Patents by Inventor Jakob Peter Ley

Jakob Peter Ley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240130408
    Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.
    Type: Application
    Filed: February 22, 2021
    Publication date: April 25, 2024
    Inventors: Tobias TRAPP, Torsten GEISSLER, Jakob Peter LEY, Jens KOCH, Gerhard KRAMMER, Suzan YALMAN, Marco FRAATZ, Holger ZORN
  • Publication number: 20230407349
    Abstract: The present invention relates to biotechnological methods for the production of saturated as well as unsaturated aldehydes, and mixtures thereof using at least one alpha-dioxygenase and at least one aldehyde dehydrogenase. The method may be carried out either fermentatively or enzymatically. Furthermore, the present invention relates to a vector system, as well as sequences and recombinant microorganisms encoding the enzymes that can be used to produce the aldehydes and mixtures according to the invention. Further, the present invention relates to compositions obtained by the methods according to the present invention.
    Type: Application
    Filed: March 12, 2020
    Publication date: December 21, 2023
    Inventors: Torsten GEISSLER, Jakob Peter LEY, Michael BACKES, Christoph HARMS, Uwe BORNSCHEUER, Kathleen BALKE, Holger ZORN, Marco Alexander FRAATZ, Andreas HAMMER
  • Publication number: 20230279451
    Abstract: The present invention relates to a biocatalytical method for manufacturing of homoeriodictyol dihydrochalcone and/or hesperetin dihydrochalcone by providing at least one first biocatalyst system for the hydroxylation of phloretin and/or its glycosides as well as at least one second biocatalyst for the methylation of 3-hydroxyphloretin. Further disclosed are microorganisms capable of producing such biocatalysts as well as sequences encoding the biocatalysts. Furthermore, the present invention relates to the use of a mixture obtained by a method as disclosed in the present invention and to specific compositions suitable as sweetness enhancers and/or flavouring agents.
    Type: Application
    Filed: September 25, 2020
    Publication date: September 7, 2023
    Inventors: Torsten GEISSLER, Jakob Peter LEY, Bastian ZIRPEL
  • Patent number: 11535584
    Abstract: Compounds of formula (I) and novel uses of compounds of formula (I), such as for flavour compositions. New preparations and new methods using compounds of formula (I).
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: December 27, 2022
    Assignee: SYMRISE AG
    Inventors: Michael Backes, Jakob Peter Ley, Andreas Degenhardt, Susanne Paetz, Katharina Reichelt, Thomas Riess, Bettina Klose, Fabia Hentschel
  • Publication number: 20220346419
    Abstract: The present invention primarily relates to a mixture comprising or consisting of components a), b) and c), and optionally component d), wherein component a) is at least one rare sugar, component b) is at least one taste modifying compound, component c) is at least one natural sweet tasting compound, and component d) is at least one natural caloric sweet-tasting carbohydrate and/or at least one non-caloric sweet tasting sugar alcohol.
    Type: Application
    Filed: January 14, 2020
    Publication date: November 3, 2022
    Inventors: Thomas RIESS, Gerhard KRAMMER, Jakob Peter LEY, Katharina REICHELT, Susanne PAETZ, Tom SOMERS
  • Publication number: 20220046969
    Abstract: The present invention primarily relates to a mixture comprising or consisting of a) D-allulose and b) a taste modifying compound selected from the group consisting of hesperetin, hersperetindihydrochalcone, phloretin, glycosylated rubusosides, balansines, phyllodulcin, eriodictyol, homoeriodictyol, matairesinol, and mixtures thereof. A further aspect of the present invention relates to a food or beverage product comprising a mixture according to the present invention.
