Abstract: The present invention is directed to a method for continuous production of cationic lipids. Said cationic lipids are particularly useful in combination with other lipid components for forming lipid nanoparticles with oligonucleotides (e.g. mRNA) to facilitate delivery of therapeutically active nucleic acids.

Abstract: The disclosure concerns the chamber of a head box for a paper making machine. Movable partition walls extend between the side walls of the chamber. Opposed stub shafts in the opposite side walls of the chamber carry eccentric journal pins which are received in respective partition walls, such that rotation of each stub shaft adjusts the position of the respective engaged partition wall. A second concentric pin on each stub shaft also engages the respective partition wall, whereby the eccentric pin may move the partition wall while the concentric pin may guide the movement. Appropriate longitudinally extending grooves are defined in the partition wall to absorb the motion caused by rotation of the stub shaft, which moves the partition wall with respect to the stub shaft. As appropriate, there may be respective generally mutually perpendicular longitudinally extending grooves for the concentric and eccentric pins, respectively.

Abstract: Apparatus for forming one or more sheets from a dilute suspension of fibers in a liquid has a Fourdrinier wire the upper reach of which travels above a foraminous support, and a head box which has an outlet discharging the suspension onto the upstream portion of the upper reach. The liquid passes through the wire and support, and the fibers form a mat which is carried and advanced by the upper reach of the wire. The apparatus has several deckles which are impervious to liquid and are mounted in or on the support or at a level immediately above the upper reach of the wire. Each deckle extends lengthwise of the entire outlet of the head box and its width is only a small fraction of the width of the outlet. Feed screws or the like are used for moving the deckles sideways so that they overlie selected elongated zones of the upstream portion of the upper reach of the wire, and each deckle can be releasably fixed in the selected position.