Abstract: Methods are provided for delivering a treatment therapy to treat an organ diagnosed with a disease state. The methods include delivering a first therapeutic agent into systemic circulation at a first flow rate, and delivering a second therapeutic agent directly into a vessel feeding the organ at a higher second flow rate than the first flow rate in a manner that prevents the second treatment agent from circulating systemically.

Abstract: An SMA actuator assembly (1a) for driving or rotating a movable part (20) in a predetermined direction or sense by a plurality of repeated incremental steps is provided. The SMA actuator assembly comprises the movable part; a first engagement portion (31) for engaging the movable part; two SMA wires (41, 42) arranged to move the first engagement portion such that the first engagement portion repeatedly, for each of said incremental steps, is configured to do the following: engage with the movable part from a starting position, exert a force or torque on the movable part in the predetermined direction and disengage from the movable part and return to the starting position. The exertion of the force or torque on the movable part and the engaging or disengaging with the movable part are caused by contraction or relaxation of the two SMA wires.

Abstract: Broadly speaking, the present techniques provide specific arrangements of shape memory alloy (SMA) actuator wires in SMA actuation apparatuses. In one arrangement, a single straight shape memory alloy actuator wire may be used, which may be inclined at an acute angle greater than 0 degrees with respect to a plane normal to the movement direction. In another arrangement, two straight lengths of shape memory alloy actuator wire may be used, where the SMA wires may be inclined at an acute angle greater than 0 degrees with respect to a plane normal to the movement direction.

Abstract: Features are applied to a mathematical model to produce a cutting pattern for opening a container. The cutting pattern specifies which of one or more cutting tools is to be used and the location of where cuts are to be made on the container. The cutting pattern is sent to a container opening machine. The container opening machine is operated and the container cut and opened by the container opening machine according to the cutting pattern.

Abstract: An automated container cutting system includes a cutting tool configured to cut a container and a force feedback sensor operatively connected to the cutting tool. The force feedback sensor is configured to measure resistive force exerted on the cutting tool. The automated container cutting system includes a processor communicatively coupled to the force feedback sensor. The processor is configured to receive resistive force data from the force feedback sensor and determine whether the cutting tool has penetrated through the wall of the container using the received resistive force data.

Abstract: An actuator assembly comprises: first (20) and second (10) parts, wherein a primary axis (P) is defined with reference to the second part; a plurality of lengths of shape-memory alloy wire (30) connected between the first and second parts, wherein the lengths of wire are configured, when selectively powered, to cause three-dimensional movement of the first part relative to the second part; and a mechanism configured, when the lengths of wire are unpowered, to hold the first part in at least one position and/or orientation relative to the second part against the force of gravity for any orientation of the second part.

Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Abstract: An actuator assembly comprising: a support structure comprising a first friction surface; a movable part comprising a second friction surface engaging the first friction surface; one or more SMA wires arranged, on contraction, to move the movable part relative to the support structure to any position within a range of movement; a biasing arrangement arranged to bias the first and second friction surfaces against each other with a normal force, thereby generating a static frictional force that constrains the movement of the movable part relative to the support structure at any position within the range of movement when the one or more SMA wires are not contracted; wherein the one or more SMA wires are arranged, on contraction, to reduce the normal force between first and second friction surfaces.

Abstract: An actuator assembly (1) comprising: a support structure (10) comprising a first friction surface (10f); a movable part (20) comprising a second friction surface (20f) engaging the first friction surface; one or more SMA wires (40) arranged, on contraction, to move the movable part relative to the support structure to any position within a range of movement; a biasing arrangement (30) arranged to bias the first and second friction surfaces against each other with a normal force, thereby generating a static frictional force that constrains the movement of the movable part relative to the support structure at any position within the range of movement when the one or more SMA wires are not contracted, wherein the one or more SMA wires are arranged such that the normal force between the first and second friction surfaces remains substantially constant on contraction of the one or more SMA wires.

Abstract: Features are applied to a mathematical model to produce a cutting pattern for opening a container. The cutting pattern specifies which of one or more cutting tools is to be used and the location of where cuts are to be made on the container. The cutting pattern is sent to a container opening machine. The container opening machine is operated and the container cut and opened by the container opening machine according to the cutting pattern.

Abstract: A parent tote container is segmented into smaller, child tote containers. Each of the child tote containers includes products that are commonly sold together and are removed from the tote containers at picker stations with the same type of picker mechanism. Items are moved from the child tote containers to a customer order tote container at a picker station.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.

Abstract: First scanned images of the first container are received from a scanning device that show the contents of the interior of the first container before the first container is cut and opened. Second scanned images that are of the contents of the first container after the first container is cut and opened are also received. The images are analyzed and, based upon the analysis, selective modifications to the operating parameters of the container opening machine are determined and made.

Abstract: A system and method for detecting hazardous items in a recycling facility, including: receiving, from a first non-visible spectrum image capturing device, a first non-visible spectrum image of items on a conveyor belt. The system and method may include providing, to an AI module, the first non-visible spectrum image of the items on the conveyor belt, where the AI module includes functionality to identify features of the items captured in the first non-visible spectrum image; compare the identified features of the items on the conveyor belt to features of hazardous items of the AI module; and identify a hazardous item in the first non-visible spectrum image based on a similarity between the identified features to the features of hazardous items of the AI module. The system and method may include providing, in response to identifying the hazardous item, an indication of the presence of the hazardous item.

Abstract: Systems, methods, and apparatuses are described herein for predicting resource shortages using machine learning.

Abstract: The system of the present disclosure reduces the temperature of any air conditioning condenser/radiator, either through retrofit or by original manufacturing. The system is connected to a water supply for pre-cooling ambient air drawn into the air conditioning unit by providing a misting spray of water that evaporates rapidly to cool the air conditioning condenser. The system has a water supply connection connected to the water supply, a water treatment assembly for treating aspects of the water supplied, and a water delivery assembly that receives clean water from the water treatment assembly and delivers the misting spray proximate the air conditioning unit. The system may be controlled by using a wireless technology such as a Z-wave or other type of wireless controller and one or more sensors.

Abstract: The contents of totes and the amount a tote container is filled are monitored. A central database stores product dimensions and tote dimensions as well as a percentage of which a tote is to be filled. Image scanners that obtain three-dimensional images are used to determine if the actual dimensions of the tote, the product, and the fill amount are consistent with the expected or optimal values of these characteristics. When there is a discrepancy between measured and expected values, then one or more actions can be taken.

Abstract: Examples provide a system and method for autonomously placing items into non-rigid containers. An image analysis component analyzes image data generated by one or more cameras associated with picked items ready for bagging and/or a non-rigid container, such as, but not limited to, a bag. The image analysis component generates dynamic placement data identifying how much space is available inside the bag, bag tension, and/or contents of the bag. A dynamic placement component generates a per-item assigned placement for a selected item ready for bagging based on a per-bag placement sequence and the dynamic placement data. Instructions, including the per-item assigned placement designating a location within the interior of the non-rigid container to the selected item and an orientation for the selected item after bagging, is sent to at least one robotic device. The robotic device places the selected item into the non-rigid container in accordance with the instructions.

Abstract: The contents of totes and the amount a tote container is filled are monitored. A central database stores product dimensions and tote dimensions as well as a percentage of which a tote is to be filled. Image scanners that obtain three-dimensional images are used to determine if the actual dimensions of the tote, the product, and the fill amount are consistent with the expected or optimal values of these characteristics. When there is a discrepancy between measured and expected values, then one or more actions can be taken.