Abstract: A method of manufacturing a connector for a fluid transfer conduit comprises: manufacturing a tube which runs parallel to a central axis C from fibre-reinforced polymer, said tube comprising a hub portion 206 and a flange-forming portion 208 located adjacent to the hub portion 206, wherein the hub portion 206 comprises continuous circumferentially oriented fibre-reinforcement 210; and the hub portion 206 and the flange-forming portion 208 comprise longitudinally oriented fibre-reinforcement 212 which runs continuously from the hub portion 206 into the flange-forming portion 208; and bending the flange-forming portion 208 away from the central axis C such that it extends from the hub portion 206 at an angle to the central axis C.

Abstract: This invention is an apparatus to produce electrical power from the wearer's respiration through the application of a circular cluster of Variable Reluctance sensors that are excited by a rotating disk holding a plurality of magnets arranged radially, on its face, and spaced uniformly about its circumference. The sensors' arrangement conforms to the circumference and are perpendicular to the face of the rotating disk. This arrangement produces corresponding sinusoidal voltages that are each converted to DC via a corresponding rectifier circuit. The resulting DC voltage outputs are then summed to produce a single power output, which is fed to a DC-to-DC converter. The rotating disk's unidirectional motion is produced by a ratchet gear system attached to a partially elastic torso garment, which is worn on the mid torso. The ratchet gear system moves proportionally, in response to the reciprocal motion of a wearer's respiration.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: A composite shaft with an end fitting mounted on an interface region on at least one end of said shaft, and a preload structure arranged to provide a biasing force to bias the composite shaft against the end fitting; wherein the preload structure is in an interference fit with the composite shaft. The preload structure is applied to the composite shaft in a subsequent operation to the mounting of the end fitting to the shaft.

Abstract: A fiber reinforced polymer composite pipe includes first and second ends and defines a central axis running in a longitudinal direction from the first end to the second end, and the pipe including at least one non-linear portion along the central axis between the first end and the second end. A first material extends continuously from the first end to the second end, the first material being a fiber reinforced polymer material comprising fiber reinforcement in a polymer matrix and having an electrical resistivity determined by an electrically conductive fiber reinforcement and/or an electrically conductive additive in the polymer matrix; and a second material arranged at the at least one non-linear portion and extending discontinuously between the first end and the second end, and has an elastic modulus greater than the elastic modulus of the first material in the longitudinal direction.

Abstract: A composite shaft with an end fitting mounted on an interface region on at least one end of said shaft, and a preload structure arranged to provide a biasing force to bias the composite shaft against the end fitting; wherein the preload structure is in an interference fit with the composite shaft. The preload structure is applied to the composite shaft in a subsequent operation to the mounting of the end fitting to the shaft.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: A fiber reinforced polymer composite pipe includes first and second ends and defines a central axis running in a longitudinal direction from the first end to the second end, and the pipe including at least one non-linear portion along the central axis between the first end and the second end. A first material extends continuously from the first end to the second end, the first material being a fiber reinforced polymer material comprising fiber reinforcement in a polymer matrix and having an electrical resistivity determined by an electrically conductive fiber reinforcement and/or an electrically conductive additive in the polymer matrix; and a second material arranged at the at least one non-linear portion and extending discontinuously between the first end and the second end, and has an elastic modulus greater than the elastic modulus of the first material in the longitudinal direction.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: Time-series data and domain knowledge rules governing interpretation of the time-series data in building a semiotic model of a user are accessed. An experience event is extracted from the time-series data based on the rules. A triadic data structure is generated based on the event to include an object element, a sign element, and an interpretant element. The interpretant element is determined based on an observation associated with the rules. An object of interest that appears in the environment of the user during the experience event is identified based on the time-series data. The object element of the triadic data structure is determined based on the object of interest. The triadic data structure is added to the semiotic model as a hypothesis. Once validated, the triadic data structure represents an interpretive habit of the user.

Abstract: Provided herein are agents, such as antibodies and chimeric antigen receptors, that target HSP70. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an HSP70-targeting agent. The HSP70-specific antibody may enhance uptake of HSP70 by antigen presenting cells.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: A composite tubular structure includes an elongate composite member having an inwardly tapered section at an end and an embedded nut retained in the end inwardly tapered section for forming a connection with another component. The inwardly tapered section has an inner surface which follows a tapered outer surface of the embedded nut, the inwardly tapered section narrowing the composite member in a longitudinal direction towards the end so as to provide a constriction which retains the embedded nut within the inwardly tapered section. The embedded nut comprises a multipart nut, comprising an internal nut and an internal support member, and wherein the internal nut is arranged to slide within the internal support member in a direction away from the end of, and into, the elongate composite member when the composite tubular structure is under conditions of excessive axial compressive load.

Abstract: A solventless system for fabricating electrodes includes a mechanism for feeding a substrate through the system, a first application region comprised of a first device for applying a first layer to the substrate, wherein the first layer is comprised of an active material mixture and a binder, and the binder includes at least one of a thermoplastic material and a thermoset material, and the system includes a first heater positioned to heat the first layer.