Patents by Inventor James A. Bowen
James A. Bowen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108061Abstract: Systems and methods to generate an inhalable vapor in an electronic vaporization device. Described herein are cartridges including a vaporizable material that may be securely connected to a rechargeable base unit.Type: ApplicationFiled: September 11, 2023Publication date: April 4, 2024Inventors: Adam Bowen, Steven Christensen, Christopher Nicholas HibmaCronan, James Monsees, Joshua Morenstein
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Publication number: 20240108831Abstract: Provided herein are systems and methods to generate an inhalable vapor in an electronic vaporization device. The vaporization device may generate a vapor with one or more defined characteristics. In some cases, the vapor may have a predetermined aerosol number density and/or a predetermined average aerosol diameter. The vaporization device may generate a vapor from a vaporizable material. In some cases, the vaporizable material may be a liquid material housed in a cartridge. The vaporization device may comprise a rechargeable power storage device.Type: ApplicationFiled: September 11, 2023Publication date: April 4, 2024Inventors: Ariel Atkins, Adam Bowen, Steven Christensen, Nicholas Jay Hatton, Christopher Nicholas HibmaCronan, James Monsees, Joshua Morenstein
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Patent number: 11596472Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.Type: GrantFiled: May 21, 2020Date of Patent: March 7, 2023Assignee: 460Medical, Inc.Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen
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Patent number: 11559352Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: GrantFiled: May 21, 2020Date of Patent: January 24, 2023Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 11458243Abstract: A medical device is provided for irrigation of a patient wound site. The device contains a tube having a proximal portion adapted to receive an irrigation solution, a distal portion having a nozzle and an intermediate portion for transporting the solution. The tube has a barrel portion that may be manipulated by a user to position the device relative to the wound site. A distinctive nozzle has a body formed with a distally leading channel presenting a semispherical first spatial conformation and a proximally leading opening formed in the body presenting a second spatial conformation intersecting the semispherical terminus. This geometry, derived from principles of flow mechanics discussed herein, defines what will be described as an “effective diameter” of the nozzle. An assembly and system utilizing the device am also disclosed. The invention utilizes a fluid-isolating durable peristaltic pump for a continuous flow of irrigation solution, along with a single use tube set that embodies the device.Type: GrantFiled: April 28, 2022Date of Patent: October 4, 2022Inventors: James Bowen Stiehl, Kurt R. Stiehl
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Publication number: 20220265916Abstract: A medical device is provided for irrigation of a patient wound site. The device contains a tube having a proximal portion adapted to receive an irrigation solution, a distal portion having a nozzle and an intermediate portion for transporting the solution. The tube has a barrel portion that may be manipulated by a user to position the device relative to the wound site. A distinctive nozzle has a body formed with a distally leading channel presenting a semispherical first spatial conformation and a proximally leading opening formed in the body presenting a second spatial conformation intersecting the semispherical terminus. This geometry, derived from principles of flow mechanics discussed herein, defines what will be described as an “effective diameter” of the nozzle. An assembly and system utilizing the device am also disclosed. The invention utilizes a fluid-isolating durable peristaltic pump for a continuous flow of irrigation solution, along with a single use tube set that embodies the device.Type: ApplicationFiled: April 28, 2022Publication date: August 25, 2022Inventors: James Bowen Stiehl, Kurt R. Stiehl
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Publication number: 20220185889Abstract: Compositions and methods for pharmacodynamic monitoring of immunotherapy are provided herein. The compositions include an immunotherapeutic agent linked to protease substrates. Upon administration, the compositions target to sites of disease where proteases are upregulated during responsive immunotherapy and subsequently cleave the attached substrates. Cleavage fragments are detected in a sample from the body and detection of the fragments is indicative of an effect of the immunotherapeutic agent.Type: ApplicationFiled: September 11, 2019Publication date: June 16, 2022Inventors: James Bowen, Gabriel Kwong, Quoc Mac
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Patent number: 11351296Abstract: A medical device is provided for irrigation of a patient wound site. The device contains a tube having a proximal portion adapted to receive an irrigation solution, a distal portion having a nozzle and an intermediate portion for transporting the solution. The tube has a barrel portion that may be manipulated by a user to position the device relative to the wound site. A distinctive nozzle has a body formed with a distally leading channel presenting a semispherical first spatial conformation and a proximally leading opening formed in the body presenting a second spatial conformation intersecting the semispherical terminus. This geometry, derived from principles of flow mechanics discussed herein, defines what will be described as an “effective diameter” of the nozzle. An assembly and system utilizing the device are also disclosed. The invention utilizes a fluid-isolating durable peristaltic pump for a continuous flow of irrigation solution, along with a single use tube set that embodies the device.Type: GrantFiled: October 5, 2018Date of Patent: June 7, 2022Inventors: James Bowen Stiehl, Kurt R. Stiehl
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Publication number: 20220120679Abstract: A system and method for self-calibrating optical turbidity measurements includes a housing comprising a cavity with an inner wall having an essentially straight section and an opening for the medium. An optical standard is moveable between first and second sections within the essentially straight section, and a light source and a light sensor, arranged at the first section and configured to measure the turbidity of the medium, when the optical standard is at the second section, and configured to measure the turbidity of the optical standard and to determine, as a function of the measured turbidity, a calibration coefficient for performing a self-calibration, when the optical standard is at the first section.Type: ApplicationFiled: December 30, 2021Publication date: April 21, 2022Applicant: ABB Schweiz AGInventors: Benjamin Carr, Andrew James Bowen
