Patents by Inventor James A. Beatty
James A. Beatty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11492579Abstract: High-throughput column arrays of vascularized living parenchyma/tissue having pillars dispersed in specialized configurations and arrangements substantially vertically through the column to provide support, passive or active perfusion, and access to internal portions of tissue for analytical sampling needs, along with 3-D printing methods of manufacture and analytical screening methods employing the column arrays.Type: GrantFiled: April 13, 2018Date of Patent: November 8, 2022Assignee: Advanced Solutions Life Sciences, LLCInventor: James Beatty Hoying
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Publication number: 20210214662Abstract: High-throughput column arrays of vascularized living parenchyma/tissue having pillars dispersed in specialized configurations and arrangements substantially vertically through the column to provide support, passive or active perfusion, and access to internal portions of tissue for analytical sampling needs, along with 3-D printing methods of manufacture and analytical screening methods employing the column arrays.Type: ApplicationFiled: April 13, 2018Publication date: July 15, 2021Inventor: James Beatty Hoying
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Patent number: 10457929Abstract: The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain (or a biologically active fragment, analogue or variant thereof) alone or in combination with other suitable enzymes including bromelain, and/or an intestinal extract, as herein described. The present invention also provides methods of using such compositions for the prophylaxis or treatment of a condition arising from gluten intolerance.Type: GrantFiled: September 24, 2018Date of Patent: October 29, 2019Assignee: Glutagen Pty Ltd.Inventors: Teodor Stelmasiak, Hugh James Beatty Cornell
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Patent number: 10414859Abstract: Polyester polyols made from thermoplastic polyesters are disclosed. The polyols are reaction products of a thermoplastic polyester, a glycol, and a hydrophobe selected from ricinoleic acid, ethoxylated castor oil, saturated or unsaturated C9-C18 dicarboxylic acids, tung oil, soybean oil, sunflower oil, cardanol-based products, recycled cooking oil, isostearyl alcohol, hydroxy-functional materials derived from epoxidized, ozonized, or hydroformylated fatty esters or fatty acids, and mixtures thereof. In one process, the polyols are made by reacting the thermoplastic polyester with a glycol to give a digested intermediate, which is then reacted with the hydrophobe. In another process, the thermoplastic polyester, glycol, and hydrophobe are combined and reacted in a single step. These hydrophobes facilitate the production from recycled thermoplastics of polyols that have good transparency and little or no particulate settling or phase separation.Type: GrantFiled: October 19, 2015Date of Patent: September 17, 2019Assignee: RESINATE MATERIALS GROUP, INC.Inventors: Rick Tabor, Kevin Anthony Rogers, Eric D Vrabel, Matthew James Beatty, Woo-Sung Bae, Shakti L Mukerjee
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Publication number: 20190010477Abstract: The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain (or a biologically active fragment, analogue or variant thereof) alone or in combination with other suitable enzymes including bromelain, and/or an intestinal extract, as herein described. The present invention also provides methods of using such compositions for the prophylaxis or treatment of a condition arising from gluten intolerance.Type: ApplicationFiled: September 24, 2018Publication date: January 10, 2019Inventors: Teodor Stelmasiak, Hugh James Beatty Cornell
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Patent number: 10100296Abstract: The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain (or a biologically active fragment, analog or variant thereof) alone or in combination with other suitable enzymes including bromelain, and/or an intestinal extract, as herein described. The present invention also provides methods of using such compositions for the prophylaxis or treatment of a condition arising from gluten intolerance.Type: GrantFiled: January 6, 2010Date of Patent: October 16, 2018Assignee: Glutagen Pty LtdInventors: Teodor Stelmasiak, Hugh James Beatty Cornell
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Patent number: 9988489Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: GrantFiled: July 31, 2017Date of Patent: June 5, 2018Assignee: Resinate Materials Group, Inc.Inventors: Shakti Mukerjee, Kevin Anthony Rogers, Matthew James Beatty, Gary E. Spilman
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Publication number: 20170335057Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a hydroxy-functional ketal acid, ester or amide. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the hydroxy-functional ketal acid, ester or amide. The resulting polyols have good transparency and little or no particulate settling or phase separation. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including aqueous polyurethane dispersions, flexible and rigid foams, coatings, adhesives, sealants, and elastomers can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: ApplicationFiled: October 27, 2015Publication date: November 23, 2017Inventors: Rick Tabor, Eric David Vrabel, Kevin Anthony Rogers, Matthew James Beatty, Woo-Sung Bae, Jack Rogers Kovsky, Michael Robert Christy
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Publication number: 20170327638Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: ApplicationFiled: July 31, 2017Publication date: November 16, 2017Inventors: Shakti Mukerjee, Kevin Anthony Rogers, Matthew James Beatty, Gary E. Spilman
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Patent number: 9751978Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: GrantFiled: September 15, 2016Date of Patent: September 5, 2017Assignee: Resinate Materials Group, Inc.Inventors: Shakti Mukerjee, Kevin Anthony Rogers, Matthew James Beatty, Gary E. Spilman
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Patent number: 9732026Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to oligomeric reaction products formed by the depolymerization of polyethylene terephthalate polymers and methods thereof. More specifically, the presently disclosed and/or claimed inventive concept(s) relates to oligomeric reaction products formed by the depolymerization of polyethylene terephthalate polymer obtained from, for example but not by way of limitation, waste products, such as beverage containers made from polyethylene terephthalate (PET). The oligomeric reaction products can, in one embodiment, be used as a starting material for polyurethanes. The presently disclosed and/or claimed inventive concept(s) also relates to processes for producing oligomeric reaction products from the depolymerization of polyethylene terephthalate.Type: GrantFiled: December 17, 2013Date of Patent: August 15, 2017Assignee: Resinate Technologies, Inc.Inventors: Rick Tabor, Daniel James Seyer, Kristopher M Felice, Adam W Emerson, Matthew Thomas Brown, Kyle Harris McGrath, Mickey Kellerman, Kevin Anthony Rogers, Jack Rogers Kovsky, Matthew James Beatty, Eric David Vrabel
