Patents by Inventor James A. Bianco

James A. Bianco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080146598
    Abstract: The present invention discloses combinations of drug conjugates with other therapeutic agents, including chemotherapy drugs. The invention also provides methods of using the combinations for the treatment of diseases associated with cell proliferation, such as tumors.
    Type: Application
    Filed: February 22, 2008
    Publication date: June 19, 2008
    Applicant: Cell Therapeutics, Inc.
    Inventor: James A. Bianco
  • Publication number: 20040047835
    Abstract: The present invention discloses combinations of drug conjugates with other therapeutic agents, including chemotherapy drugs. The invention also provides methods of using the combinations for the treatment of diseases associated with cell proliferation, such as tumors.
    Type: Application
    Filed: August 6, 2003
    Publication date: March 11, 2004
    Applicant: Cell Therapeutics, Inc.
    Inventor: James A. Bianco
  • Patent number: 6420374
    Abstract: A family of compounds effective in suppressing lymphocyte activation is comprised of 7-(oxoalkyl)1,3-dialkyl xanthines, other than denbufylline, of the formula in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: July 16, 2002
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: James A. Bianco, Jack W. Singer, William J. Novick, Jr.
  • Patent number: 5965564
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: October 12, 1999
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5856115
    Abstract: There is disclosed a method for screening for inhibitors of cellular second messenger signaling regulated by lysophosphatidic acid acyl transferase (LPAAT) and phosphatidic acid phosphohydrolase (PAPH), which method comprises contacting target cells or appropriate subcullular elements under appropriate conditions of stimulation with a candidate drug and assessing the levels of the relevant subsets of phosphatidic acid (PA) and diacylglycerol (DAG) in the presence and absence of the candidate drug.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: January 5, 1999
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: James A. Bianco, Stuart L. Bursten, Jack W. Singer
  • Patent number: 5792772
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 11, 1998
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5739138
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 14, 1998
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5652243
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: July 29, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Jack Singer
  • Patent number: 5648357
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: July 15, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5629315
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: May 13, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5620984
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating inflammatory disease.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 15, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5621102
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 15, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5612349
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 18, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5585380
    Abstract: The specification discloses methods for modulating cellular metabolism in a subject, modulating being desirable to mitigate a condition of the subject. Disclosed methods include processes for administering to said subject an effective amount of a compound of the formula ##STR1## wherein one and only one of R.sup.1 and R.sup.3 is a straight-chain or branched-chain .omega.-hydroxyalkyl (5-8C), or is a branched-chain (.omega.-1)-hydroxyalkyl (5-8C), or is an (.omega.-1)-oxoalkyl (5-8C), or is an (.omega., .omega.-1) or (.omega.-1, .omega.-2)-dihydroxyalkyl (5-8C), or is an alkenyl substituent (5-8C), and the other is alkyl (1-12C) optionally containing one or two non-adjacent oxygen atoms in place of C.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: December 17, 1996
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: James A. Bianco, Stuart L. Bursten, Jack W. Singer
  • Patent number: 5580873
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating proliferative vascular disease.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: December 3, 1996
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5580874
    Abstract: Them is disclosed compounds and pharmaceutical compositions that is R enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating the side effects of immunosuppressive agent and interleukin-2 therapy.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: December 3, 1996
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer
  • Patent number: 5567704
    Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating baldness.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 22, 1996
    Assignee: Cell Therapeutics, Inc.
    Inventors: James A. Bianco, Paul Woodson, David Porubek, Jack Singer