Patents by Inventor Jakub WITKOWSKI

Jakub WITKOWSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53
    Publication number: 20260200932
    Abstract: The invention relates to 1,2,3?,5?-tetrahydro-2?H-spiro[indole-3,1?-pyrrolo[3,4-c]pyrrole]-2,3?-dione compounds represented by formula (1), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, blinding disease and viral infections.
    Type: Application
    Filed: August 26, 2025
    Publication date: July 16, 2026
    Inventors: Marcin FEDER, Maria MAZUR, Iwona KALINOWSKA, Joanna JASZCZEWSKA-ADAMCZAK, Wojciech LEWANDOWSKI, Jakub WITKOWSKI, Sabina JELEN, Katarzyna WOS-LATOSI
  • MULTI-MODAL MACHINE LEARNING APPROACHES FOR PREDICTING CANCER TYPE AND GLEASON GRADE LEVERAGING PUBLIC TCGA DATA
    Publication number: 20250316387
    Abstract: The invention relates to a method of diagnosing or determining the prognosis of cancer in a patient, the method comprising processing, using RNA-sequencing and a first machine learning model, the genomic data of the patient to determine at least one of a first cancer type or degree of cancer and processing, using histopathology and a second machine learning model, the biopsy image data of the patient to determine at least one of a second cancer type or degree of cancer and comparing the determined first type or degree of cancer with the determined second type or degree of cancer and correlating the two.
    Type: Application
    Filed: May 6, 2025
    Publication date: October 9, 2025
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Mohammad Ashtari, Ofir Etz Hadar, Jacob Gildenblat, Michael King, Eldad Klaiman, Antoaneta Petkova Vladimirova, Jakub Witkowski, Christian Wohlfart
  • 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-C]pyrrole]-2,3'-dione compounds as therapeutic agents activating TP53
    Patent number: 12415811
    Abstract: The invention relates to 1,2,3?,5?-tetrahydro-2?H-spiro[indole-3,1?-pyrrolo[3,4-c]pyrrole]-2,3?-dione compounds represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, blinding disease and viral infections.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: September 16, 2025
    Assignee: ADAMED PHARMA S.A.
    Inventors: Marcin Feder, Maria Mazur, Iwona Kalinowska, Joanna Jaszczewska-Adamczak, Wojciech Lewandowski, Jakub Witkowski, Sabina Jelen, Katarzyna Wos-Latosi
  • 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53
    Publication number: 20200354372
    Abstract: The invention relates to 1,2,3?,5?-tetrahydro-2?H-spiro[indole-3,1?-pyrrolo[3,4-c]pyrrole]-2,3?-dione compounds represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, blinding disease and viral infections.
    Type: Application
    Filed: January 9, 2019
    Publication date: November 12, 2020
    Inventors: Marcin FEDER, Maria MAZUR, Iwona KALINOWSKA, Joanna JASZCZEWSKA-ADAMCZAK, Wojciech LEWANDOWSKI, Jakub WITKOWSKI, Sabina JELEN, Katarzyna WOS-LATOSI