    Type: Application
    Filed: February 20, 2020
    Publication date: February 17, 2022
    Inventors: Deborah KENNISON, Melanie CROCE, Thomas RIESS, Gerhard KRAMMER, Jakob Peter LEY, Katharina REICHELT, Susanne PAETZ, Tom SOMERS, Morine VERWOHLT
  • Patent number: 11197491
    Abstract: The present invention relates to a flavour mixture containing 2E,4Z,7Z- and 2E,4E,7Z-tridecatrienal. This flavour mixture can be produced advantageously from arachidonic acid or oils containing esters thereof.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: December 14, 2021
    Assignee: SYMRISE AG
    Inventors: Jekaterina Ongouta, Michael Backes, Jakob Peter Ley, Volkmar Koppe, Jens Koch
  • Patent number: 11013714
    Abstract: The present invention primarily relates to the use of Homoeriodictyol (HED) or a salt thereof or a mixture of HED and one or more salts thereof or a mixture of several salts thereof for reducing the gastric acid secretion-stimulating effect of N-Acetyl-4-aminophenol (Paracetamol).
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: May 25, 2021
    Assignee: SYMRISE AG
    Inventors: Joachim Hans, Jakob Peter Ley, Susanne Paetz, Silke Middendorf, Kathrin Liszt, Veronika Somoza
  • Patent number: 10988786
    Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: April 27, 2021
    Assignees: SYMRISE AG, LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIE
    Inventors: Ludger A. Wessjohann, Susann Herrmann, Martin Dippe, Torsten Geissler, Katrin Geissler, Jakob Peter Ley
  • Publication number: 20210040028
    Abstract: Compounds of formula (I) and novel uses of compounds of formula (I), such as for flavour compositions. New preparations and new methods using compounds of formula (I).
    Type: Application
    Filed: October 22, 2020
    Publication date: February 11, 2021
    Inventors: Michael Backes, Jakob Peter Ley, Andreas Degenhardt, Susanne Paetz, Katharina Reichelt, Thomas Riess, Bettina Klose, Fabia Hentschel
  • Patent number: 10869493
    Abstract: A flavoring mixture, comprising (i) one or more sweet-tasting substances, selected from the group of naturally occurring sweet-tasting substances and the physiologically compatible salts thereof without phyllodulcin and the physiologically compatible salts thereof, and (ii) phyllodulcin and/or one or more of the physiologically compatible salts thereof, wherein the ratio of the sucrose equivalence of the concentration of the substance or substances of group (i) to the sucrose equivalence of the concentration of the substance or substances of group (i) is ?2.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: December 22, 2020
    Assignee: SYMRISE AG
    Inventors: Katharina Reichelt, Jakob Peter Ley, Petra Hoffmann-Lücke, Maria Blings, Susanne Paetz, Thomas Riess
  • Publication number: 20200205445
    Abstract: A flavoring mixture, comprising (i) one or more sweet-tasting substances, selected from the group of naturally occurring sweet-tasting substances and the physiologically compatible salts thereof without phyllodulcin and the physiologically compatible salts thereof, and (ii) phyllodulcin and/or one or more of the physiologically compatible salts thereof, wherein the ratio of the sucrose equivalence of the concentration of the substance or substances of group (i) to the sucrose equivalence of the concentration of the substance or substances of group (i) is ?2.
    Type: Application
    Filed: March 11, 2020
    Publication date: July 2, 2020
    Inventors: Katharina REICHELT, Jakob Peter Ley, Petra Hoffmann-Lücke, Maria Blings, Susanne Paetz, Thomas Riess
  • Patent number: 10624372
    Abstract: A flavoring mixture, comprising (i) one or more sweet-tasting substances, selected from the group of naturally occurring sweet-tasting substances and the physiologically compatible salts thereof without phyllodulcin and the physiologically compatible salts thereof, and (ii) phyllodulcin and/or one or more of the physiologically compatible salts thereof, wherein the ratio of the sucrose equivalence of the concentration of the substance or substances of group (i) to the sucrose equivalence of the concentration of the substance or substances of group (i) is ?2.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: April 21, 2020
    Assignee: SYMRISE AG
    Inventors: Katharina Reichelt, Jakob Peter Ley, Petra Hoffmann-Lücke, Maria Blings, Susanne Paetz, Thomas Riess
  • Publication number: 20190289887
    Abstract: The present invention relates to a flavour mixture containing 2E,4Z,7Z- and 2E,4E,7Z-tridecatrienal. This flavour mixture can be produced advantageously from arachidonic acid or oils containing esters thereof.
