Abstract: A therapeutic agent delivery system includes a catheter, a vascular occluder, a pressure sensor system, and a pump system. The vascular occluder is provided at the distal end of the catheter. The pressure sensor system is provided to sense pressure at the distal end of a catheter lumen, and provides feedback to the pump system. The pump system is adapted to control the rate of infusion of the therapeutic agent through the lumen of the catheter based on the pressure sensed by the pressure sensor system. A method includes deploying the occluder in a vessel, and then sensing a pressure in the vessel. The therapeutic agent is infused into the vessel at a flow rate based on the sensed pressure.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Methods, systems, and computer-readable storage media for providing footprints in a computer system that provides a virtual environment, including: accessing an avatar record, where the avatar record indicates an avatar representation that includes data to provide a visual representation of an avatar; receiving a selection of a footprint; accessing a footprint record, where the footprint record includes footprint representations that include data to provide a visual representation of the selected footprint as a footprint representation; associating the footprint representation with the avatar representation; receiving avatar movement input that indicates movement of the avatar within the virtual environment; and generating visual data representing the movement of the avatar and footprints in the virtual environment using the avatar representation and the footprint representation, where the footprints are placed in the virtual environment following the avatar as the avatar moves in the virtual environment.

Abstract: The contents of totes and the amount a tote container is filled are monitored. A central database stores product dimensions and tote dimensions as well as a percentage of which a tote is to be filled. Image scanners that obtain three-dimensional images are used to determine if the actual dimensions of the tote, the product, and the fill amount are consistent with the expected or optimal values of these characteristics. When there is a discrepancy between measured and expected values, then one or more actions can be taken.

Abstract: A solution for automated food selection includes: an order processing component operable to receive an order identifying an item; a selection component comprising: a first hyperspectral sensor operable to sense a reflection from the item and produce a sensor output based at least on the reflection; and a picking mechanism; a control component operable to: based at least on identification of the item, select a hyperspectral profile from a set of hyperspectral profiles; compare the sensor output with the selected hyperspectral profile; and based at least on the comparison, determine whether to select the item for fulfillment of the order, wherein the picking mechanism is operable to divert the item to a selection output based at least on a determination to select the item for fulfillment of the order; and a transport component operable to transport the item to an order storage zone.

Abstract: Provided herein, in certain embodiments, are various methods, reagents, and devices for detection of multiple target nucleic acids in a sample, or multiple segments of a target nucleic acid in a sample, using a programmable nuclease. In certain embodiments, the present disclosure provides compositions of pools of guide nucleic acids, programmable nucleases, and detector nucleic acids and methods of using said compositions for detection of different segments of one target nucleic acid or different target nucleic acids in a sample.

Abstract: Embodiments for a metadata predictor. An index pipeline generates indices in an index buffer in which the indices are used for reading out a memory device. A prediction cache is populated with metadata of instructions read from the memory device. A prediction pipeline generates a prediction using the metadata of the instructions from the prediction cache, the populating of the prediction cache with the metadata of the instructions being performed asynchronously to the operating of the prediction pipeline.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: An automated container cutting system includes a cutting tool configured to cut a container and a force feedback sensor operatively connected to the cutting tool. The force feedback sensor is configured to measure resistive force exerted on the cutting tool. The automated container cutting system includes a processor communicatively coupled to the force feedback sensor. The processor is configured to receive resistive force data from the force feedback sensor and determine whether the cutting tool has penetrated through the wall of the container using the received resistive force data.

Abstract: A syndesmotic reconstruction guide assembly is disclosed. The syndesmotic reconstruction guide assembly includes a medial arm, a medial foot, and a lateral arm. The medial foot is rotatably connected to the medial arm with at least one degree of freedom. The lateral arm is slidably connected to the medial arm at an end opposite the medial foot. The lateral arm includes a lateral foot. The medial foot and the lateral foot are adapted to clamp bones of a syndesmotic joint therebetween.