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Publication number: 20170002138Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: ApplicationFiled: September 15, 2016Publication date: January 5, 2017Inventors: Shakti Mukerjee, Kevin Anthony Rogers, Matthew James Beatty, Gary E. Spilman
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Patent number: 9506035Abstract: The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. In some embodiments, the SVF cells can be on the surface or embedded within a three-dimensional matrix. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.Type: GrantFiled: October 13, 2010Date of Patent: November 29, 2016Assignee: University of Louisville Research Foundation, IncInventors: Stuart K. Williams, James Beatty Hoying, Laxminarayanan Krishnan
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Patent number: 9481760Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: GrantFiled: March 24, 2016Date of Patent: November 1, 2016Assignee: Resinate Materials Group, Inc.Inventors: Shakti Mukerjee, Kevin Anthony Rogers, Matthew James Beatty, Gary E. Spilman
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Publication number: 20160208044Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.Type: ApplicationFiled: March 24, 2016Publication date: July 21, 2016Inventors: Shakti Mukerjee, Kevin Anthony Rogers, Matthew James Beatty, Gary E. Spilman
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Patent number: 9389292Abstract: A system and method for combining k-space data acquired on multiple different receiver channels in a multichannel receiver is provided. One or more convolution kernels are used to combine the k-space data. Each convolution kernel is designed as the combination of one or more channel combination kernels and an alias-suppressing kernel. The channel combination kernels are designed to have a smaller sample spacing than the acquired data, and the alias-suppressing kernel is designed to suppress aliasing artifacts in stopbands defined by the sample spacing of the channel combination kernels.Type: GrantFiled: September 30, 2014Date of Patent: July 12, 2016Assignee: SUNNYBROOK RESEARCH INSTITUTEInventor: Philip James Beatty
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Publication number: 20160053050Abstract: Polyester polyols made from thermoplastic polyesters are disclosed. The polyols are reaction products of a thermoplastic polyester, a glycol, and a hydrophobe selected from ricinoleic acid, ethoxylated castor oil, saturated or unsaturated C9-C18 dicarboxylic acids, tung oil, soybean oil, sunflower oil, cardanol-based products, recycled cooking oil, isostearyl alcohol, hydroxy-functional materials derived from epoxidized, ozonized, or hydroformylated fatty esters or fatty acids, and mixtures thereof. In one process, the polyols are made by reacting the thermoplastic polyester with a glycol to give a digested intermediate, which is then reacted with the hydrophobe. In another process, the thermoplastic polyester, glycol, and hydrophobe are combined and reacted in a single step. These hydrophobes facilitate the production from recycled thermoplastics of polyols that have good transparency and little or no particulate settling or phase separation.Type: ApplicationFiled: October 19, 2015Publication date: February 25, 2016Inventors: Rick Tabor, Kevin Anthony Rogers, Eric D Vrabel, Matthew James Beatty, Woo-Sung Bae, Shakti L Mukerjee
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Patent number: 9239367Abstract: In an embodiment, a method includes processing magnetic resonance (MR) data according to a process including applying a density filter to blades of k-space data rotated about a section of k-space. Each blade may include a first set of encode lines weighted in a first signal weighting and a second set of encode lines weighted in a second signal weighting. The density filter may be configured to preferentially weight each blade in the first signal weighting to produce blades of weighted k-space data.Type: GrantFiled: September 14, 2012Date of Patent: January 19, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: James Hartman Holmes, Philip James Beatty
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Publication number: 20150315325Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to oligomeric reaction products formed by the depolymerization of polyethylene terephthalate polymers and methods thereof. More specifically, the presently disclosed and/or claimed inventive concept(s) relates to oligomeric reaction products formed by the depolymerization of polyethylene terephthalate polymer obtained from, for example but not by way of limitation, waste products, such as beverage containers made from polyethylene terephthalate (PET). The oligomeric reaction products can, in one embodiment, be used as a starting material for polyurethanes. The presently disclosed and/or claimed inventive concept(s) also relates to processes for producing oligomeric reaction products from the depolymerization of polyethylene terephthalate.Type: ApplicationFiled: December 17, 2013Publication date: November 5, 2015Inventors: Rick L. Tabor, Daniel James Seyer, Kristopher M Felice, Adam W. Emerson, Matthew Thomas Brown, Kyle Harris McGrath, Mickey Kellerman, Kevin Anthony Rogers, Jack Rogers Kovsky, Matthew James Beatty, Eric David Vrabel
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Patent number: 9103898Abstract: A method includes the acts of acquiring a blade of k-space calibration data; acquiring a set of T1-weighted k-space imaging data, the set of T1-weighted k-space imaging data having blades of undersampled k-space data rotated about a section of k-space. Each blade of undersampled k-space data includes first data points having acquired data and second data points that are missing data. The method also includes generating a set of reconstruction weights for the blades of undersampled k-space data using the blade of k-space calibration data; synthesizing k-space data for at least a portion of the second data points using the set of reconstruction weights; and generating a T1-weighted image using the T1-weighted k-space imaging data and the synthesized k-space data.Type: GrantFiled: April 18, 2012Date of Patent: August 11, 2015Assignee: GENERAL ELECTRIC COMPANYInventors: James Hartman Holmes, Jean Helen Brittain, Reed Frederick Busse, Ajeetkumar Gaddipati, Xiaoli Zhao, Philip James Beatty, Zhiqiang Li, Howard Andrew Rowley