole Ritchie, Arnav Kaul
  • PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS
    Publication number: 20230113567
    Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
    Type: Application
    Filed: October 12, 2022
    Publication date: April 13, 2023
    Inventors: Jakob Magolan, Nicholas Jentsch, Xiong Zhang, Mathew Piotrowski, Patrick Darveau, Meghan Fragis, Jarrod Johnson, Nicole Ritchie, Arnav Kaul
  • Synthetic Antibacterial Compounds and Uses Thereof
    Publication number: 20220401384
    Abstract: Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.
    Type: Application
    Filed: May 27, 2022
    Publication date: December 22, 2022
    Inventors: Eric Brown, Omar M Elhalfawy, Nick Jentsch, Xiong Zhang, Jakob Magolan
  • Processes for the preparation of -allylated hydroxy aryl compounds
    Patent number: 11512034
    Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: November 29, 2022
    Assignee: McMaster University
    Inventors: Jakob Magolan, Nicholas Jentsch, Xiong Zhang, Mathew Piotrowski
  • Synthetic Antibacterial Compounds and Uses Thereof
    Publication number: 20220017482
    Abstract: Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium or treating or preventing a bacterial infection.
    Type: Application
    Filed: November 20, 2019
    Publication date: January 20, 2022
    Inventors: Eric Brown, Omar M Elhalfawy, Maya Farha, Jakob Magolan, Robert Gale