Abstract: First scanned images of the first container are received from a scanning device that show the contents of the interior of the first container before the first container is cut and opened. Second scanned images that are of the contents of the first container after the first container is cut and opened are also received. The images are analyzed and, based upon the analysis, selective modifications to the operating parameters of the container opening machine are determined and made.

Abstract: Examples provide an item storage cart for verifying correct item placement into containers on the item storage cart. A cart manager component outputs planogram data identifying a location of a selected item. Weight data generated by one or more weight sensors associated with the set of item storage containers is analyzed to verify whether a correct item is placed in a given storage container on the cart and/or verify a selected item is placed into a correct storage container. The cart manager component determines if an unselected item is removed from a storage container and/or if an unselected item is added to a storage container. A notification is output if an incorrect item is added to a cart, an incorrect item is removed from the cart, an item is added to the wrong container or removed from the wrong container.

Abstract: Systems, apparatuses, and methods are described herein for generating structured data from unstructured data using natural language processing to generate a secure medical dashboard. The present invention is configured to identify at least one data input, wherein the at least one data input comprises unstructured data; apply at least one NLP pipeline to the at least one data input; parse the unstructured data to generate a parsed unstructured dataset; identify a medical relevance attribute; generate a structured document comprising the at least one term and associated medical relevance attribute; correlate the at least one term comprising the positive medical attribute to a medical entity title; generate a medical dashboard interface component comprising the at least one term comprising the positive medical attribute and the medical entity title; transmit the medical dashboard interface component to a user device; and generate a secure medical dashboard on the user device.

Abstract: A solution for automated food selection includes: an order processing component operable to receive an order identifying an item; a selection component comprising: a first hyperspectral sensor operable to sense a reflection from the item and produce a sensor output based at least on the reflection; and a picking mechanism; a control component operable to: based at least on identification of the item, select a hyperspectral profile from a set of hyperspectral profiles; compare the sensor output with the selected hyperspectral profile; and based at least on the comparison, determine whether to select the item for fulfillment of the order, wherein the picking mechanism is operable to divert the item to a selection output based at least on a determination to select the item for fulfillment of the order; and a transport component operable to transport the item to an order storage zone.

Abstract: An automated container cutting system for cutting a container includes a cutting platform and a cutting tool held by the cutting platform. The cutting tool is configured to cut the container. The automated container cutting system includes a force feedback sensor operatively connected to the cutting tool such that the force feedback sensor is configured to measure resistive force exerted on the cutting tool. The automated container cutting system includes at least one processor communicatively coupled to the force feedback sensor. The processor is configured to receive resistive force data from the force feedback sensor. The resistive force data represents resistive force exerted on the cutting tool as the cutting tool pierces a wall of the container. The at least one processor is configured to determine whether the cutting tool has penetrated through the wall of the container using the received resistive force data.

Abstract: First scanned images of the first container are received from a scanning device that show the contents of the interior of the first container before the first container is cut and opened. Second scanned images that are of the contents of the first container after the first container is cut and opened are also received. The images are analyzed and, based upon the analysis, selective modifications to the operating parameters of the container opening machine are determined and made.

Abstract: Features are applied to a mathematical model to produce a cutting pattern for opening a container. The cutting pattern specifies which of one or more cutting tools is to be used and the location of where cuts are to be made on the container. The cutting pattern is sent to a container opening machine. The container opening machine is operated and the container cut and opened by the container opening machine according to the cutting pattern.

Abstract: System and method enable rapid prototyping of an Internet of Things (IoT) device equipped with a modem. The system creates an abstraction layer subsuming a modem AT command set, where the abstraction layer provides a higher-level functionality than the modem AT command set. A function associated with the abstraction layer includes multiple function calls to the modem AT command set. The system can receive an input indicating an instruction to initiate a connection between the modem and a telecommunication network. The system can invoke a particular function associated with the abstraction layer to establish the connection between the modem and the telecommunication network.

Abstract: First scanned images of the first container are received from a scanning device that show the contents of the interior of the first container before the first container is cut and opened. Second scanned images that are of the contents of the first container after the first container is cut and opened are also received. The images are analyzed and, based upon the analysis, selective modifications to the operating parameters of the container opening machine are determined and made.