Patents by Inventor James A. Bonini
James A. Bonini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7416848Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.Type: GrantFiled: October 22, 2002Date of Patent: August 26, 2008Assignee: H. Lundbeck A/SInventors: James A. Bonini, Beth E. Borowsky, Nika Adham, Noel Boyle, Thelma O. Thompson
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Patent number: 7276339Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: GrantFiled: November 18, 2004Date of Patent: October 2, 2007Assignee: H. Lundbeck A/SInventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
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Patent number: 7252945Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: GrantFiled: November 18, 2004Date of Patent: August 7, 2007Assignee: H. Lundbeck A/SInventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
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Patent number: 7041461Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: GrantFiled: May 25, 2001Date of Patent: May 9, 2006Assignee: H. Lundbeck A/SInventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth Borowsky
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Patent number: 7029857Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF62 and SNORF72 receptors, purified mammalian SNORF62 and SNORF72 receptors, vectors comprising nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF62 and SNORF72 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF62 and SNORF72 receptors, methods of isolating mammalian SNORF62 and SNORF72 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF62 and SNORF72 receptors, as well as methods of determining binding of compounds to mammalian SNORF62 and SNORF72 receptors, methods of identifying agonists and antagonists of SNORF62 and SNORF72 receptorsType: GrantFiled: June 30, 2000Date of Patent: April 18, 2006Assignee: H. Lundbeck A/SInventors: James A. Bonini, Gabriel S. Lerman, Kristine L. Ogozalek, Yong Quan
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Publication number: 20050260687Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: ApplicationFiled: November 18, 2004Publication date: November 24, 2005Inventors: Christophe Gerald, Kenneth Jones, James Bonini, Beth Borowsky, Douglas Craig
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Publication number: 20050089937Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: ApplicationFiled: November 18, 2004Publication date: April 28, 2005Inventors: Christophe Gerald, Kenneth Jones, James Bonini, Beth Borowsky, Douglas Craig
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Patent number: 6849727Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: GrantFiled: March 29, 2000Date of Patent: February 1, 2005Assignee: H.Lundbeck A/SInventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
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Patent number: 6709831Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: GrantFiled: September 24, 1999Date of Patent: March 23, 2004Assignee: Synaptic Pharmaceutical CorporationInventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
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Publication number: 20030176685Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF7 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to (a) a nucleic acid encoding a human SNORF7 receptor and having a sequence comprising the sequence of the human SNORF7 nucleic acid contained in plasmid pCR2.1-hSNORF7-p (ATCC Accession No. 203778), (b) a nucleic acid encoding a rat SNORF7 receptor and having a sequence identical to the sequence of the rat SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T7-rSNORF7-f (ATCC Accession No. 203777), or (c) nucleic acid encoding a human SNORF7 receptor and having a sequence identical to the sequence of the human SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T73BS-hSNORF7-f ATCC Patent Depository No. PTA-426).Type: ApplicationFiled: May 7, 2002Publication date: September 18, 2003Inventors: Beth E. Borowsky, Hla Kyaw, James A. Bonini
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Publication number: 20030158401Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF13 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF13 receptor and having a sequence identical to the sequence of either one of the human SNORF13a receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7hSNORF13a-f (Patent Deposit Designation No. PTA-______), the human SNORF13b receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13b-f (Patent Deposit Designation No. PTA-______), the human SNORF13c receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13c-f (Patent Deposit Designation No. PTA-______), or the human SNORF13d receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13d-f (Patent Deposit Designation No.Type: ApplicationFiled: October 21, 2002Publication date: August 21, 2003Inventors: Marie Sudam Pathirana, Kristine L. Ogozalek, Beth E. Borowsky, James A. Bonini, Kelli E. Smith
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Publication number: 20030143670Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF44 receptor, purified mammalian SNORF44 receptor, vectors comprising nucleic acid encoding mammalian SNORF44 receptor, cells comprising such vectors, antibodies directed to mammalian SNORF44 receptor, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF44 receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF44 receptor, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF44 receptor, and methods of isolating mammalian SNORF44 receptor. This invention also provides methods of treating an abnormality that is linked to the activity of a mammalian SNORF44 receptor, as well as methods of determining binding of compounds to a mammalian SNORF44 receptor, methods of identifying agonists and antagonists of a SNORF44 receptor, and agonists and antagonists so identified.Type: ApplicationFiled: February 20, 2002Publication date: July 31, 2003Inventors: James A. Bonini, Ling-Yan Huang, Amy E. Wilson
