Patents by Inventor James A. Bristol

James A. Bristol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3,4-Triazolo[1,5-a]pyridines
    Patent number: 4358454
    Abstract: There are disclosed herein certain 1,3,4-triazolo[1,5-a]pyridine compounds which are useful in the treatment of peptic ulcer diseases.
    Type: Grant
    Filed: January 8, 1982
    Date of Patent: November 9, 1982
    Assignee: Schering Corporation
    Inventors: James A. Bristol, Raymond G. Lovey
  • 1,2,4-Triazolo[4,3-a]pyridines
    Patent number: 4358453
    Abstract: There are disclosed herein certain 1,2,4-triazolo-[4,3-a]pyridine compounds which are useful in the treatment of peptic ulcer diseases.
    Type: Grant
    Filed: January 8, 1982
    Date of Patent: November 9, 1982
    Assignee: Schering Corporation
    Inventors: James A. Bristol, Raymond G. Lovey
  • Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
    Patent number: 4353905
    Abstract: Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)-phenyl]-3(2H)-pyridazinone compounds and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic agents.Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted .gamma.-oxo-benzenebutanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones which are dehydrogenated to 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones.Both the intermediate 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and the 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones are useful as cardiotonic agents.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: October 12, 1982
    Assignee: Warner-Lambert Company
    Inventors: Ila Sircar, James A. Bristol
  • Diels-alder adducts of benzoxadiazepines and benzothiadiazepines
    Patent number: 4062852
    Abstract: Compounds having the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein Z is oxygen, sulfur or methylene; R.sub.1 is hydrogen, halogen, alkyl, aryl or arylalkyl; R.sub.2 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is hydrogen, alkyl, aryl or arylalkyl; and R.sub.4 is hydrogen, halogen, alkyl, phenyl, dialkylamidosulfonyl or trifluoromethyl, have useful central nervous system activity.
    Type: Grant
    Filed: October 22, 1976
    Date of Patent: December 13, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol
  • Hydrogenated diels-alder adducts of benzdiazepines
    Patent number: 4022790
    Abstract: Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof; wherein Z is oxygen, sulfur or methylene; R.sub.1 is hydrogen, halogen, alkyl, aryl or arylalkyl; R.sub.2 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is hydrogen, alkyl, aryl or arylalkyl; and R.sub.4 is hydrogen, halogen, alkyl, phenyl, dialkylamidosulfonyl or trifluoromethyl; have useful central nervous system activity.
    Type: Grant
    Filed: July 20, 1976
    Date of Patent: May 10, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol
  • Amino-benzimidazole derivatives
    Patent number: 4004016
    Abstract: Amino-benzimidazole derivatives of the structure ##STR1## are provided which are useful as anti-inflammatory agents. In addition, a method for preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such pharmaceutical compositions in the treatment of inflammation are taught.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: January 18, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol
  • Diels-alder adducts of benzdiazepines
    Patent number: 4003905
    Abstract: Compounds having the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein Z is oxygen, sulfur or methylene; R.sub.1 is hydrogen, halogen, alkyl, aryl or arylalkyl; R.sub.2 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is hydrogen, alkyl, aryl or arylalkyl; and R.sub.4 is hydrogen, halogen, alkyl, phenyl, dialkylamidosulfonyl or trifluoromethyl, have useful central nervous system activity.
    Type: Grant
    Filed: December 11, 1974
    Date of Patent: January 18, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol
  • Hydrogenated diels-alder adducts of benzdiazepines
    Patent number: 3984418
    Abstract: Compounds having the structure ##SPC1##And the pharmaceutically acceptable salts thereof; wherein Z is oxygen, sulfur or methylene; R.sub.1 is hydrogen, halogen, alkyl, aryl or arylalkyl; R.sub.2 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is hydrogen, alkyl, aryl or arylalkyl; and R.sub.4 is hydrogen, halogen, alkyl, phenyl, dialkylamidosulfonyl or trifluoromethyl; have useful central nervous system activity.
    Type: Grant
    Filed: April 15, 1975
    Date of Patent: October 5, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol
  • Derivatives of [[(1-piperidinyl)ethyl]phenyl]alkanediamines
    Patent number: 3984421
    Abstract: Compounds of the formula ##SPC1##And pharmaceutically acceptable salts alkylthio, wherein R.sub.1 is hydrogen, halogen, alkyl, alkoxy, alkythio, benzyl, phenylethyl, phenyl, phenylthio, or phenyl mono-substituted with a halogen, an alkyl group, an alkoxy group or a trifluoromethyl group; R.sub.2 is hydrogen, Halogen, alkyl, alkoxy, alkylthio, alkylsulfonyl, phenyl phenyloxy, sulfamoyl, dialkylamidosulfonyl, trifluoromethyl or phenyl or phenyloxy mono-substituted with a halogen, an alkyl group, an alkoxy group or a trifluoromethyl group; R.sub.3 is hydrogen, alkyl or or hydroxyalkyl; and n is 2, 3 or 4 are useful as central nervous system depressants.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: October 5, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol
  • Amino-benzimidazole derivatives
    Patent number: 3981886
    Abstract: Amino-benzimidazole derivatives of the structure ##SPC1##Are provided which are useful as anti-inflammatory agents. In addition, a method for preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such pharmaceutical compositions in the treatment of inflammation are taught.
    Type: Grant
    Filed: January 20, 1975
    Date of Patent: September 21, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harry L. Yale, James A. Bristol