    Type: Application
    Filed: June 2, 2016
    Publication date: September 26, 2019
    Inventors: Jekaterina ONGOUTA, Michael BACKES, Jakob Peter LEY, Volkmar KOPPE, Jens KOCH
  • Publication number: 20190276386
    Abstract: Compounds of formula (I) and novel uses of compounds of formula (I), such as for flavour compositions. New preparations and new methods using compounds of formula (I).
    Type: Application
    Filed: April 14, 2015
    Publication date: September 12, 2019
    Inventors: Michael BACKES, Jakob Peter LEY, Andreas DEGENHARDT, Susanne PAETZ, Katharina REICHELT, Thomas RIESS, Bettina KLOSE, Fabia HENTSCHEL
  • Publication number: 20190194707
    Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.
    Type: Application
    Filed: September 30, 2016
    Publication date: June 27, 2019
    Inventors: Ludger A. WESSJOHANN, Susann HERRMANN, Martin DIPPE, Torsten GEISSLER, Katrin GEISSLER, Jakob Peter LEY
  • Publication number: 20190127314
    Abstract: The present invention particularly relates to new uses of compounds of formula (I) (as described herein) for inhibiting or reducing the absorption of free fatty acids in the small intestine, as well as a new compound of formula (I) as such, aroma compositions and new compositions comprising such a compound of formula (I). Further aspects of the present invention result from the patent claims and the subsequent description including the examples.
    Type: Application
    Filed: March 23, 2016
    Publication date: May 2, 2019
    Inventors: Joachim HANS, Barbara LIEDER, Katrin GEISSLER, Fabia HENTSCHEL, Jakob Peter LEY, Veronika SOMOZA
  • Publication number: 20190091199
    Abstract: The present invention primarily relates to the use of Homoeriodictyol (HED) or a salt thereof or a mixture of HED and one or more salts thereof or a mixture of several salts thereof for reducing the gastric acid secretion-stimulating effect of N-Acetyl-4-aminophenol (Paracetamol).
    Type: Application
    Filed: April 19, 2017
    Publication date: March 28, 2019
    Inventors: Joachim HANS, Jakob Peter LEY, Susanne PAETZ, Silke MIDDENDORF, Kathrin LISZT, Veronika SOMOZA
  • Patent number: 10227620
    Abstract: The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4?-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method. The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 12, 2019
    Assignee: SYMRISE AG
    Inventors: Gerhard Krammer, Jakob Peter Ley, Katrin Geißler, Torsten Geißler, Frauke Gomoll, Peter Welters, Guido Jach, Ludger Wessjohann
  • Patent number: 10165791
    Abstract: The invention relates to the use of rubusoside and certain mixtures containing rubusoside, preferably the use of certain rubusoside-containing mixtures, in particular Rubus suavissimus extracts, for masking, reducing or suppressing a bitter, sour and/or astringent taste impression. The invention further relates to orally consumable preparations, comprising at least one bitter, sour and/or astringent-tasting substance and rubusoside or certain rubusoside-containing mixtures, preferably certain Rubus suavissimus extracts, a corresponding method of producing said preparations and a method for reducing or suppressing the bitter, sour and/or astringent effect of a bitter, sour and/or astringent-tasting substance. The invention further relates to certain flavoring compositions that are particularly effective for masking, reducing or suppressing a bitter, sour and/or astringent taste impression.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: January 1, 2019
    Assignee: Symrise AG
    Inventors: Jakob Peter Ley, Katharina Reichelt, Thomas Riess, Kathrin Langer, Susanne Paetz