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Publication number: 20030139590Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.Type: ApplicationFiled: October 22, 2002Publication date: July 24, 2003Applicant: Synaptic Pharmaceutical CorporationInventors: James A. Bonini, Beth E. Borowsky, Nika Adham, Noel Boyle, Thelma O. Thompson
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Publication number: 20030130493Abstract: This invention provides isolated nucleic acids encoding mammalian Edg7 receptors, purified mammalian Edg7 receptors, vectors comprising nucleic acid encoding mammalian Edg7 receptors, cells comprising such vectors, antibodies directed to mammalian Edg7 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian Edg7 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian Edg7 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian Edg7 receptors, methods of isolating mammalian Edg7 receptors, methods of treating an abnormality that is linked to the activity of the mammalian Edg7 receptors, as well as methods of determining binding of compounds to mammalian Edg7 receptors, methods of identifying agonists and antagonists of Edg7 receptors, and agonists and antagonists so identified.Type: ApplicationFiled: August 26, 2002Publication date: July 10, 2003Inventors: James A. Bonini, Ling Yan Huang, Beth E. Borowsky, John A. Salon, Amy Wilson, Raisa Nagorny
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Publication number: 20030125539Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.Type: ApplicationFiled: October 22, 2002Publication date: July 3, 2003Applicant: Synaptic Pharmaceutical CorporationInventors: James A. Bonini, Beth E. Borowsky, Nika Adham, Noel Boyle, Thelma O. Thompson
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Publication number: 20030109695Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF7 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to (a) a nucleic acid encoding a human SNORF7 receptor and having a sequence comprising the sequence of the human SNORF7 nucleic acid contained in plasmid pCR2.1-hSNORF7-p (ATCC Accession No. 203778), (b) a nucleic acid encoding a rat SNORF7 receptor and having a sequence identical to the sequence of the rat SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T7-rSNORF7-f (ATCC Accession No. 203777), or (c) nucleic acid encoding a human SNORF7 receptor and having a sequence identical to the sequence of the human SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T73BS-hSNORF7-f ATCC Patent Depository No. PTA-426).Type: ApplicationFiled: November 6, 2002Publication date: June 12, 2003Inventors: Beth E. Borowsky, Hla Kyaw, James A. Bonini
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Publication number: 20030104534Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF42 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF42 receptor and having a sequence identical to the sequence of the human SNORF42 receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF42-f (Patent Deposit Designation No. PTA ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF42 receptor, wherein the human SNORF42 receptor comprises an amino acid sequence identical to the sequence of the human SNORF42 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (SEQ ID NO: 1).Type: ApplicationFiled: May 6, 2002Publication date: June 5, 2003Inventors: James A. Bonini, Marie Sudam Pathirana
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Publication number: 20030083488Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF66 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF66 receptor and having a sequence identical to the sequence of the human SNORF66 receptor-encoding nucleic acid contained in plasmid pcDNA3.1-hSNORF66-f (Patent Deposit Designation No. PTA ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF66 receptor, wherein the human SNORF66 receptor comprises an amino acid sequence identical to the sequence of the human SNORF66 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (SEQ ID NO: 1).Type: ApplicationFiled: December 2, 2002Publication date: May 1, 2003Applicant: Synaptic Pharmaceutical CorporationInventors: Beth E. Borowsky, James A. Bonini, Christophe Gerald
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Publication number: 20030078408Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF43 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF43 receptor and having a sequence identical to the sequence of the human SNORF43 receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF43-f (Patent Deposit Designation No. PTA______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF43 receptor, wherein the human SNORF43 receptor comprises an amino acid sequence identical to the sequence of the human SNORF43 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (SEQ ID NO: 1).Type: ApplicationFiled: September 6, 2002Publication date: April 24, 2003Inventors: Marie Sudam Pathirana, James A. Bonini
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Publication number: 20020198367Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: ApplicationFiled: May 25, 2001Publication date: December 26, 2002Applicant: Synaptic Pharmaceutical CorporationInventors: Christophe P.G. Gerald, Kenneth A. Jones, James A. Bonini, Beth Borowsky