Patents by Inventor Jakub TOCZEK

Jakub TOCZEK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds For Molecular Imaging of Collagen Turnover and Methods Using Same
    Publication number: 20240298987
    Abstract: In one aspect, the present disclosure relates to an imaging agent comprising a detectable moiety covalently bound or coordinated to a “Moiety A” selected from a peptide, a chelator, or an organic compound comprising a leaving atom or a leaving group that can be substituted with a radioisotope. “Moiety A” is covalently bound to a flexible linker which is further covalently bound to a polypeptide of between 2 and 20 glycine-proline-hydroxyproline repeats. In certain embodiments, the detectable moiety comprises a radioisotope or metal. In another aspect, the disclosure relates to a method of using the imaging agents of the present disclosure to detect collagen turnover in a subject.
    Type: Application
    Filed: June 22, 2022
    Publication date: September 12, 2024
    Inventors: Mehran Sadeghi, Mani Salarian, Kiran Gona, Jakub Toczek
  • Matrix Metalloproteinase Inhibitors and Imaging Agents, And Methods Using Same
    Publication number: 20220194930
    Abstract: The present invention provides certain compounds, or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 23, 2022
    Inventors: Mehran SADEGHI, Yunpeng YE, Hye-Yeong KIM, Henry(Yiyun) HUANG, Jakub TOCZEK
  • Matrix metalloproteinase inhibitors and imaging agents, and methods using same
    Patent number: 11286251
    Abstract: The present invention provides certain compounds, or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: March 29, 2022
    Assignees: YALE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Mehran Sadeghi, Yunpeng Ye, Hye-Yeong Kim, Henry(Yiyun) Huang, Jakub Toczek
  • Matrix Metalloproteinase Inhibitors and Imaging Agents, And Methods Using Same
    Publication number: 20200283428
    Abstract: The present invention provides certain compounds, Formula (I), or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents.
    Type: Application
    Filed: April 7, 2017
    Publication date: September 10, 2020
    Inventors: Mehran SADEGHI, Yunpeng YE, Hye-Yeong KIM, Henry(Yiyun) HUANG, Jakub TOCZEK