Abstract: Provided is a method including providing a first audio content object that includes a plurality of audio content segments to a set of user computing devices. Each audio content segment of the plurality of audio content segments is associated with a first version. The method also includes obtaining a second version of a first audio content segment and updating the first version of the first audio content segment to the second version to generate a second audio content object that includes the second version of the first audio content segment and at least a first version of a second audio content segment. The method also includes providing the second audio content object to at least a first portion of the set of user computing devices and indicating a version history of the first audio content segment to at least the first portion of the set of user computing devices.

Abstract: Provided herein are materials and methods for plasma-based multiplexed labeling of biological molecules. In some aspects, provided herein is an optimized method for simultaneous labeling of proteins with trifluoromethyl, nitro, and hydroxyl radicals generated by a plasma in a single reaction vial, such as for protein footprinting.

Abstract: An SMA haptic assembly comprises relatively movable first and second parts and a length of SMA wire, the ends of which are connected to the first part or second part, wherein the first and second parts comprise at least one contact portion making contact with the length of SMA wire on opposite sides of the length of SMA wire and relatively positioned so as to guide the length of SMA wire along a tortuous path such that the first and second parts are driven in opposite directions along a movement axis on contraction of the length of SMA wire. The at least one contact portion of one or both of the first and second parts is formed from sheet material that is shaped to guide the path of the SMA wire in contact therewith, thereby reducing the overall thickness and simplifying manufacture.

Abstract: Methods and systems for providing a cold plate assembly include providing a base and a cover. The cover can be fixedly coupled to the base. Each of the base and the cover can include spaced internal ribs, which can form flow paths when the base and cover are fixedly coupled together. The internal ribs of the base and the cover can have spaced tabs that can be fixedly coupled to the other of the base or the cover. The base and the cover may also include spaced external or outer sacrificial ribs.

Abstract: Provided are mechanisms that allow automatic media content layering. The systems and methods obtain a media content list that includes a plurality of different types of media content segment entries. Media content tracks are determined from the plurality of media content segment entries and are based on the type of those entries. Media content track features are determined from the media content segment entries where those features are used to adjust the media content tracks, layering of multiple media content tracks, adjusting media content segments that make up the media content tracks or other features. A media content layered object is then generated based on the media content track features and the media content tracks. An action, such as storage, may be performed on the generated media content layered object.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria and design objectives associated with the urban design project and then generates numerous candidate designs that meet the design criteria and optimize the design objectives to varying degrees. The evaluation engine evaluates each candidate design to generate a set of metrics. The geometry engine modifies the candidate designs based on corresponding metrics to generate candidate designs that better meet the design criteria and more effectively achieve the design objectives.

Abstract: The disclosure describes devices and systems for a seal, and methods for using said seal. A seal includes a base portion configured to couple to a groove formed by a first surface of a first component. The base portion includes a notch in a bottom side of the base portion configured to cause the base portion to laterally flex responsive to an installation force. The seal further includes a sealing portion extending from the base portion. The sealing portion is configured to create an airtight seal between the first component and a sealing surface of a second component responsive to an application of a threshold sealing force against the sealing portion.

Abstract: An urban design pipeline is configured to automatically generate design options that meet competing design objectives. A geometry engine within the urban design pipeline generates candidate designs for an urban design project. An evaluation engine within the urban design pipeline evaluates the degree to which each candidate design addresses the competing design objectives to produce a set of design metrics. A tradeoff engine within the urban design pipeline generates a design tradeoff space based on the candidate designs and corresponding design metrics. The tradeoff engine traverses the design tradeoff space based on performance modifications to adjust the degree to which the competing design objectives are addressed. The performance modifications can be obtained from any number of stakeholders in the urban design project.

Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.

Abstract: An actuator arrangement for use in a camera is disclosed. The camera comprises two or more camera elements including an image sensor and one or more optical elements for forming, or aiding forming of, an image of an object on the image sensor. The actuator arrangement comprises: a first part defining a first axis; a first actuator for providing a first type of movement of one or more of the camera elements relative to the first part; a second actuator for providing a second, different type of movement of one or more of the camera elements relative to the first part; a controller configured to (a) cause the first actuator to move one or more of the camera elements so as to provide a first optical image stabilisation (OIS) effect, and (b) cause the second actuator to move one or more of the camera elements so as to provide a second OIS effect. The first and second OIS effects combine to provide an overall OIS effect that is greater than either of the first and second OIS effects.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: Features are applied to a mathematical model to produce a cutting pattern for opening a container. The cutting pattern specifies which of one or more cutting tools is to be used and the location of where cuts are to be made on the container. The cutting pattern is sent to a container opening machine. The container opening machine is operated and the container cut and opened by the container opening machine according to the cutting pattern.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: The present disclosure provides compositions of effector proteins. The compositions may comprise engineered guide nucleic acids. Also disclosed are the methods and systems for detecting and modifying target nucleic acids using the same. The compositions may provide nucleic acid modification and/or detection at relatively high temperatures.

Abstract: Power generation assemblies and methods relating thereto are disclosed. In an embodiment, the power generation assembly includes a thermoelectric generator, and a conductor configured to conduct electricity generated by the thermoelectric generator to the surface of a subterranean wellbore. The power generation assembly is to circulate a working fluid through a closed loop in the power generation assembly in response to the receipt of geothermal energy within a subterranean formation, to cause the thermoelectric generator to generate electricity.

Abstract: A shape memory alloy actuator (1) includes a first part (2), a second part (3), one or more heat sinks (2, 3, 35, 52), and one or more shape memory alloy wires (4, 5). The one or more shape memory alloy wires (4, 5) include a first segment of shape memory alloy wire (4). The one or more shape memory alloy wires (4, 5) are configured to move the second part (3) relative to the first part (2) over a range of movement. The first segment (4) of shape memory alloy wire is connected to the first part (2) by a first resilient element (7) at a first end (6), and a second end (8) of the first segment of shape memory alloy wire (4) is connected to the second part (3).

Abstract: An actuator assembly (4001) includes a first part (4002), a second part (4004), a bearing arrangement (4003) and a drive arrangement (4005). The bearing arrangement (4003) includes first to fourth flexures (40151, 40152, 40153, 40154) arranged about a primary axis (4009) passing through the actuator assembly (4001). The bearing arrangement (4003) supports the second part (4004) on the first part (4002). The second part (4004) is tiltable about first and/or second axes (4011, 4012) which are not parallel and which are perpendicular to the primary axis (4009). The drive arrangement (4005) includes four lengths of shape memory alloy wire (40101, 40102, 40103, 40104). The four lengths of shape memory alloy wire (40101, 40102, 40103, 40104) are coupled to the second part (4004) and to the first part (4002).

Abstract: A parent tote container is segmented into smaller, child tote containers. Each of the child tote containers includes products that are commonly sold together and are removed from the tote containers at picker stations with the same type of picker mechanism. Items are moved from the child tote containers to a customer order tote container at a picker station.

Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.