Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

Abstract: A computer-implemented method for identifying recurrent causal sequences in datasets is provided. The method comprises receiving at least first and second datasets each comprising a plurality of data points and computing a degree of causal relatedness for all pairs of the data points of the first and second datasets. The method comprises constructing first and second directed acyclic graphs on top of the respective first and second datasets. The method comprises constructing a second order graph using the first and the second directed acyclic graphs and identifying recurrent sequences of patterns in the first and second directed acyclic graphs based on the second order graph.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Methods, systems, and apparatuses are described for identifying potential identity fraud by tracking a user's typical communication patterns. If a new communication is received from someone who purports to be a trusted user, but the communication exhibits communication traits that are not typical for the user, additional identity fraud prevention steps may be taken.

Abstract: Solving a discrete optimization problem in a neuromorphic device is provided. A number of random noise generators are connected to a number of leaky integrate and fire (LIF) neurons. Weights are assigned to the connections between the random noise generators and the LIF neurons. The weights are chosen to produce a correlation matrix determined by the discrete optimization problem. The LIF neurons integrate random bits generated by the random noise generators according to the assigned weights to produce specified correlated activity variables. The correlated activity variables are fed to an output LIF neuron that operates according to a plasticity rule and outputs an approximate solution to the discrete optimization problem according to the correlated activity variables.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Systems and methods are provided for monitoring a plurality of chat messages. Values are extracted from multiple chat messages between a first party and a second party. Context is determined for the values and/or messages. The context is used to determine the relationship between the values, messages, and one or more transactions. Once all values of a transaction are identified, an order ticket is generated.

Abstract: Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.

Abstract: A method for probabilistic computing is provided. The method comprises specifying a target distribution for a computational model, wherein the target distribution is defined by a function. A number of coin flips are performed with a number of weighted coinflip devices, wherein weights for the coinflip devices are determined by the function. The number of coinflips are then converted to a random number from the target distribution according to outputs of the weighted coinflip devices, wherein a circuit uses the coin flips as inputs to randomly activate bits in a binary representation of the random number.

Abstract: Sampling an artificial neural network is provided. The method comprises creating a number of sample matrices based on a weight matrix of a trained artificial neural network, wherein each element in the sample matrices is equal to one of a pair of numbers generated by stochastic neuromorphic hardware according to weights from the weight matrix corresponding to the elements in the sample matrices. A number of inferences are performed with the trained neural network, wherein the weight matrix of the trained neural network is replaced with the sample matrices, and wherein each inference is performed with a different one of the sample matrices. A confidence level of the inferences is determined according to deviations between the first choice and other choices made by the trained neural network across the inferences.

Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

Abstract: Methods of increasing formability of a palm sheath material, methods of producing a palm sheath-based product, and palm sheath foodware produced thereby. The formability of a palm sheath material is increased by treating the palm sheath material with a fluid substance that weakens bonds between cellulose fibers of the palm sheath material by partially eliminating lignin and hemicellulose of the palm sheath material. The treated palm sheath material can be used to form various products, such as foodware products by deforming the treated palm sheath material into a shape. Advantageously, the treated palm sheath material can typically be deformed by stretching or punching using dies to a height to diameter aspect ratio of greater than 0.2 and/or to a limit strain of the palm sheath material greater than 0.38.

Abstract: Encoding terrain maps is provided. The method comprises receiving a digital elevation model (DEM) of a terrain and encoding the DEM into grid cells parameterized by spatial scale, orientation, and 2D offset. Grid cells with shared scale and orientation are aggregated into grid modules. Locations from the DEM that correspond to a given elevation produce a contour line of locations that fall within the given elevation. 2D phase codes are calculated for each grid module to produce a phase candidate dictionary, wherein a subset of phase codes comprises phase candidates corresponding to locations from the contour line. When sensor data is received along a trajectory over the terrain, the phase candidate dictionary is queried. Phase candidates are corrected for relative displacement from a reference point and summed to produce a coincidence map over the DEM that identifies a current location estimate over the terrain.

Abstract: Systems and methods are provided for monitoring a plurality of chat messages. Values are extracted from multiple chat messages between a first party and a second party. Context is determined for the values and/or messages. The context is used to determine the relationship between the values, messages, and one or more transactions. Once all values of a transaction are identified, an order ticket is generated.

Abstract: A device for machining material includes a rotatable turret including a plurality of plank holding positions, each plank holding position including a plank holding device. A projector is configured to project at least one cut line on a first surface of a plank. A cutting device is positioned adjacent to the turret, the cutting device includes a cutting tool configured to cut a trim section along a second surface of the plank to establish a substantially planar portion and/or to locate defects of the first edge. A sensor is configured to scan the first edge of the plank and determine whether the groove and the substantially planar portion are within a predetermined tolerance. A jointing device is positioned adjacent to the turret, the jointing device includes a joint cutting tool configured to cut at least one groove on the second surface.

Abstract: The present invention concerns an Axl inhibitor and one or more immune checkpoint (activity) modulators and/or one or more oncolytic viruses, for use in the prevention, treatment or management of cancer, wherein the Axl inhibitor and the one or more immune checkpoint (activity) modulators and/or the one or more oncolytic viruses are administered concurrently, separately or sequentially; compositions containing such components in combination; and methods of treating cancer in a patient by administering such components in combination.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the Axl protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: A component for a vehicle interior may comprise a light guide to allow light transmission from a light source, and a cover to cover the light guide. The light guide may comprise an icon or indicator and the cover may comprise a depression or indentation in an inner surface of the cover. The icon/indicator of the light guide may comprise a light-transmissive resin material configured to fit within the depression/indentation in the cover. The icon/indicator may be presented when illuminated and hidden by the cover when not illuminated. The cover may comprise a polymer material coupled to the light guide. The cover may present a user interface. A surface of the cover may comprise an information region and/or a decorative region. The component may comprise a steering wheel, console, floor console, center console, instrument panel, door panel, dashboard, display, armrest, or cockpit.