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Publication number: 20210391066Abstract: The procedure and surgical information alert system 10 is a surgical management system for capturing, storing, processing, tracking, and sharing patient and procedural identification data, including implant data, during medical/surgical procedures performed at multiple medical offices 20 and/or surgical center 30 locations. The procedure and surgical information alert system 10 allows for accurate verification of the predetermined procedure verified between the physician and patient during the scheduling process at a medical office 20, which is confirmed at that time by the patient's signature. On the day of the surgical procedure, the patient information is re-verified by the patient at a surgery center. Prior to the surgical procedure, a time-out alert warning 240 is generated to freeze use of the system until physician verification of the patient information is confirmed. Implant inventory alert warnings 192 are provided to authorized surgery center staff based on predictive implant inventory needs.Type: ApplicationFiled: June 15, 2021Publication date: December 16, 2021Applicant: Buckingham Holdings, LLCInventors: Gregory A. Eippert, James Bowens
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Publication number: 20210333283Abstract: An activity sensor sensitive to enzymes indicative of the presence of cancer is used to provide non-invasive reporting of tumor development and response to anticancer therapies useful in determining suitability and effectiveness of various treatments including immuno-oncological therapies. Localized reporters are used in patient stratification in clinical trials, monitoring of drug response or disease progression, and differentiating between anti-tumor immune response, tumor progression, and off-target immune response. Activity sensors may include tuning domains to modulate tissue localization and residency. Periodic measurements of activity sensor reporters may be analyzed to determine a velocity value indicative of disease prognosis.Type: ApplicationFiled: April 23, 2021Publication date: October 28, 2021Inventors: James Bowen, Faycal Touti
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Publication number: 20210333286Abstract: An activity sensor sensitive to enzymes indicative of tissue condition are co-administered with control or normalizing activity sensors providing levels of the same enzyme in other tissues or levels of control enzymes indicative of assay success. Levels of control reporters can be used to normalize activity sensor data across samples such as in analyte velocity analyses. Control reporters can also be used to differentiate localized enzyme activity from systemic activity and to confirm activity sensor localization or to troubleshoot activity sensor uptake problems. Activity sensors and controls sensitive to immunological enzymes are particularly useful in assessing immuno-oncology treatments.Type: ApplicationFiled: April 23, 2021Publication date: October 28, 2021Inventors: James Bowen, Faycal Touti
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Publication number: 20210330218Abstract: Data from activity sensors sensitive to enzymes indicative of various disease states is combined with data from other sources including electronic medical records and clinical data including molecular diagnostic testing. The pooled data can be analyzed to identify patterns indicative of certain outcomes including development of a disease, progression of a disease, or likely therapeutic efficacy of a given treatment for a patient.Type: ApplicationFiled: April 23, 2021Publication date: October 28, 2021Inventors: James Bowen, Faycal Touti
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Publication number: 20210227952Abstract: A wound care kit is disclosed. The wound care kit includes a rotary brush configured to engage a wound; a fluid delivery device configured to deliver fluid to the wound, and a control unit configured to control the spin rate of the rotary brush.Type: ApplicationFiled: January 26, 2021Publication date: July 29, 2021Inventors: James Bowen Stiehl, Kurt R. Stiehl
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Publication number: 20200352645Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: ApplicationFiled: May 21, 2020Publication date: November 12, 2020Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Publication number: 20200352644Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.Type: ApplicationFiled: May 21, 2020Publication date: November 12, 2020Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen
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Publication number: 20200261641Abstract: A medical device is provided for irrigation of a patient wound site. The device contains a tube having a proximal portion adapted to receive an irrigation solution, a distal portion having a nozzle and an intermediate portion for transporting the solution. The tube has a barrel portion that may be manipulated by a user to position the device relative to the wound site. A distinctive nozzle has a body formed with a distally leading channel presenting a semispherical first spatial conformation and a proximally leading opening formed in the body presenting a second spatial conformation intersecting the semispherical terminus. This geometry, derived from principles of flow mechanics discussed herein, defines what will be described as an “effective diameter” of the nozzle. An assembly and system utilizing the device are also disclosed. The invention utilizes a fluid-isolating durable peristaltic pump for a continuous flow of irrigation solution, along with a single use tube set that embodies the device.Type: ApplicationFiled: October 5, 2018Publication date: August 20, 2020Inventors: James Bowen Stiehl, Kurt R. Stiehl
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Patent number: 10722301Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.Type: GrantFiled: November 3, 2015Date of Patent: July 28, 2020Assignees: The George Washington University, 460Medical, Inc.Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
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Patent number: 10682179Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.Type: GrantFiled: October 23, 2018Date of Patent: June 16, 2020Assignee: 460Medical, Inc.Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen
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Patent number: D861860Type: GrantFiled: November 15, 2017Date of Patent: October 1, 2019Inventor: James Bowen Stiehl